Author results

1YOK
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CRYSTAL STRUCTURE OF HUMAN LRH-1 BOUND WITH TIF-2 PEPTIDE AND PHOSPHATIDYLGLYCEROL
Descriptor:Orphan nuclear receptor NR5A2, Nuclear receptor coactivator 2, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE
Authors:Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., MacKay, J.A., Juzumiene, D., Bynum, J.M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J.D., Williams, S.P., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
Deposit date:2005-01-27
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell(Cambridge,Mass.), 120, 2005
1YOW
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HUMAN STEROIDOGENIC FACTOR 1 LBD WITH BOUND CO-FACTOR PEPTIDE
Descriptor:Steroidogenic factor 1, TIF2 peptide, PHOSPHATIDYL ETHANOL
Authors:Krylova, I.N., Sablin, E.P., Xu, R.X., Waitt, G.M., Juzumiene, D., Williams, J.D., Ingraham, H.A., Willson, T.M., Williams, S.P., Montana, V., Madauss, K.P., Moore, J., Bynum, J.M., Lebedeva, L., MacKay, J.A., Suzawa, M., Guy, R.K., Thornton, J.W.
Deposit date:2005-01-28
Release date:2005-05-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
2Q1H
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ANCESTRAL CORTICOID RECEPTOR IN COMPLEX WITH ALDOSTERONE
Descriptor:AncCR, SODIUM ION, ALDOSTERONE, ...
Authors:Ortlund, E.A., Bridgham, J.T., Redinbo, M.R., Thornton, J.W.
Deposit date:2007-05-24
Release date:2007-09-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
2Q3Y
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ANCESTRAL CORTICIOD RECEPTOR IN COMPLEX WITH DOC
Descriptor:Ancestral Corticiod Receptor, Nuclear receptor 0B2, DESOXYCORTICOSTERONE, ...
Authors:Ortlund, E.A., Bridgham, J.T., Redinbo, M.R., Thornton, J.W.
Deposit date:2007-05-30
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis
Science, 317, 2007
4FN9
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X-RAY CRYSTAL STRUCTURE OF THE ANCESTRAL 3-KETO STEROID RECEPTOR - PROGESTERONE COMPLEX
Descriptor:Steroid receptor 2, PROGESTERONE, GLYCEROL, ...
Authors:Colucci, J.K., Ortlund, E.A., Thornton, J.W.
Deposit date:2012-06-19
Release date:2012-12-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet., 8, 2012
4LY7
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ANCESTRAL RNASE H
Descriptor:Ribonuclease H, SULFATE ION
Authors:Hart, K.M., Harms, M.J., Schmidt, B.H., Elya, C., Thornton, J.W., Marqusee, S.
Deposit date:2013-07-30
Release date:2014-11-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Thermodynamic system drift in protein evolution.
Plos Biol., 12, 2014
4FNE
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X-RAY CRYSTAL STRUCTURE OF THE ANCESTRAL 3-KETO STEROID RECEPTOR - DOC COMPLEX
Descriptor:Steroid receptor 2, DESOXYCORTICOSTERONE, SULFATE ION, ...
Authors:Ortlund, E.A., Colucci, J.K., Thornton, J., Eick, G., Harms, M.
Deposit date:2012-06-19
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet, 8, 2012
1YMT
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MOUSE SF-1 LBD
Descriptor:Steroidogenic factor 1, Nuclear receptor 0B2, 1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL
Authors:Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., Juzumiene, D., Bynum, J.M., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
Deposit date:2005-01-21
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
2Q1V
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ANCESTRAL CORTICOID RECEPTOR IN COMPLEX WITH CORTISOL
Descriptor:AncCR, 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, GLYCEROL
Authors:Ortlund, E.A., Redinbo, M.R.
Deposit date:2007-05-25
Release date:2007-09-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
3GN8
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X-RAY CRYSTAL STRUCTURE OF ANCGR2 IN COMPLEX WITH DEXAMETHASONE
Descriptor:Glucocorticoid receptor 2, Nuclear receptor coactivator 2, DEXAMETHASONE
Authors:Ortlund, E.A.
Deposit date:2009-03-16
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
Nature, 461, 2009
3RY9
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CRYSTAL STRUCTURE OF THE RESURRECTED ANCESTRAL GLUCOCORTICOID RECEPTOR 1 IN COMPLEX WITH DOC
Descriptor:Ancestral Glucocorticoid Receptor 1, GLYCEROL, DESOXYCORTICOSTERONE, ...
Authors:Ortlund, E.A.
Deposit date:2011-05-11
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.
PLoS Genet, 7, 2011
4N1Y
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CRYSTAL STRUCTURE OF THE PACIFIC OYSTER ESTROGEN RECEPTOR LIGAND BINDING DOMAIN
Descriptor:Estrogen receptor
Authors:Ortlund, E.O.
Deposit date:2013-10-04
Release date:2014-02-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.
PLoS Genet, 10, 2014
4OLN
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ANCESTRAL STEROID RECEPTOR 1 IN COMPLEX WITH ESTROGEN RESPONSE ELEMENT DNA
Descriptor:AncSR1, 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*GP*A)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*GP*G)-3', ...
Authors:Ortlund, E.O., Murphy, M.N.
Deposit date:2014-01-24
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OND
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ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
Descriptor:Ancestral SR2 Helix Mutant, 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*G)-3', ...
Authors:Ortlund, E.O., Murphy, M.N.
Deposit date:2014-01-28
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.253 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OOR
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ANCESTRAL STEROID RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH A STEROID RESPONSE ELEMENT
Descriptor:Ancestral Steroid Receptor 2 DNA binding domain, 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3', ...
Authors:Ortlund, E.O., Murphy, M.N.
Deposit date:2014-02-03
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OV7
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ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - SRE DNA COMPLEX
Descriptor:Ancestral Steroid Receptor 2 DBD helix mutant, 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3', ...
Authors:Ortlund, E.A.
Deposit date:2014-02-20
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
5CBX
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ANCGR DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:AncGR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBY
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ANCGR2 DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:AncGR2 DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBZ
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ANCMR DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:AncMR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CC0
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ANCSR2 - TSLP NGRE COMPLEX
Descriptor:AncSR2 DNA Binding Domain, DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CC1
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S425G GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Weikum, E.A., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016