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1YOW
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BU of 1yow by Molmil
human Steroidogenic Factor 1 LBD with bound Co-factor Peptide
Descriptor: PHOSPHATIDYL ETHANOL, Steroidogenic factor 1, TIF2 peptide
Authors:Krylova, I.N, Sablin, E.P, Xu, R.X, Waitt, G.M, Juzumiene, D, Williams, J.D, Ingraham, H.A, Willson, T.M, Williams, S.P, Montana, V, Madauss, K.P, Moore, J, Bynum, J.M, Lebedeva, L, MacKay, J.A, Suzawa, M, Guy, R.K, Thornton, J.W.
Deposit date:2005-01-28
Release date:2005-05-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
4FN9
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BU of 4fn9 by Molmil
X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, GLYCEROL, ...
Authors:Colucci, J.K, Ortlund, E.A, Thornton, J.W.
Deposit date:2012-06-19
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet., 8, 2012
1YOK
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BU of 1yok by Molmil
crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol
Descriptor: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Nuclear receptor coactivator 2, Orphan nuclear receptor NR5A2
Authors:Krylova, I.N, Sablin, E.P, Moore, J, Xu, R.X, Waitt, G.M, MacKay, J.A, Juzumiene, D, Bynum, J.M, Madauss, K, Montana, V, Lebedeva, L, Suzawa, M, Williams, J.D, Williams, S.P, Guy, R.K, Thornton, J.W, Fletterick, R.J, Willson, T.M, Ingraham, H.A.
Deposit date:2005-01-27
Release date:2005-07-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell(Cambridge,Mass.), 120, 2005
4LY7
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BU of 4ly7 by Molmil
Ancestral RNase H
Descriptor: Ribonuclease H, SULFATE ION
Authors:Hart, K.M, Harms, M.J, Schmidt, B.H, Elya, C, Thornton, J.W, Marqusee, S.
Deposit date:2013-07-30
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Thermodynamic system drift in protein evolution.
Plos Biol., 12, 2014
2Q1H
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BU of 2q1h by Molmil
Ancestral Corticoid Receptor in Complex with Aldosterone
Descriptor: ALDOSTERONE, AncCR, GLYCEROL, ...
Authors:Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W.
Deposit date:2007-05-24
Release date:2007-09-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
2Q3Y
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BU of 2q3y by Molmil
Ancestral Corticiod Receptor in Complex with DOC
Descriptor: Ancestral Corticiod Receptor, DESOXYCORTICOSTERONE, GLYCEROL, ...
Authors:Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W.
Deposit date:2007-05-30
Release date:2007-09-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis
Science, 317, 2007
4FNE
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BU of 4fne by Molmil
X-ray Crystal structure of the Ancestral 3-keto steroid receptor - DOC complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, DESOXYCORTICOSTERONE, ...
Authors:Ortlund, E.A, Colucci, J.K, Thornton, J, Eick, G, Harms, M.
Deposit date:2012-06-19
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet, 8, 2012
3GN8
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BU of 3gn8 by Molmil
X-ray Crystal Structure of AncGR2 in Complex with Dexamethasone
Descriptor: DEXAMETHASONE, Glucocorticoid receptor 2, Nuclear receptor coactivator 2
Authors:Ortlund, E.A.
Deposit date:2009-03-16
Release date:2009-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
Nature, 461, 2009
1YMT
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BU of 1ymt by Molmil
Mouse SF-1 LBD
Descriptor: 1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL, Nuclear receptor 0B2, Steroidogenic factor 1
Authors:Krylova, I.N, Sablin, E.P, Moore, J, Xu, R.X, Waitt, G.M, Juzumiene, D, Bynum, J.M, Fletterick, R.J, Willson, T.M, Ingraham, H.A.
Deposit date:2005-01-21
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
3RY9
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BU of 3ry9 by Molmil
Crystal Structure of the Resurrected Ancestral Glucocorticoid Receptor 1 in complex with DOC
Descriptor: Ancestral Glucocorticoid Receptor 1, DESOXYCORTICOSTERONE, GLYCEROL, ...
Authors:Ortlund, E.A.
Deposit date:2011-05-11
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.
PLoS Genet, 7, 2011
6ONB
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BU of 6onb by Molmil
Crystal Structure of the ZIG-8-RIG-5 IG1-IG1 heterodimer, monoclinic form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NeuRonal IgCAM-5, ...
Authors:Cheng, S, Kurleto, J.D, Ozkan, E.
Deposit date:2019-04-20
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 116, 2019
6ON9
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BU of 6on9 by Molmil
Crystal Structure of the ZIG-8-RIG-5 IG1-IG1 heterodimer, tetragonal form
Descriptor: NeuRonal IgCAM-5, SODIUM ION, SULFATE ION, ...
Authors:Cheng, S, Kurleto, J.D, Ozkan, E.
Deposit date:2019-04-20
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 116, 2019
6ON6
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BU of 6on6 by Molmil
Crystal Structure of the RIG-5 IG1 homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, NeuRonal IgCAM-5
Authors:Cheng, S, Kurleto, J.D, Ozkan, E.
Deposit date:2019-04-20
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.423 Å)
Cite:Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 116, 2019
6PLL
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BU of 6pll by Molmil
Crystal structure of the ZIG-8 IG1 homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Zwei Ig domain protein zig-8
Authors:Cheng, S, Ozkan, E.
Deposit date:2019-07-01
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5CC1
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BU of 5cc1 by Molmil
S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex
Descriptor: DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Weikum, E.A, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBX
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BU of 5cbx by Molmil
AncGR DNA Binding Domain - (+)GRE Complex
Descriptor: AncGR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBY
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BU of 5cby by Molmil
AncGR2 DNA Binding Domain - (+)GRE Complex
Descriptor: AncGR2 DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBZ
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BU of 5cbz by Molmil
AncMR DNA Binding Domain - (+)GRE Complex
Descriptor: AncMR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CC0
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BU of 5cc0 by Molmil
AncSR2 - TSLP nGRE complex
Descriptor: AncSR2 DNA Binding Domain, DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), ...
Authors:Hudson, W.H, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
7LTW
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BU of 7ltw by Molmil
Crystal structure of the mouse Kirrel2 D1 homodimer
Descriptor: Kin of IRRE-like protein 2, SODIUM ION
Authors:Roman, C.A, Pak, J.S, Wang, J, Ozkan, E.
Deposit date:2021-02-20
Release date:2021-11-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
Cell Rep, 37, 2021
7LU6
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BU of 7lu6 by Molmil
Crystal structure of the mouse Kirrel3 D1 homodimer
Descriptor: Kin of IRRE-like protein 3, SODIUM ION
Authors:Roman, C.A, Pak, J.S, Wang, J, Ozkan, E.
Deposit date:2021-02-21
Release date:2021-11-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
Cell Rep, 37, 2021
4N1Y
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BU of 4n1y by Molmil
Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain
Descriptor: Estrogen receptor
Authors:Ortlund, E.O.
Deposit date:2013-10-04
Release date:2014-02-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.
PLoS Genet, 10, 2014
4OND
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BU of 4ond by Molmil
Ancestral Steroid Receptor 2 DBD helix mutant - ERE DNA complex
Descriptor: 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*G)-3', Ancestral SR2 Helix Mutant, ...
Authors:Ortlund, E.O, Murphy, M.N.
Deposit date:2014-01-28
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.253 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OOR
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BU of 4oor by Molmil
Ancestral Steroid Receptor 2 DNA binding domain in complex with a steroid response element
Descriptor: 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3', Ancestral Steroid Receptor 2 DNA binding domain, ...
Authors:Ortlund, E.O, Murphy, M.N.
Deposit date:2014-02-03
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OLN
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BU of 4oln by Molmil
Ancestral Steroid Receptor 1 in complex with estrogen response element DNA
Descriptor: 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*GP*A)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*GP*G)-3', AncSR1, ...
Authors:Ortlund, E.O, Murphy, M.N.
Deposit date:2014-01-24
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014

 

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