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4X4J
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BU of 4x4j by Molmil
Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Putative oxygenase, SULFATE ION
Authors:Tsai, S.-C, Jackson, D.R, Patel, A, Barajas, J.F, Rohr, J, Yu, X, Liu, H.-W, Sasaki, E, Calveras, J, Metsa-Ketela, M.
Deposit date:2014-12-02
Release date:2015-12-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
To Be Published
1MNA
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BU of 1mna by Molmil
Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0
Descriptor: polyketide synthase IV
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNQ
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BU of 1mnq by Molmil
Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4
Descriptor: polyketide synthase IV
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MO2
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BU of 1mo2 by Molmil
Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE), pH 8.5
Descriptor: Erythronolide synthase, modules 5 and 6
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MN6
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BU of 1mn6 by Molmil
Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6
Descriptor: polyketide synthase IV
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
3BB8
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BU of 3bb8 by Molmil
E1 Dehydrase H220K Mutant
Descriptor: BENZAMIDINE, CDP-4-keto-6-deoxy-D-glucose-3-dehydrase, PYRIDOXAL-5'-PHOSPHATE
Authors:Tsai, S.-C, Smith, P.
Deposit date:2007-11-09
Release date:2008-09-16
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:E1 Dehydrase H220K Mutant
To be Published
3BCX
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BU of 3bcx by Molmil
E1 Dehydrase
Descriptor: BENZAMIDINE, CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase, FE (III) ION
Authors:Tsai, S.-C, Smith, P.
Deposit date:2007-11-13
Release date:2007-11-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:E1 Dehydrase.
To be Published
1R2J
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BU of 1r2j by Molmil
FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, protein FkbI
Authors:Watanabe, K, Khosla, C, Stroud, R.M, Tsai, S.-C.
Deposit date:2003-09-28
Release date:2003-11-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis
J.Mol.Biol., 334, 2003
3GQV
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BU of 3gqv by Molmil
Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP
Descriptor: Enoyl reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Ames, B.D, Smith, P.T, Ma, S.M, Kaake, R, Wong, E.W, Wong, S.K, Xie, X, Li, J.W, Vederas, J.C, Tang, Y, Tsai, S.-C.
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:biosynthesis of Lovastatin: Crystal structure and biochemical studies of LOVC, A trans-acting polyketide enoyl reductase
To be Published
2RH4
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BU of 2rh4 by Molmil
Actinorhodin ketoreductase, actKR, with NADPH and Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Korman, T.P, Tsai, S.-C.
Deposit date:2007-10-05
Release date:2008-08-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
2RHC
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BU of 2rhc by Molmil
Actinorhodin ketordeuctase, actKR, with NADP+ and Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Korman, T.P, Tsai, S.-C.
Deposit date:2007-10-08
Release date:2008-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
2RHR
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BU of 2rhr by Molmil
P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Korman, T.P, Tsai, S.-C.
Deposit date:2007-10-09
Release date:2008-08-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
1XNY
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BU of 1xny by Molmil
Biotin and propionyl-CoA bound to Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB)
Descriptor: BIOTIN, propionyl Coenzyme A, propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XNW
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BU of 1xnw by Molmil
Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #2, mutant D422I
Descriptor: propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XNV
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BU of 1xnv by Molmil
Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #1
Descriptor: propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XO6
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BU of 1xo6 by Molmil
Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #3
Descriptor: propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1KEZ
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BU of 1kez by Molmil
Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE)
Descriptor: ERYTHRONOLIDE SYNTHASE
Authors:Tsai, S.-C, Miercke, L.J.W, Krucinski, J, Gokhale, R, Chen, J.C.-H, Foster, P.G, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2001-11-19
Release date:2002-01-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proc.Natl.Acad.Sci.USA, 98, 2001
4DC0
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BU of 4dc0 by Molmil
Crystal Structure of F189W Actinorhodin Polyketide Ketoreductase with NADPH
Descriptor: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Javidpour, P, Tsai, S.-C.
Deposit date:2012-01-16
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
Chem.Biol., 20, 2013
4DBZ
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BU of 4dbz by Molmil
Crystal Structure of V151L Actinorhodin Polyketide Ketoreductase with NADPH
Descriptor: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Javidpour, P, Tsai, S.-C.
Deposit date:2012-01-16
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.643 Å)
Cite:The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
Chem.Biol., 20, 2013
4DC1
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BU of 4dc1 by Molmil
Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH
Descriptor: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Javidpour, P, Tsai, S.-C.
Deposit date:2012-01-16
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
Chem.Biol., 20, 2013
3B6Z
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BU of 3b6z by Molmil
Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA
Descriptor: Enoyl reductase, GLYCEROL, S-{(9R,13R,15S)-17-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl}(2E)-but-2-enethioate
Authors:Ames, B.D, Smith, P.T, Ma, S.M, Wong, E.W, Xie, X, Vederas, J.C, Tang, Y, Tsai, S.-C.
Deposit date:2007-10-29
Release date:2008-09-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
3B70
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BU of 3b70 by Molmil
Crystal structure of Aspergillus terreus trans-acting lovastatin polyketide enoyl reductase (LovC) with bound NADP
Descriptor: Enoyl reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Ames, B.D, Smith, P.T, Ma, S.M, Wong, E.W, Xie, X, Vederas, J.C, Tang, Y, Tsai, S.-C.
Deposit date:2007-10-29
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
3HF1
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BU of 3hf1 by Molmil
Crystal structure of human p53R2
Descriptor: FE (III) ION, Ribonucleoside-diphosphate reductase subunit M2 B, SULFATE ION
Authors:Smith, P, Zhou, B, Yuan, Y.-C, Su, L, Tsai, S.-C, Yen, Y.
Deposit date:2009-05-10
Release date:2009-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase .
Biochemistry, 48, 2009
3QRW
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BU of 3qrw by Molmil
Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH
Descriptor: FORMIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ketoacyl reductase
Authors:Korman, T.P, Javidpour, P, Tsai, S.-C.
Deposit date:2011-02-18
Release date:2011-05-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase.
Biochemistry, 50, 2011
3RI3
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BU of 3ri3 by Molmil
Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ketoacyl reductase
Authors:Javidpour, P, Tsai, S.-C.
Deposit date:2011-04-12
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase.
Biochemistry, 50, 2011

 

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