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5TBW
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CRYSTAL STRUCTURE OF CHLOROLISSOCLIMIDE BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Konst, Z.A., Szklarski, A.R., Pellegrino, S., Michalak, S.E., Meyer, M., Zanette, C., Cencic, R., Nam, S., Horne, D.A., Pelletier, J., Mobley, D.L., Yusupova, G., Yusupov, M., Vanderwal, C.D.
Deposit date:2016-09-13
Release date:2017-07-26
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
5WGC
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PROPIONYL-DPSC IN COMPLEX WITH OXETANE-BEARING PROBE
Descriptor:Daunorubicin-doxorubicin polyketide synthase, (3-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}oxetan-3-yl)acetic acid
Authors:Milligan, J.C., Ellis, B.D., White, A.R., Vanderwal, C.D., Tsai, S.C.
Deposit date:2017-07-13
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.
J. Am. Chem. Soc., 140, 2018
6HHQ
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CRYSTAL STRUCTURE OF COMPOUND C45 BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Vanderwal, C.D., Yusupov, M.
Deposit date:2018-08-28
Release date:2019-02-20
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
Nucleic Acids Res., 47, 2019
6QTN
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TUBULIN-CYCLOSTREPTIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Balaguer, F.d.A., Muehlethaler, T., Estevez-Gallego, J., Calvo, E., Gimenez-Abian, J.F., Risinger, A.L., Sorensen, E.J., Vanderwal, C.D., Altmann, K.-H., Mooberry, S.L., Steinmetz, M.O., Oliva, M.A., Prota, A.E., Diaz, J.F.
Deposit date:2019-02-25
Release date:2019-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.
Int J Mol Sci, 20, 2019