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6YVK
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BU of 6yvk by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 0.71 MGy exposure
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-04-28
Release date:2021-11-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YVM
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BU of 6yvm by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.13 MGy exposure
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-04-28
Release date:2021-11-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YVL
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BU of 6yvl by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 1.42 MGy exposure
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-04-28
Release date:2021-11-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YVN
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BU of 6yvn by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.84 MGy exposure
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-04-28
Release date:2021-11-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YWT
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BU of 6ywt by Molmil
Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution
Descriptor: 6-HYDROXYURIDINE-5'-PHOSPHATE, PROLINE, Uridine 5'-monophosphate synthase
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-04-30
Release date:2022-02-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YWU
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BU of 6ywu by Molmil
Human OMPD-domain of UMPS (K314AcK) in complex with UMP at 1.1 Angstroms resolution
Descriptor: GLYCEROL, SULFATE ION, URIDINE-5'-MONOPHOSPHATE, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-04-30
Release date:2022-02-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6YVO
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BU of 6yvo by Molmil
Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 3.55 MGy exposure
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-04-28
Release date:2022-02-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZWZ
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BU of 6zwz by Molmil
Resting state structure of the OMPD-domain of human UMPS variant (K314AcK) at 1.2 Angstroms resolution
Descriptor: SULFATE ION, Uridine 5'-monophosphate synthase
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZX3
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BU of 6zx3 by Molmil
OMPD-domain of human UMPS in complex with 6-thiocarboxamido-UMP at 1.15 Angstroms resolution
Descriptor: GLYCEROL, PROLINE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Schimdt, T.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZWY
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BU of 6zwy by Molmil
OMPD-domain of human UMPS in complex with UMP at 1.0 Angstroms resolution
Descriptor: GLYCEROL, PROLINE, URIDINE-5'-MONOPHOSPHATE, ...
Authors:Tittmann, K, Rindfleisch, S.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZX1
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BU of 6zx1 by Molmil
OMPD-domain of human UMPS in complex with 6-Aza-UMP at 1.0 Angstroms resolution
Descriptor: 6-AZA URIDINE 5'-MONOPHOSPHATE, PROLINE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZX0
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BU of 6zx0 by Molmil
OMPD-domain of human UMPS in complex with the substrate OMP at 1.25 Angstroms resolution
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6ZX2
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BU of 6zx2 by Molmil
OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution
Descriptor: PROLINE, SULFATE ION, Uridine 5'-monophosphate synthase, ...
Authors:Tittmann, K, Rindfleisch, S, Schimdt, T.
Deposit date:2020-07-29
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7AM9
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BU of 7am9 by Molmil
OMPD-domain of human UMPS in complex with the substrate OMP at 0.99 Angstroms resolution
Descriptor: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Tittmann, K, Rindfleisch, S, Krull, M.
Deposit date:2020-10-08
Release date:2021-11-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
4JQ9
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BU of 4jq9 by Molmil
Dihydrolipoyl dehydrogenase of Escherichia coli pyruvate dehydrogenase complex
Descriptor: CHLORIDE ION, Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Tietzel, M, Neumann, P, Meyer, D, Ficner, R, Tittmann, K.
Deposit date:2013-03-20
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Dihydrolipoyl dehydrogenase of Escherichia coli pyruvate dehydrogenase complex
TO BE PUBLISHED
3MOS
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BU of 3mos by Molmil
The structure of human Transketolase
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, SODIUM ION, ...
Authors:Parthier, C, Tittmann, K.
Deposit date:2010-04-23
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of human transketolase and new insights into its mode of action.
J.Biol.Chem., 285, 2010
5HHT
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BU of 5hht by Molmil
Crystal structure of E. coli transketolase triple variant Ser385Tyr/Asp469Thr/Arg520Gln
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, THIAMINE DIPHOSPHATE, ...
Authors:Dai, S, Tittmann, K.
Deposit date:2016-01-11
Release date:2016-11-02
Last modified:2021-08-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.
Sci Rep, 6, 2016
8WA8
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BU of 8wa8 by Molmil
Human transketolase in complex with phosphite
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, PHOSPHITE ION, ...
Authors:Liu, Z, Tittmann, K, Dai, S.
Deposit date:2023-09-07
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis
Acs Catalysis, 14, 2024
8WAA
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BU of 8waa by Molmil
Human transketolase soaked with donor ketose D-xylulose
Descriptor: 1,2-ETHANEDIOL, 2-[3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-2-(1,2-DIHYDROXYETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ...
Authors:Liu, Z, Dai, S, Tittmann, K.
Deposit date:2023-09-07
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis
Acs Catalysis, 14, 2024
8WA7
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BU of 8wa7 by Molmil
E.coli transketolase soaked with donor ketose D-fructose
Descriptor: 1,2-ETHANEDIOL, 2-[3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-2-(1,2-DIHYDROXYETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, GLYCEROL, ...
Authors:Liu, Z, Dai, S, Tittmann, K.
Deposit date:2023-09-07
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis
Acs Catalysis, 14, 2024
8WA9
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BU of 8wa9 by Molmil
Human transketolase soaked with donor ketose D-fructose
Descriptor: 1,2-ETHANEDIOL, 2-[3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-2-(1,2-DIHYDROXYETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ...
Authors:Liu, Z, Tittmann, K, Dai, S.
Deposit date:2023-09-07
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis
Acs Catalysis, 14, 2024
6TJ9
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BU of 6tj9 by Molmil
Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine and substrate xylulose 5-phosphate
Descriptor: 1,2-ETHANEDIOL, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, 5-O-phosphono-D-xylulose, ...
Authors:Rabe von Pappenheim, F, Tittmann, K.
Deposit date:2019-11-25
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine.
Nat.Chem.Biol., 16, 2020
6TJ8
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BU of 6tj8 by Molmil
Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine diphosphate
Descriptor: 1,2-ETHANEDIOL, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, CALCIUM ION, ...
Authors:Rabe von Pappenheim, F, Tittmann, K.
Deposit date:2019-11-25
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (0.921 Å)
Cite:Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine.
Nat.Chem.Biol., 16, 2020
4XZ9
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BU of 4xz9 by Molmil
Transaldolase variant E60Q/F132Y from T. acidophilum in complex with DHA Schiff base and G3P
Descriptor: 1,3-PROPANDIOL, ACETATE ION, GLYCEROL, ...
Authors:Sautner, V, Tittmann, K.
Deposit date:2015-02-04
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Converting Transaldolase into Aldolase through Swapping of the Multifunctional Acid-Base Catalyst: Common and Divergent Catalytic Principles in F6P Aldolase and Transaldolase.
Biochemistry, 54, 2015
4ZP1
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BU of 4zp1 by Molmil
Crystal structure of Zymomonas mobilis pyruvate decarboxylase variant Glu473Ala
Descriptor: GLYCEROL, MAGNESIUM ION, NICKEL (II) ION, ...
Authors:Wechsler, C, Neumann, P, Tittmann, K.
Deposit date:2015-05-07
Release date:2015-11-04
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot.
Chembiochem, 16, 2015

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PDB entries from 2024-03-27

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