Author results

1MSV
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THE S68A S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME PROCESSING MUTANT.
Descriptor:S-adenosylmethionine decarboxylase proenzyme, 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Tolbert, W.D., Zhang, Y., Bennett, E.M., Cottet, S.E., Ekstrom, J.L., Pegg, A.E., Ealick, S.E.
Deposit date:2002-09-19
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanism of Human S-Adenosylmethionine Decarboxylase Proenzyme Processing as Revealed by the Structure of the S68A Mutant.
Biochemistry, 42, 2003
1I72
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HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE
Descriptor:S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE, ...
Authors:Tolbert, W.D., Ekstrom, J.L., Mathews, I.I., Secrist III, J.A., Pegg, A.E., Ealick, S.E.
Deposit date:2001-03-07
Release date:2001-08-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry, 40, 2001
1I79
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HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND 5'-DEOXY-5'-[(3-HYDRAZINOPROPYL)METHYLAMINO]ADENOSINE
Descriptor:S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, 5'-DEOXY-5'-[(3-HYDRAZINOPROPYL)METHYLAMINO]ADENOSINE, ...
Authors:Tolbert, W.D., Ekstrom, J.L., Mathews, I.I., Secrist III, J.A., Pegg, A.E., Ealick, S.E.
Deposit date:2001-03-08
Release date:2001-08-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry, 40, 2001
1I7B
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HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COVALENTLY BOUND S-ADENOSYLMETHIONINE METHYL ESTER
Descriptor:S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, S-ADENOSYLMETHIONINE METHYL ESTER, ...
Authors:Tolbert, W.D., Ekstrom, J.L., Mathews, I.I., Secrist III, J.A., Pegg, A.E., Ealick, S.E.
Deposit date:2001-03-08
Release date:2001-08-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry, 40, 2001
1I7C
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HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH METHYLGLYOXAL BIS-(GUANYLHYDRAZONE)
Descriptor:S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, 1,4-DIAMINOBUTANE, ...
Authors:Tolbert, W.D., Ekstrom, J.L., Mathews, I.I., Secrist III, J.A., Pegg, A.E., Ealick, S.E.
Deposit date:2001-03-08
Release date:2001-08-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry, 40, 2001
1I7M
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HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE
Descriptor:S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, 1,4-DIAMINOBUTANE, ...
Authors:Tolbert, W.D., Ekstrom, J.L., Mathews, I.I., Secrist III, J.A., Pegg, A.E., Ealick, S.E.
Deposit date:2001-03-09
Release date:2001-08-22
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry, 40, 2001
1MT1
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THE CRYSTAL STRUCTURE OF PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE FROM METHANOCOCCUS JANNASCHII
Descriptor:PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN, PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN, AGMATINE
Authors:Tolbert, W.D., Graham, D.E., White, R.H., Ealick, S.E.
Deposit date:2002-09-20
Release date:2003-03-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii: Crystal Structures of the Self-Cleaved and S53A Proenzyme Forms
Structure, 11, 2003
1N13
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THE CRYSTAL STRUCTURE OF PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE FROM METHANOCOCCUS JANNASHII
Descriptor:Pyruvoyl-dependent arginine decarboxylase beta chain, Pyruvoyl-dependent arginine decarboxylase alpha chain, AGMATINE, ...
Authors:Tolbert, W.D., Graham, D.E., White, R.H., Ealick, S.E.
Deposit date:2002-10-16
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii: Crystal Structures of the Self-Cleaved and S53A Proenzyme Forms
Structure, 11, 2003
1N2M
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THE S53A PROENZYME STRUCTURE OF METHANOCOCCUS JANNASCHII.
Descriptor:Pyruvoyl-dependent arginine decarboxylase, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Tolbert, W.D., Graham, D.E., White, R.H., Ealick, S.E.
Deposit date:2002-10-23
Release date:2003-03-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii: Crystal Structures of the Self-Cleaved and S53A Proenzyme Forms
Structure, 11, 2003
2QJ2
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A MECHANISTIC BASIS FOR CONVERTING A RECEPTOR TYROSINE KINASE AGONIST TO AN ANTAGONIST
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D., Daugherty, J., Gao, C.-F., Xe, Q., Miranti, C., Gherardi, E., Vande Woude, G., Xu, H.E.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QJ4
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A MECHANISTIC BASIS FOR CONVERTING A RECEPTOR TYROSINE KINASE AGONIST TO AN ANTAGONIST
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D., Daugherty, J., Gao, C.-F., Xe, Q., Miranti, C., Gherardi, E., Vande Woude, G., Xu, H.E.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Proc.Natl.Acad.Sci.Usa, 104, 2007
3HMR
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CRYSTAL STRUCTURE OF THE N-TERMINAL FRAGMENT (31-127) OF THE MOUSE HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HMS
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CRYSTAL CRYSTAL STRUCTURE OF THE N-TERMINAL FRAGMENT (28-126) OF THE HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR, ORTHORHOMBIC CRYSTAL FORM
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HMT
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CRYSTAL STRUCTURE OF THE N-TERMINAL FRAGMENT (28-126) OF THE HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR, TRIGONAL CRYSTAL FORM
Descriptor:Hepatocyte growth factor
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HN4
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CRYSTAL STRUCTURE OF THE NK2 FRAGMENT (28-289) OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR
Descriptor:Hepatocyte growth factor, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
4FZE
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CRYSTAL STRUCTURE OF N26_I1 FAB, AN ADCC MEDIATING ANTI-HIV-1 ANTIBODY.
Descriptor:N26_i1 Fab light chain, N26_i1 Fab heavy chain
Authors:Tolbert, W.D., Wu, X., Pazgier, M.
Deposit date:2012-07-06
Release date:2013-07-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Crystal structure of N26_i1 Fab, an ADCC mediating anti-HIV-1 antibody.
To be Published
4IUA
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CRYSTAL STRUCTURE OF THE NK2 FRAGMENT (31-290) OF THE MOUSE HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR
Descriptor:Hepatocyte growth factor, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION
Authors:Tolbert, W.D., Zhou, E., Kovach, A., Melcher, K., Xu, H.E.
Deposit date:2013-01-20
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal Structure of the NK2 Fragment of the mouse Hepatocyte Growth Factor/Scatter Factor
To be Published
4YBL
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CRYSTAL STRUCTURE OF THE STABILIZED INNER DOMAIN OF CLADE A/E HIV-1 GP120 IN COMPLEX WITH THE ADCC MEDIATING ANTI-HIV-1 ANTIBODY A32
Descriptor:Stabilized inner domain of clade A/E gp120, A32 antibody Fab heavy chain, A32 antibody light chain
Authors:Tolbert, W.D., Gohain, N., Pazgier, M.
Deposit date:2015-02-18
Release date:2016-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.
Structure, 24, 2016
4YC2
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CRYSTAL STRUCTURE OF THE STABILIZED INNER DOMAIN OF CLADE A/E HIV-1 GP120 FROM E. COLI IN COMPLEX WITH THE ANTIBODY A32.
Descriptor:The stabilized inner domain of clade A/E HIV-1 gp120 from E. coli, The antibody A32 Fab heavy chain., The antibody A32 Fab light chain.
Authors:Tolbert, W.D., Gohain, N., Pazgier, M.
Deposit date:2015-02-19
Release date:2016-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.
Structure, 24, 2016
5UWE
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CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, HUMAN ANTI-HIV ANTIBODY N12-I2 Fab LIGHT CHAIN, HUMAN ANTI-HIV ANTIBODY N12-I2 Fab HEAVY CHAIN, ...
Authors:Tolbert, W.D., Gohain, N., Pazgier, M.
Deposit date:2017-02-21
Release date:2018-08-29
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Uncovering the Co-Receptor Binding Site of HIV-1 Envelope for Antibody-Dependent Cell-Mediated Cytotoxicity.
To Be Published
5W4L
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CRYSTAL STRUCTURE OF THE NON-NEUTRALIZING AND ADCC-POTENT C11-LIKE ANTIBODY N12-I3 IN COMPLEX WITH HIV-1 CLADE A/E GP120, THE CD4 MIMETIC M48U1, AND THE ANTIBODY N5-I5.
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, CD4 mimetic peptide M48U1, Antibody N5-i5 Fab heavy chain, ...
Authors:Tolbert, W.D., Gohain, N., Pazgier, M.
Deposit date:2017-06-12
Release date:2017-11-15
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.
Structure, 25, 2017
6CJC
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CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 3)
Descriptor:Uncharacterized protein DKFZp686C11235, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Tolbert, W.D., Van, V., Pazgier, M.
Deposit date:2018-02-26
Release date:2019-03-06
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.575 Å)
Cite:CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 3)
To Be Published
4H8W
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CRYSTAL STRUCTURE OF NON-NEUTRALIZING AND ADCC-POTENT ANTIBODY N5-I5 IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND SCD4.
Descriptor:HIV-1 CLADE A/E 93TH057 (H375S) GP120, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, FAB LIGHT CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ...
Authors:Tolbert, W.D., Acharya, P., Kwong, P.D., Pazgier, M.
Deposit date:2012-09-24
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection.
J.Virol., 88, 2014
4LB1
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (HNP1) Y16A/F28A MUTANT
Descriptor:Neutrophil defensin 1
Authors:Tolbert, W.D., Wu, X., Pazgier, M.
Deposit date:2013-06-20
Release date:2013-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LB7
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (HNP1) Y16A/I20A/L25A/F28A MUTANT.
Descriptor:Neutrophil defensin 1
Authors:Tolbert, W.D., Wu, X., Pazgier, M.
Deposit date:2013-06-20
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
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