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1RQY
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BU of 1rqy by Molmil
9-amino-[N-(2-dimethylamino)proply]-acridine-4-carboxamide bound to d(CGTACG)2
Descriptor: 5'-D(CP*GP*TP*AP*CP*G)-3', 9-AMINO-N-[3-(DIMETHYLAMINO)PROPYL]ACRIDINE-4-CARBOXAMIDE, COBALT (II) ION, ...
Authors:Adams, A, Guss, J.M, Denny, W.A, Wakelin, L.P.
Deposit date:2003-12-07
Release date:2004-05-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of 9-amino-[N-(2-dimethylamino)propyl]acridine-4-carboxamide bound to d(CGTACG)(2): a comparison of structures of d(CGTACG)(2) complexed with intercalatorsin the presence of cobalt.
Acta Crystallogr.,Sect.D, 60, 2004
465D
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BU of 465d by Molmil
STRUCTURE OF THE TOPOISOMERASE II POISON BOUND TO DNA
Descriptor: 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3')
Authors:Adams, A, Guss, J.M, Collyer, C.A, Denny, W.A, Wakelin, L.P.
Deposit date:1999-04-14
Release date:1999-08-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.
Biochemistry, 38, 1999
1DL8
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BU of 1dl8 by Molmil
CRYSTAL STRUCTURE OF 5-F-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CGTACG)2
Descriptor: 5-FLUORO-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3')
Authors:Adams, A, Guss, J.M, Collyer, C.A, Denny, W.A, Wakelin, L.P.
Deposit date:1999-12-08
Release date:2000-10-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides.
Mol.Pharmacol., 58, 2000
243D
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BU of 243d by Molmil
STRUCTURE OF THE DNA OCTANUCLEOTIDE D(ACGTACGT)2
Descriptor: DNA (5'-D(*AP*CP*GP*TP*AP*CP*GP*T)-3')
Authors:Wilcock, D.J, Adams, A, Cardin, C.J, Wakelin, L.P.G.
Deposit date:1996-01-10
Release date:1996-02-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the DNA octanucleotide d(ACGTACGT)2.
Acta Crystallogr.,Sect.D, 52, 1996
1KCI
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BU of 1kci by Molmil
Crystal Structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide Bound to d(CGTACG)2
Descriptor: 5'-D(*CP*GP*TP*AP*CP*G)-3', 9-AMINO-N-[2-(4-MORPHOLINYL)ETHYL]-4-ACRIDINECARBOXAMIDE
Authors:Adams, A, Guss, J.M, Denny, W.A, Wakelin, L.P.G.
Deposit date:2001-11-08
Release date:2002-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons.
Nucleic Acids Res., 30, 2002
1FN1
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CRYSTAL STRUCTURE OF 9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CG(5BR)UACG)2
Descriptor: 9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE, COBALT (II) ION, DNA (5'-D(*CP*GP*(BRO)UP*AP*CP*G)-3'), ...
Authors:Adams, A, Guss, J.M, Collyer, C.A, Denny, W.A, Wakelin, L.P.G.
Deposit date:2000-08-19
Release date:2000-10-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A novel form of intercalation involving four DNA duplexes in an acridine-4-carboxamide complex of d(CGTACG)(2).
Nucleic Acids Res., 28, 2000
1FN2
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BU of 1fn2 by Molmil
9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CGTACG)2
Descriptor: 9-AMINO-(N-(2-DIMETHYLAMINO)BUTYL)ACRIDINE-4-CARBOXAMIDE, COBALT (II) ION, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), ...
Authors:Adams, A, Guss, J.M, Collyer, C.A, Denny, W.A, Wakelin, L.P.G.
Deposit date:2000-08-19
Release date:2000-10-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A novel form of intercalation involving four DNA duplexes in an acridine-4-carboxamide complex of d(CGTACG)(2).
Nucleic Acids Res., 28, 2000
344D
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BU of 344d by Molmil
DETERMINATION BY MAD-DM OF THE STRUCTURE OF THE DNA DUPLEX D(ACGTACG(5-BRU))2 AT 1.46A AND 100K
Descriptor: DNA (5'-D(*AP*CP*GP*TP*AP*CP*GP*(BRU))-3')
Authors:Todd, A.R, Adams, A, Powell, H.R, Cardin, C.J.
Deposit date:1997-08-04
Release date:1997-09-26
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Determination by MAD-DM of the structure of the DNA duplex d[ACGTACG(5-BrU)]2 at 1.46 A and 100 K.
Acta Crystallogr.,Sect.D, 55, 1999
366D
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BU of 366d by Molmil
1.3 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/6-BROMO-9-AMINO-DACA COMPLEX
Descriptor: 6-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE, DNA (5'-D(*CP*GP*(BRU)P*AP*CP*G)-3')
Authors:Todd, A.K, Adams, A, Thorpe, J.H, Denny, W.A, Cardin, C.J.
Deposit date:1997-12-19
Release date:1999-04-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.
J.Med.Chem., 42, 1999

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PDB entries from 2024-03-27

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