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2QUR
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CRYSTAL STRUCTURE OF F327A/K285P MUTANT OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, 20-mer fragment from cAMP-dependent protein kinase inhibitor alpha, ...
著者Taylor, S.S., Yang, J., Wu, J.
登録日2007-08-06
公開日2008-07-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Contribution of non-catalytic core residues to activity and regulation in protein kinase A.
J.Biol.Chem., 284, 2009
1CMK
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CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS
分子名称:cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP-dependent protein kinase inhibitor, alpha form, ...
著者Zheng, J., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Sowadski, J.M., Ten Eyck, L.F.
登録日1993-11-18
公開日1994-05-31
最終更新日2012-07-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Protein Sci., 2, 1993
1BX6
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CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:CAMP-DEPENDENT PROTEIN KINASE, BALANOL
著者Narayana, N., Xuong, N.-H., Ten Eyck, L.F., Taylor, S.S.
登録日1998-10-13
公開日1999-04-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry, 38, 1999
1CTP
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STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION
分子名称:cAMP-DEPENDENT PROTEIN KINASE, cAMP-dependent protein kinase inhibitor, alpha form, ...
著者Karlsson, R., Zheng, J., Xuong, N.H., Taylor, S.S., Sowadski, J.M.
登録日1993-04-08
公開日1994-01-31
最終更新日2012-07-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation.
Acta Crystallogr.,Sect.D, 49, 1993
1ATP
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2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR
分子名称:cAMP-DEPENDENT PROTEIN KINASE, PEPTIDE INHIBITOR PKI(5-24), MANGANESE (II) ION, ...
著者Zheng, J., Trafny, E.A., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Teneyck, L.F., Sowadski, J.M.
登録日1993-01-08
公開日1993-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor.
Acta Crystallogr.,Sect.D, 49, 1993
1BKX
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A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY
分子名称:CAMP-DEPENDENT PROTEIN KINASE, ADENOSINE-5'-MONOPHOSPHATE
著者Narayana, N., Cox, S., Xuong, N., Ten Eyck, L.F., Taylor, S.S.
登録日1997-07-01
公開日1998-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.
Structure, 5, 1997
1FMO
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CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE
分子名称:CAMP-DEPENDENT PROTEIN KINASE, HEAT STABLE RABBIT SKELETAL MUSCLE INHIBITOR PROTEIN, ADENOSINE
著者Narayana, N., Cox, S., Shaltiel, S., Taylor, S.S., Xuong, N.-H.
登録日1997-07-08
公開日1998-01-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Biochemistry, 36, 1997
1J3H
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CRYSTAL STRUCTURE OF APOENZYME CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Akamine, P., Madhusudan, Wu, J., Xuong, N.H., Ten Eyck, L.F., Taylor, S.S.
登録日2003-01-31
公開日2003-03-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Dynamic Features of cAMP-dependent Protein Kinase Revealed by Apoenzyme Crystal Structure
J.Mol.Biol., 327, 2003
1APM
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2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT
分子名称:cAMP-DEPENDENT PROTEIN KINASE, PEPTIDE INHIBITOR PKI(5-24), N-OCTANE
著者Knighton, D.R., Bell, S.M., Zheng, J., Teneyck, L.F., Xuong, N.-H., Taylor, S.S., Sowadski, J.M.
登録日1993-01-18
公開日1993-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent.
Acta Crystallogr.,Sect.D, 49, 1993
1L3R
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CRYSTAL STRUCTURE OF A TRANSITION STATE MIMIC OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ...
著者Madhusudan, Akamine, P., Xuong, N.-H., Taylor, S.S.
登録日2002-02-28
公開日2002-03-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase.
Nat.Struct.Biol., 9, 2002
1RDQ
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HYDROLYSIS OF ATP IN THE CRYSTAL OF Y204A MUTANT OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, ...
著者Yang, J., Ten Eyck, L.F., Xuong, N.H., Taylor, S.S.
登録日2003-11-05
公開日2004-04-13
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Crystal Structure of a cAMP-dependent Protein Kinase Mutant at 1.26A: New Insights into the Catalytic Mechanism.
J.Mol.Biol., 336, 2004
1JBP
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A SUBSTRATE PEPTIDE, ADP AND DETERGENT
分子名称:CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ...
著者Madhusudan, Trafny, E.A., Xuong, N.H., Adams, J.A., Ten Eyck, L.F., Taylor, S.S., Sowadski, J.M.
登録日2001-06-06
公開日2001-06-27
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer.
Protein Sci., 3, 1994
1JLU
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PHOSPHORYLATED SUBSTRATE PEPTIDE AND DETERGENT
分子名称:AMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ...
著者Madhusudan, Trafny, E.A., Xuong, N.-H., Adams, J.A., Ten Eyck, L.F., Taylor, S.S., Sowadski, J.M.
登録日2001-07-16
公開日2001-08-01
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer.
Protein Sci., 3, 1994
2CPK
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE
分子名称:cAMP-DEPENDENT PROTEIN KINASE, CATALYTIC SUBUNIT, PEPTIDE INHIBITOR 20-MER
著者Knighton, D.R., Zheng, J., Teneyck, L.F., Ashford, V.A., Xuong, N.-H., Taylor, S.S., Sowadski, J.M.
登録日1992-10-21
公開日1993-01-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Science, 253, 1991
1CX4
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CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT TYPE II BETA, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Diller, T.C., Xuong, N.H., Taylor, S.S.
登録日1999-08-28
公開日2001-03-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit.
Structure, 9, 2001
1RE8
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CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 2
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXYBENZOYL)BENZOATE, ...
著者Akamine, P., Madhusudan, Brunton, L.L., Ou, H.D., Canaves, J.M., Xuong, N.H., Taylor, S.S.
登録日2003-11-06
公開日2004-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
1REJ
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CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 1
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-HYDROXYBENZOATE
著者Akamine, P., Madhusudan, Brunton, L.L., Ou, H.D., Canaves, J.M., Xuong, N.H., Taylor, S.S.
登録日2003-11-06
公開日2004-02-24
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
1REK
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CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 8
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(3-SEC-BUTYL-4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXY-5-METHOXYBENZOYL)BENZOATE, ...
著者Akamine, P., Madhusudan, Brunton, L.L., Ou, H.D., Canaves, J.M., Xuong, N.H., Taylor, S.S.
登録日2003-11-06
公開日2004-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
1NE4
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CRYSTAL STRUCTURE OF RP-CAMP BINDING R1A SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:cAMP-dependent protein kinase type I-alpha regulatory chain, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL
著者Wu, J., Jones, J.M., Xuong, N.H., Taylor, S.S.
登録日2002-12-10
公開日2004-01-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
1NE6
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CRYSTAL STRUCTURE OF SP-CAMP BINDING R1A SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:cAMP-dependent protein kinase type I-alpha regulatory chain, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL
著者Wu, J., Jones, J.M., Xuong, N.H., Taylor, S.S.
登録日2002-12-10
公開日2004-01-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
1RGS
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REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
分子名称:CAMP DEPENDENT PROTEIN KINASE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Su, Y., Dostmann, W.R.G., Herberg, F.W., Durick, K., Xuong, N.-H., Ten Eyck, L., Taylor, S.S., Varughese, K.I.
登録日1995-06-21
公開日1996-12-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Science, 269, 1995
1RL3
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CRYSTAL STRUCTURE OF CAMP-FREE R1A SUBUNIT OF PKA
分子名称:cAMP-dependent protein kinase type I-alpha regulatory chain, CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL
著者Wu, J., Brown, S., Xuong, N.-H., Taylor, S.S.
登録日2003-11-24
公開日2004-07-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.
Structure, 12, 2004
1SYK
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CRYSTAL STRUCTURE OF E230Q MUTANT OF CAMP-DEPENDENT PROTEIN KINASE REVEALS UNEXPECTED APOENZYME CONFORMATION
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit
著者Wu, J., Yang, J., Madhusudan, N., Xuong, N.H., Ten Eyck, L.F., Taylor, S.S.
登録日2004-04-01
公開日2005-05-17
最終更新日2017-02-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
Protein Sci., 14, 2005
2QCS
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A COMPLEX STRUCTURE BETWEEN THE CATALYTIC AND REGULATORY SUBUNIT OF PROTEIN KINASE A THAT REPRESENTS THE INHIBITED STATE
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type I-alpha regulatory subunit, ...
著者Kim, C., Cheng, C.Y., Saldanha, A.S., Taylor, S.S.
登録日2007-06-19
公開日2007-11-06
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
Cell(Cambridge,Mass.), 130, 2007
2QVS
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CRYSTAL STRUCTURE OF TYPE IIA HOLOENZYME OF CAMP-DEPENDENT PROTEIN KINASE
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type II-alpha regulatory subunit
著者Wu, J., Brown, S.H.J., von Daake, S., Taylor, S.S.
登録日2007-08-08
公開日2007-10-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Science, 318, 2007