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316D
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SELECTIVITY OF F8-ACTINOMYCIN D FOR RNA:DNA HYBRIDS AND ITS ANTI-LEUKEMIA ACTIVITY
Descriptor:DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'), 8-FLUORO-ACTINOMYCIN D
Authors:Takusagawa, F., Takusagawa, K.T., Carlson, R.G., Weaver, R.F.
Deposit date:1997-03-05
Release date:1997-11-05
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Selectivity of F8-Actinomycin D for RNA:DNA Hybrids and its Anti-Leukemia Activity.
Bioorg.Med.Chem., 5, 1997
1KIA
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CRYSTAL STRUCTURE OF GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE AND ACETATE
Descriptor:Glycine N-methyltransferase, ACETATE ION, S-ADENOSYLMETHIONINE
Authors:Takusagawa, F., Huang, Y.
Deposit date:2001-12-02
Release date:2003-06-10
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of glycine N-methyltransferase complexed with S-adenosylmethionine and acetate
To be Published
1MXA
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S-ADENOSYLMETHIONINE SYNTHETASE WITH PPI
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1MXB
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S-ADENOSYLMETHIONINE SYNTHETASE WITH ADP
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1MXC
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S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1XRA
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Misaki, S., Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRB
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S-ADENOSYLMETHIONINE SYNTHETASE (MAT, ATP: L-METHIONINE S-ADENOSYLTRANSFERASE, E.C.2.5.1.6) IN WHICH MET RESIDUES ARE REPLACED WITH SELENOMETHIONINE RESIDUES (MSE)
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Misaki, S., Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRC
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, COBALT (II) ION, ...
Authors:Takusagawa, F., Kamitori, S., Misaki, S., Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
5ANA
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THE CRYSTAL STRUCTURE OF D(GTACGTAC) AT 2.25 ANGSTROMS RESOLUTION. ARE THE A-DNA'S ALWAYS UNWOUND APPROXIMATELY 10 DEGREES AT THE C-G STEPS
Descriptor:DNA (5'-D(*GP*TP*AP*CP*GP*TP*AP*C)-3'), MAGNESIUM ION
Authors:Takusagawa, F.
Deposit date:1989-10-31
Release date:1990-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structure of d(GTACGTAC) at 2.25 A resolution: are the A-DNA's always unwound approximately 10 degrees at the C-G steps
J.Biomol.Struct.Dyn., 7, 1990
1K0U
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INHIBITION OF S-ADENOSYLHOMOCYSTEINE HYDROLASE BY "ACYCLIC SUGAR" ADENOSINE ANALOGUE D-ERITADENINE
Descriptor:S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, D-ERITADENINE
Authors:Takusagawa, F., Huang, Y., Komoto, J., Takata, Y., Gomi, T., Ogawa, H., Fujioka, M., Powell, D.
Deposit date:2001-09-20
Release date:2001-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
J.Biol.Chem., 277, 2002
1KHH
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CRYSTAL STRUCTURE OF GUANIDINOACETATE METHYLTRANSFERASE FROM RAT LIVER: A TEMPLATE STRUCTURE OF PROTEIN ARGININE METHYLTRANSFERASE
Descriptor:Guanidinoacetate methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Takusagawa, F., Komoto, J.
Deposit date:2001-11-30
Release date:2001-12-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase.
J.Mol.Biol., 320, 2002
1P7L
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S-ADENOSYLMETHIONINE SYNTHETASE COMPLEXED WITH AMPPNP AND MET.
Descriptor:S-adenosylmethionine synthetase, POTASSIUM ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Komoto, J.
Deposit date:2003-05-02
Release date:2004-03-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
2PBJ
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GSH-HEME BOUND MICROSOMAL PROSTAGLANDIN E SYNTHASE
Descriptor:Prostaglandin E synthase 2, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Takusagawa, F., Yamada, T.
Deposit date:2007-03-28
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Biochemistry, 46, 2007
2D55
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STRUCTURAL, PHYSICAL AND BIOLOGICAL CHARACTERISTICS OF RNA.DNA BINDING AGENT N8-ACTINOMYCIN D
Descriptor:DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'), ACTINOMYCIN D
Authors:Shinomiya, M., Chu, W., Carlson, R.G., Weaver, R.F., Takusagawa, F.
Deposit date:1995-05-01
Release date:1995-10-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of the 2:1 Complex between D(Gaagcttc) and the Anticancer Drug Actinomycin D.
J.Mol.Biol., 225, 1992
172D
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MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA
Descriptor:DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3')
Authors:Kamitori, S., Takusagawa, F.
Deposit date:1994-04-18
Release date:1994-10-15
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of d(GAAGCTTC)2-Actinomycin D Complexes and Its Host DNA
J.Am.Chem.Soc., 116, 1994
173D
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MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA
Descriptor:DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'), ACTINOMYCIN D
Authors:Kamitori, S., Takusagawa, F.
Deposit date:1994-04-18
Release date:1994-10-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of D(Gaagcttc)2-Actinomycin D Complexes and its Host DNA
J.Am.Chem.Soc., 116, 1994
1B3R
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RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE
Descriptor:PROTEIN (S-ADENOSYLHOMOCYSTEINE HYDROLASE), NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hu, Y., Komoto, J., Huang, Y., Takusagawa, F., Gomi, T., Ogawa, H., Takata, Y., Fujioka, M.
Deposit date:1998-12-14
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
Biochemistry, 38, 1999
1D2C
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METHYLTRANSFERASE
Descriptor:PROTEIN (GLYCINE N-METHYLTRANSFERASE)
Authors:Huang, Y., Takusagawa, F.
Deposit date:1999-09-23
Release date:1999-10-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
1D2G
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CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE FROM RAT LIVER
Descriptor:GLYCINE N-METHYLTRANSFERASE
Authors:Huang, Y., Komoto, J., Takusagawa, F., Konishi, K., Takata, Y.
Deposit date:1999-10-08
Release date:1999-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
1D2H
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CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLHOMOCYSTEINE
Descriptor:GLYCINE N-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Huang, Y., Komoto, J., Takusagawa, F., Konishi, K., Takata, Y.
Deposit date:1999-10-11
Release date:1999-10-25
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
1D4F
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CRYSTAL STRUCTURE OF RECOMBINANT RAT-LIVER D244E MUTANT S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor:S-ADENOSYLHOMOCYSTEINE HYDROLASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ADENOSINE
Authors:Komoto, J., Huang, Y., Takusagawa, F., Gomi, T., Ogawa, H., Takata, Y., Fujioka, M.
Deposit date:2000-06-22
Release date:2001-01-17
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme.
J.Biol.Chem., 275, 2000
1FUG
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S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE
Authors:Fu, Z., Markham, G.D., Takusagawa, F.
Deposit date:1996-02-25
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Flexible loop in the structure of S-adenosylmethionine synthetase crystallized in the tetragonal modification.
J.Biomol.Struct.Dyn., 13, 1996
1KY4
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S-ADENOSYLHOMOCYSTEINE HYDROLASE REFINED WITH NONCRYSTALLOGRAPHIC RESTRAINTS
Descriptor:S-adenosylhomocysteine hydrolase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Takata, Y., Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine Hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
1KY5
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D244E MUTANT S-ADENOSYLHOMOCYSTEINE HYDROLASE REFINED WITH NONCRYSTALLOGRAPHIC RESTRAINTS
Descriptor:S-adenosylhomocysteine hydrolase, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3'-OXO-ADENOSINE
Authors:Takata, Y., Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
1NBH
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STRUCTURE OF GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE AND ACETATE, GNMT:SAM:ACE
Descriptor:Glycine N-methyltransferase, ACETATE ION, S-ADENOSYLMETHIONINE
Authors:Takata, Y., Takusagawa, F.
Deposit date:2002-12-02
Release date:2003-03-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic mechanism of glycine N-methyltransferase
Biochemistry, 42, 2003
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