Author results

4XQ8
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HUMAN DNA POLYMERASE LAMBDA- MGDATP BINARY COMPLEX AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Tsai, M.D., Liu, M.S.
Deposit date:2015-01-19
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
2B96
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THIRD CALCIUM ION FOUND IN AN INHIBITOR BOUND PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, CHLORIDE ION, ...
Authors:Sekar, K., Velmurugan, D., Yamane, T., Tsai, M.D.
Deposit date:2005-10-11
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Third Calcium ion found in an inhibitor bound phospholipase A2
Acta Crystallogr.,Sect.D, 62, 2006
2BAX
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ATOMIC RESOLUTION STRUCTURE OF THE DOUBLE MUTANT (K53,56M) OF BOVINE PANCREATIC PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, CHLORIDE ION, ...
Authors:Sekar, K., Yogavel, M., Velmurugan, D., Dauter, Z., Dauter, M., Tsai, M.D.
Deposit date:2005-10-15
Release date:2005-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2.
Acta Crystallogr.,Sect.F, 61, 2005
4XRH
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HUMAN DNA POLYMERASE LAMBDA- MGDTTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-01-21
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CA7
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HUMAN DNA POLYMERASE LAMBDA- MGDGTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-06-29
Release date:2016-02-24
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (2.522 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CB1
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APO ENZYME OF HUMAN POLYMERASE LAMBDA
Descriptor:DNA polymerase lambda
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-06-30
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CHG
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- MGDGTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-10
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CJ7
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- MGDTTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-14
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CP2
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- APOENZYME AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-21
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CR0
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HUMAN DNA POLYMERASE LAMBDA L431A MUTANT- MGDCTP BINARY AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-22
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5CWR
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA L431A MUTANT IN COMPLEX WITH A ONE NUCLEOTIDE DNA GAP AND DCTP
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-07-28
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5DDM
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HUMAN DNA POLYMERASE LAMBDA- APOENZYME AND COMPLEX WITH 6 PAIRED DNA
Descriptor:DNA polymerase lambda, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*CP*TP*G)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-08-25
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5DDY
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BINARY COMPLEX OF HUMAN POLYMERASE LAMBDA WITH DCTP
Descriptor:DNA polymerase lambda, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-08-25
Release date:2016-02-24
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (3.36 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5DKW
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TERNARY CRYSTAL STRUCTURE OF POLYMERASE LAMBDA WITH A GA MISPAIR AT THE PRIMER TERMINUS WITH CA2+ IN THE ACTIVE
Descriptor:DNA polymerase lambda, DNA (5'-D(P*GP*CP*CP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ...
Authors:Liu, M.S., Tsai, M.D.
Deposit date:2015-09-04
Release date:2016-02-24
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (2.689 Å)
Cite:Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
J.Am.Chem.Soc., 138, 2016
5XZW
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CRYSTAL STRUCTURE OF RAD53 1-466
Descriptor:Serine/threonine-protein kinase RAD53
Authors:Weng, J.H., Tsai, M.D.
Deposit date:2017-07-14
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation
Biochemistry, 56, 2017
6IS7
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STRUCTURE OF 9N-I DNA POLYMERASE INCORPORATION WITH DA IN THE ACTIVE SITE
Descriptor:DNA polymerase, DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*A)-3'), DNA (5'-D(*AP*CP*TP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ...
Authors:Linwu, S.W., Maestre-Reyna, M., Tsai, M.D., Tu, Y.H., Chang, W.H.
Deposit date:2018-11-15
Release date:2019-08-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6ISF
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STRUCTURE OF 9N-I DNA POLYMERASE INCORPORATION WITH DT IN THE ACTIVE SITE
Descriptor:DNA polymerase, DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ...
Authors:Linwu, S.W., Maestre-Reyna, M., Tsai, M.D., Tu, Y.H., Chang, W.H.
Deposit date:2018-11-16
Release date:2019-08-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6ISG
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STRUCTURE OF 9N-I DNA POLYMERASE INCORPORATION WITH DG IN THE ACTIVE SITE
Descriptor:DNA polymerase, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*G)-3'), DNA (5'-D(*GP*AP*CP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*G)-3'), ...
Authors:Linwu, S.W., Maestre-Reyna, M., Tsai, M.D., Tu, Y.H., Chang, W.H.
Deposit date:2018-11-16
Release date:2019-08-28
Method:X-RAY DIFFRACTION (3.401 Å)
Cite:Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6ISH
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STRUCTURE OF 9N-I DNA POLYMERASE INCORPORATION WITH 3'-AL IN THE ACTIVE SITE
Descriptor:DNA polymerase, DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*(DAL))-3'), DNA (5'-D(*AP*CP*TP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*C)-3'), ...
Authors:Linwu, S.W., Maestre-Reyna, M., Tsai, M.D., Tu, Y.H., Chang, W.H.
Deposit date:2018-11-16
Release date:2019-08-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6ISI
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STRUCTURE OF 9N-I DNA POLYMERASE INCORPORATION WITH 3'-CL IN THE ACTIVE SITE
Descriptor:DNA polymerase, DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*C)-3'), DNA (5'-D(P*AP*CP*GP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ...
Authors:Linwu, S.W., Maestre-Reyna, M., Tsai, M.D., Tu, Y.H., Chang, W.H.
Deposit date:2018-11-16
Release date:2019-08-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
2AFF
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THE SOLUTION STRUCTURE OF THE KI67FHA/HNIFK(226-269)3P COMPLEX
Descriptor:Antigen KI-67, MKI67 FHA domain interacting nucleolar phosphoprotein
Authors:Byeon, I.-J.L., Li, H., Song, H., Gronenborn, A.M., Tsai, M.D.
Deposit date:2005-07-25
Release date:2005-10-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.
Nat.Struct.Mol.Biol., 12, 2005
1C74
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STRUCTURE OF THE DOUBLE MUTANT (K53,56M) OF PHOSPHOLIPASE A2
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Sekar, K., Tsai, M.D., Jain, M.K., Ramakumar, S.
Deposit date:2000-01-22
Release date:2000-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of the anionic interface preference and k*cat activation of pancreatic phospholipase A2.
Biochemistry, 39, 2000
1D9S
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TUMOR SUPPRESSOR P15(INK4B) STRUCTURE BY COMPARATIVE MODELING AND NMR DATA
Descriptor:CYCLIN-DEPENDENT KINASE 4 INHIBITOR B
Authors:Yuan, C., Ji, L., Selby, T.L., Byeon, I.J.L., Tsai, M.D.
Deposit date:1999-10-29
Release date:2000-07-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).
J.Mol.Biol., 294, 1999
1GH4
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STRUCTURE OF THE TRIPLE MUTANT (K56M, K120M, K121M) OF PHOSPHOLIPASE A2
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Sekar, K., Velmurugan, D., Tsai, M.D.
Deposit date:2000-11-09
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2.
J.Mol.Biol., 324, 2002
1O2E
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STRUCTURE OF THE TRIPLE MUTANT (K53,56,120M) + ANISIC ACID COMPLEX OF PHOSPHOLIPASE A2
Descriptor:Phospholipase A2, CALCIUM ION, 4-METHOXYBENZOIC ACID
Authors:Sekar, K., Velmurugan, D., Tsai, M.D.
Deposit date:2003-03-05
Release date:2003-09-09
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2.
J.Mol.Biol., 333, 2003