Author results

2BCJ
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CRYSTAL STRUCTURE OF G PROTEIN-COUPLED RECEPTOR KINASE 2 IN COMPLEX WITH GALPHA-Q AND GBETAGAMMA SUBUNITS
Descriptor:G-protein-coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tesmer, J.J.G.
Deposit date:2005-10-19
Release date:2005-12-20
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.061 Å)
Cite:Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex
Science, 310, 2005
1CS4
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
Descriptor:TYPE V ADENYLATE CYCLASE, TYPE II ADENYLATE CYCLASE, GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ...
Authors:Tesmer, J.J.G., Dessauer, C.A., Sunahara, R.K., Johnson, R.A., Gilman, A.G., Sprang, S.R.
Deposit date:1999-08-16
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
1GPM
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ESCHERICHIA COLI GMP SYNTHETASE COMPLEXED WITH AMP AND PYROPHOSPHATE
Descriptor:GMP SYNTHETASE, PHOSPHATE ION, PYROPHOSPHATE 2-, ...
Authors:Tesmer, J.J.G.
Deposit date:1995-04-04
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Nat.Struct.Biol., 3, 1996
1OMW
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN G PROTEIN-COUPLED RECEPTOR KINASE 2 AND HETEROTRIMERIC G PROTEIN BETA 1 AND GAMMA 2 SUBUNITS
Descriptor:G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit
Authors:Lodowski, D.T., Pitcher, J.A., Capel, W.D., Lefkowitz, R.J., Tesmer, J.J.G.
Deposit date:2003-02-26
Release date:2003-06-03
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Keeping G proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G-Beta-Gamma
Science, 300, 2003
1YM7
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G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2)
Descriptor:Beta-adrenergic receptor kinase 1
Authors:Lodowski, D.T., Barnhill, J.F., Pyskadlo, R.M., Ghirlando, R., Sterne-Marr, R., Tesmer, J.J.G.
Deposit date:2005-01-20
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:The role of Gbetagamma and domain interfaces in the activation of G protein-coupled receptor kinase 2
Biochemistry, 44, 2005
5TXF
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CRYSTAL STRUCTURE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT) IN A CLOSED CONFORMATION
Descriptor:Phosphatidylcholine-sterol acyltransferase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Manthei, K.A., Glukhova, A., Tesmer, J.J.G.
Deposit date:2016-11-16
Release date:2017-10-25
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.
J. Biol. Chem., 292, 2017
5W5V
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TBK1 CO-CRYSTAL STRUCTURE WITH AMLEXANOX
Descriptor:Serine/threonine-protein kinase TBK1, 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
Authors:Beyett, T.S., Tesmer, J.J.G.
Deposit date:2017-06-15
Release date:2018-06-27
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (3.645 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
5WG3
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HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG258748
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Bouley, R., Tesmer, J.J.G.
Deposit date:2017-07-13
Release date:2017-12-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.896 Å)
Cite:Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol. Pharmacol., 92, 2017
5WG4
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HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG257284
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Bouley, R., Tesmer, J.J.G.
Deposit date:2017-07-13
Release date:2017-12-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol. Pharmacol., 92, 2017
5WG5
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HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG224061
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Bouley, R., Tesmer, J.J.G.
Deposit date:2017-07-13
Release date:2017-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol. Pharmacol., 92, 2017
6BNM
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CRYSTAL STRUCTURE OF THE P-REX2 PH DOMAIN
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein, CHLORIDE ION
Authors:Cash, J.N., Sharma, P.V., Tesmer, J.J.G.
Deposit date:2017-11-17
Release date:2018-11-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the P-Rex2 PH domain
To Be Published
6BNY
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TBK1 IN COMPLEX WITH TETRAZOLE ANALOG OF AMLEXANOX
Descriptor:Serine/threonine-protein kinase TBK1, 2-amino-7-(propan-2-yl)-3-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridin-5-one
Authors:Beyett, T.S., Tesmer, J.J.G.
Deposit date:2017-11-17
Release date:2018-09-26
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.341 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
6BOD
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TBK1 IN COMPLEX WITH ETHYL ESTER ANALOG OF AMLEXANOX
Descriptor:Serine/threonine-protein kinase TBK1, ethyl 2-amino-5-oxo-7-(propan-2-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate
Authors:Beyett, T.S., Tesmer, J.J.G.
Deposit date:2017-11-19
Release date:2018-09-26
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
6BOE
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TBK1 IN COMPLEX WITH AMIDE-COUPLED TETRAZOLE ANALOG OF AMLEXANOX
Descriptor:Serine/threonine-protein kinase TBK1, 2-amino-5-oxo-7-(propan-2-yl)-N-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
Authors:Beyett, T.S., Tesmer, J.J.G.
Deposit date:2017-11-19
Release date:2018-09-26
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol., 94, 2018
6C2Y
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HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG257142
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Bouley, R., Tesmer, J.J.G.
Deposit date:2018-01-09
Release date:2018-04-25
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6CQ0
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TBK1 IN COMPLEX WITH DIMETHYL AMINO ANALOG OF AMLEXANOX
Descriptor:Serine/threonine-protein kinase TBK1, 2-amino-7-[3-(dimethylamino)propyl]-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Authors:Beyett, T.S., Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6CQ4
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TBK1 IN COMPLEX WITH CYCLOHEXYL ANALOG OF AMLEXANOX
Descriptor:Serine/threonine-protein kinase TBK1, 2-amino-7-(4,4-difluorocyclohexyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Authors:Beyett, T.S., Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
6CQ5
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TBK1 IN COMPLEX WITH SULFONE ANALOG OF AMLEXANOX
Descriptor:Serine/threonine-protein kinase TBK1, 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Authors:Beyett, T.S., Tesmer, J.J.G.
Deposit date:2018-03-14
Release date:2018-12-05
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.354 Å)
Cite:Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Bioorg. Med. Chem., 26, 2018
3KRW
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HUMAN GRK2 IN COMPLEX WITH GBETGAMMA SUBUNITS AND BALANOL (SOAK)
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tesmer, J.J.G., Tesmer, V.M.
Deposit date:2009-11-19
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
3KRX
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HUMAN GRK2 IN COMPLEX WITH GBETGAMMA SUBUNITS AND BALANOL (CO-CRYSTAL)
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tesmer, J.J.G., Tesmer, V.M.
Deposit date:2009-11-19
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
3UZS
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STRUCTURE OF THE C13.28 RNA APTAMER BOUND TO THE G PROTEIN-COUPLED RECEPTOR KINASE 2-HETEROTRIMERIC G PROTEIN BETA 1 AND GAMMA 2 SUBUNIT COMPLEX
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tesmer, J.J.G., Tesmer, V.M.
Deposit date:2011-12-07
Release date:2012-07-11
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (4.52 Å)
Cite:Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.
Structure, 20, 2012
3UZT
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STRUCTURE OF THE C13.18 RNA APTAMER IN COMPLEX WITH G PROTEIN-COUPLED RECEPTOR KINASE 2
Descriptor:Beta-adrenergic receptor kinase 1, C13.18 RNA Aptamer, MAGNESIUM ION
Authors:Tesmer, J.J.G., Tesmer, V.M.
Deposit date:2011-12-07
Release date:2012-07-11
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.
Structure, 20, 2012
3CIK
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HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS
Descriptor:Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tesmer, J.J.G., Lodowski, D.T.
Deposit date:2008-03-11
Release date:2009-02-17
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
4EKC
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STRUCTURE OF HUMAN REGULATOR OF G PROTEIN SIGNALING 2 (RGS2) IN COMPLEX WITH MURINE GALPHA-Q(R183C)
Descriptor:Guanine nucleotide-binding protein G(q) subunit alpha, Regulator of G-protein signaling 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2012-04-09
Release date:2013-01-30
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (7.4 Å)
Cite:Structural and functional analysis of the regulator of G protein signaling 2-g alpha q complex.
Structure, 21, 2013
4EKD
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STRUCTURE OF HUMAN REGULATOR OF G PROTEIN SIGNALING 2 (RGS2) IN COMPLEX WITH MURINE GALPHA-Q(R183C)
Descriptor:Guanine nucleotide-binding protein G(q) subunit alpha, Regulator of G-protein signaling 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2012-04-09
Release date:2013-01-30
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural and functional analysis of the regulator of G protein signaling 2-g alpha q complex.
Structure, 21, 2013