Author results

4XQ8
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HUMAN DNA POLYMERASE LAMBDA- MGDATP BINARY COMPLEX AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Tsai, M.D., Liu, M.S.
Deposit date:2015-01-19
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
2B96
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THIRD CALCIUM ION FOUND IN AN INHIBITOR BOUND PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, CHLORIDE ION, ...
Authors:Sekar, K., Velmurugan, D., Yamane, T., Tsai, M.D.
Deposit date:2005-10-11
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Third Calcium ion found in an inhibitor bound phospholipase A2
Acta Crystallogr.,Sect.D, 62, 2006
2BAX
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ATOMIC RESOLUTION STRUCTURE OF THE DOUBLE MUTANT (K53,56M) OF BOVINE PANCREATIC PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, CHLORIDE ION, ...
Authors:Sekar, K., Yogavel, M., Velmurugan, D., Dauter, Z., Dauter, M., Tsai, M.D.
Deposit date:2005-10-15
Release date:2005-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2.
Acta Crystallogr.,Sect.F, 61, 2005
4XRH
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HUMAN DNA POLYMERASE LAMBDA- MGDTTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-01-21
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CA7
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HUMAN DNA POLYMERASE LAMBDA- MGDGTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-06-29
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.522 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CB1
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APO ENZYME OF HUMAN POLYMERASE LAMBDA
Descriptor:DNA polymerase lambda
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-06-30
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CHG
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- MGDGTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-10
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CJ7
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- MGDTTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-14
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CP2
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- APOENZYME AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-21
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CR0
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- MGDCTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-22
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CWR
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA L431A MUTANT IN COMPLEX WITH A ONE NUCLEOTIDE DNA GAP AND DCTP
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-28
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5DDM
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HUMAN DNA POLYMERASE LAMBDA- APOENZYME AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-08-25
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5DDY
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BINARY COMPLEX OF HUMAN POLYMERASE LAMBDA WITH DCTP
Descriptor:DNA polymerase lambda, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-08-25
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3.36 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5DKW
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TERNARY CRYSTAL STRUCTURE OF POLYMERASE LAMBDA WITH A GA MISPAIR AT THE PRIMER TERMINUS WITH CA2+ IN THE ACTIVE
Descriptor:DNA polymerase lambda, DNA (5'-D(P*GP*CP*CP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-09-04
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.689 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5XZW
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CRYSTAL STRUCTURE OF RAD53 1-466
Descriptor:Serine/threonine-protein kinase RAD53
Authors:Weng, J.H., Tsai, M.D.
Deposit date:2017-07-14
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation
Biochemistry, 56, 2017
2AFF
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THE SOLUTION STRUCTURE OF THE KI67FHA/HNIFK(226-269)3P COMPLEX
Descriptor:Antigen KI-67, MKI67 FHA domain interacting nucleolar phosphoprotein
Authors:Byeon, I.-J.L., Li, H., Song, H., Gronenborn, A.M., Tsai, M.D.
Deposit date:2005-07-25
Release date:2005-10-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.
Nat.Struct.Mol.Biol., 12, 2005
1C74
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STRUCTURE OF THE DOUBLE MUTANT (K53,56M) OF PHOSPHOLIPASE A2
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Sekar, K., Tsai, M.D., Jain, M.K., Ramakumar, S.
Deposit date:2000-01-22
Release date:2000-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of the anionic interface preference and k*cat activation of pancreatic phospholipase A2.
Biochemistry, 39, 2000
1D9S
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TUMOR SUPPRESSOR P15(INK4B) STRUCTURE BY COMPARATIVE MODELING AND NMR DATA
Descriptor:CYCLIN-DEPENDENT KINASE 4 INHIBITOR B
Authors:Yuan, C., Ji, L., Selby, T.L., Byeon, I.J.L., Tsai, M.D.
Deposit date:1999-10-29
Release date:2000-07-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).
J.Mol.Biol., 294, 1999
1GH4
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STRUCTURE OF THE TRIPLE MUTANT (K56M, K120M, K121M) OF PHOSPHOLIPASE A2
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Sekar, K., Velmurugan, D., Tsai, M.D.
Deposit date:2000-11-09
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2.
J.Mol.Biol., 324, 2002
1O2E
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STRUCTURE OF THE TRIPLE MUTANT (K53,56,120M) + ANISIC ACID COMPLEX OF PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, 4-METHOXYBENZOIC ACID
Authors:Sekar, K., Velmurugan, D., Tsai, M.D.
Deposit date:2003-03-05
Release date:2003-09-09
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2.
J.Mol.Biol., 333, 2003
1R21
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SOLUTION STRUCTURE OF HUMAN KI67 FHA DOMAIN
Descriptor:Antigen Ki-67
Authors:Byeon, I.J., Li, H., Tsai, M.D.
Deposit date:2003-09-25
Release date:2003-12-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of Human Ki67 FHA Domain and its Binding to a Phosphoprotein Fragment from hNIFK Reveal Unique Recognition Sites and New Views to the Structural Basis of FHA Domain Functions
J.Mol.Biol., 335, 2004
1TR4
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SOLUTION STRUCTURE OF HUMAN ONCOGENIC PROTEIN GANKYRIN
Descriptor:26S proteasome non-ATPase regulatory subunit 10
Authors:Yuan, C., Li, J., Mahajan, A., Poi, M.J., Byeon, I.J., Tsai, M.D.
Deposit date:2004-06-19
Release date:2004-11-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship.
Biochemistry, 43, 2004
2BCH
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A POSSIBLE OF SECOND CALCIUM ION IN INTERFACIAL BINDING: ATOMIC AND MEDIUM RESOLUTION CRYSTAL STRUCTURES OF THE QUADRUPLE MUTANT OF PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, CHLORIDE ION, ...
Authors:Sekar, K., Yogavel, M., Velmurugan, D., Poi, M.J., Dauter, Z., Tsai, M.D.
Deposit date:2005-10-19
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Suggestive evidence for the involvement of the second calcium and surface loop in interfacial binding: monoclinic and trigonal crystal structures of a quadruple mutant of phospholipase A(2).
Acta Crystallogr.,Sect.D, 62, 2006
2BD1
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A POSSIBLE ROLE OF THE SECOND CALCIUM ION IN INTERFACIAL BINDING: ATOMIC AND MEDIUM RESOLUTION CRYSTAL STRUCTURES OF THE QUADRUPLE MUTANT OF PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Sekar, K., Velmurugan, D., Tsai, M.D.
Deposit date:2005-10-19
Release date:2006-07-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Suggestive evidence for the involvement of the second calcium and surface loop in interfacial binding: monoclinic and trigonal crystal structures of a quadruple mutant of phospholipase A(2).
Acta Crystallogr.,Sect.D, 62, 2006
2X9L
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CRYSTAL STRUCTURE OF DEACETYLASE-BOG COMPLEX IN BIOSYNTHESIS PATHWAY OF TEICOPLANIN.
Descriptor:N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE, ZINC ION, B-OCTYLGLUCOSIDE
Authors:Chan, H.C., Huang, Y.T., Lyu, S.Y., Huang, C.J., Li, Y.S., Liu, Y.C., Chou, C.C., Tsai, M.D., Li, T.L.
Deposit date:2010-03-23
Release date:2011-02-09
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (1.732 Å)
Cite:Regioselective Deacetylation Based on Teicoplanin-Complexed Orf2 Crystal Structures.
Mol.Biosyst., 7, 2011