Author results

2ANW
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EXPRESSION, CRYSTALLIZATION AND THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS
Descriptor:plasma kallikrein, light chain, BENZAMIDINE
Authors:Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J.R., Young, W.B., McGrath, M.E., Katz, B.A.
Deposit date:2005-08-11
Release date:2005-10-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
2ANY
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EXPRESSION, CRYSTALLIZATION AND THE THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS
Descriptor:plasma kallikrein, light chain, PHOSPHATE ION, ...
Authors:Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J.R., Young, W.B., McGrath, M.E., Katz, B.A.
Deposit date:2005-08-11
Release date:2005-10-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
3IYM
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BACKBONE TRACE OF THE CAPSID PROTEIN DIMER OF A FUNGAL PARTITIVIRUS FROM ELECTRON CRYOMICROSCOPY AND HOMOLOGY MODELING
Descriptor:Capsid protein
Authors:Tang, J., Pan, J., Havens, W.F., Ochoa, W.F., Li, H., Sinkovits, R.S., Guu, T.S.Y., Ghabrial, S.A., Nibert, M.L., Tao, J.Y., Baker, T.S.
Deposit date:2010-02-05
Release date:2010-07-28
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Backbone Trace of Partitivirus Capsid Protein from Electron Cryomicroscopy and Homology Modeling
Biophys.J., 99, 2010
3J0F
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SINDBIS VIRION
Descriptor:Capsid protein, E1 envelope glycoprotein, E2 envelope glycoprotein
Authors:Tang, J., Jose, J., Zhang, W., Chipman, P., Kuhn, R.J., Baker, T.S.
Deposit date:2011-07-08
Release date:2011-10-12
Last modified:2012-05-30
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Molecular Links between the E2 Envelope Glycoprotein and Nucleocapsid Core in Sindbis Virus.
J.Mol.Biol., 414, 2011
5GR8
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CRYSTAL STRUCTURE OF PEPR1-ATPEP1
Descriptor:Leucine-rich repeat receptor-like protein kinase PEPR1, Elicitor peptide 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Chai, J.J., Tang, J.
Deposit date:2016-08-08
Release date:2016-12-14
Method:X-RAY DIFFRACTION (2.587 Å)
Cite:Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1
Cell Res., 25, 2015
1M1C
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STRUCTURE OF THE L-A VIRUS
Descriptor:Major coat protein
Authors:Naitow, H., Tang, J., Canady, M., Wickner, R.B., Johnson, J.E.
Deposit date:2002-06-18
Release date:2002-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism.
Nat.Struct.Biol., 9, 2002
1DDJ
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CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN
Descriptor:PLASMINOGEN
Authors:Wang, X., Terzyan, S., Tang, J., Loy, J., Lin, X., Zhang, X.
Deposit date:1999-11-10
Release date:2000-02-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.
J.Mol.Biol., 295, 2000
1R42
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NATIVE HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
Descriptor:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
Deposit date:2003-10-07
Release date:2004-02-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004
1R4L
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INHIBITOR BOUND HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
Descriptor:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
Deposit date:2003-10-07
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004
1AXA
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ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Hartsuck, J.A., Foundling, S., Ermolieff, J., Tang, J.
Deposit date:1997-10-13
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.
Protein Sci., 7, 1998
1CJY
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HUMAN CYTOSOLIC PHOSPHOLIPASE A2
Descriptor:PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2), CALCIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S.
Deposit date:1999-04-20
Release date:2000-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
Cell(Cambridge,Mass.), 97, 1999
3RE9
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CRYSTAL STRUCTURE OF SORTASEC1 FROM STREPTOCOCCUS SUIS
Descriptor:Sortase-like protein
Authors:Lu, G., Qi, J., Gao, F., Yan, J., Tang, J., Gao, G.F.
Deposit date:2011-04-04
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel "open-form" structure of sortaseC from Streptococcus suis
Proteins, 2011
1F42
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THE P40 DOMAIN OF HUMAN INTERLEUKIN-12
Descriptor:INTERLEUKIN-12 BETA CHAIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Yoon, C., Johnston, S.C., Tang, J., Tobin, J.F., Somers, W.S.
Deposit date:2000-06-07
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.
EMBO J., 19, 2000
1F45
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HUMAN INTERLEUKIN-12
Descriptor:INTERLEUKIN-12 BETA CHAIN, INTERLEUKIN-12 ALPHA CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yoon, C., Johnston, S.C., Tang, J., Tobin, J.F., Somers, W.S.
Deposit date:2000-06-07
Release date:2001-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.
EMBO J., 19, 2000
3QJZ
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CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH BENZOTHIAZOLE 1
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-{6-[2-(methylsulfanyl)pyrimidin-4-yl]-1,3-benzothiazol-2-yl}acetamide, SULFATE ION
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2011-01-31
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
3QK0
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CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH BENZOTHIAZOLE 82
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2011-01-31
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
1A9M
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G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Zhang, X.-J., Foundling, S., Hartsuck, J.A., Tang, J.
Deposit date:1998-04-08
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs.
FEBS Lett., 420, 1997
1FB7
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CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
Descriptor:HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
Authors:Hong, L., Zhang, X.C., Hartsuck, J.A., Tang, J.
Deposit date:2000-07-14
Release date:2000-12-13
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance.
Protein Sci., 9, 2000
1FKN
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STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR
Descriptor:MEMAPSIN 2, inhibitor
Authors:Hong, L., Koelsch, G., Lin, X., Wu, S., Terzyan, S., Ghosh, A., Zhang, X.C., Tang, J.
Deposit date:2000-08-09
Release date:2000-10-09
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
Science, 290, 2000
1GNM
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HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Treharne, A., Hartsuck, J.A., Foundling, S., Tang, J.
Deposit date:1996-05-04
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.
Biochemistry, 35, 1996
1GNN
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HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR)
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Treharne, A., Hartsuck, J.A., Foundling, S., Tang, J.
Deposit date:1996-05-04
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.
Biochemistry, 35, 1996
1GNO
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HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR)
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Treharne, A., Hartsuck, J.A., Foundling, S., Tang, J.
Deposit date:1996-05-04
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.
Biochemistry, 35, 1996
1L4D
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CRYSTAL STRUCTURE OF MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX
Descriptor:PLASMINOGEN, STREPTOKINASE, SULFATE ION
Authors:Wakeham, N., Terzyan, S., Zhai, P., Loy, J.A., Tang, J., Zhang, X.C.
Deposit date:2002-03-04
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Effects of deletion of streptokinase residues 48-59 on plasminogen activation
PROTEIN ENG., 15, 2002
1L4Z
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X-RAY CRYSTAL STRUCTURE OF THE COMPLEX OF MICROPLASMINOGEN WITH ALPHA DOMAIN OF STREPTOKINASE IN THE PRESENCE CADMIUM IONS
Descriptor:Plasminogen, Streptokinase, CADMIUM ION
Authors:Wakeham, N., Terzyan, S., Zhai, P., Loy, J.A., Tang, J., Zhang, X.C.
Deposit date:2002-03-06
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Effects of deletion of streptokinase residues 48-59 on plasminogen activation.
PROTEIN ENG., 15, 2002
1M4H
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CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR OM00-3
Descriptor:beta-Secretase, Inhibitor OM00-3
Authors:Hong, L., Turner, R.T., Koelsch, G., Ghosh, A.K., Tang, J.
Deposit date:2002-07-02
Release date:2002-08-28
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Memapsin 2 (beta-Secretase) in Complex with Inhibitor OM00-3
Biochemistry, 41, 2002