Author results

1K0S
  • Download 1k0s
  • View 1k0s
Molmil generated image of 1k0s
SOLUTION STRUCTURE OF THE CHEMOTAXIS PROTEIN CHEW FROM THE THERMOPHILIC ORGANISM THERMOTOGA MARITIMA
Descriptor:CHEMOTAXIS PROTEIN CHEW
Authors:Griswold, I.J., Zhou, H., Swanson, R.V., Simon, M.I., Dahlquist, F.W.
Deposit date:2001-09-20
Release date:2002-02-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure and interactions of CheW from Thermotoga maritima.
Nat.Struct.Biol., 9, 2002
1MP8
  • Download 1mp8
  • View 1mp8
Molmil generated image of 1mp8
CRYSTAL STRUCTURE OF FOCAL ADHESION KINASE (FAK)
Descriptor:focal adhesion kinase 1, ADENOSINE-5'-DIPHOSPHATE
Authors:Nowakowski, J., Cronin, C.N., McRee, D.E., Knuth, M.W., Nelson, C.G., Pavletich, N.P., Rodgers, J., Sang, B.-C., Scheibe, D.N., Swanson, R.V., Thompson, D.A.
Deposit date:2002-09-11
Release date:2003-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
Structure, 10, 2002
1MQ4
  • Download 1mq4
  • View 1mq4
Molmil generated image of 1mq4
CRYSTAL STRUCTURE OF AURORA-A PROTEIN KINASE
Descriptor:AURORA-RELATED KINASE 1, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Nowakowski, J., Cronin, C.N., McRee, D.E., Knuth, M.W., Nelson, C., Pavletich, N.P., Rodgers, J., Sang, B.-C., Scheibe, D.N., Swanson, R.V., Thompson, D.A.
Deposit date:2002-09-13
Release date:2003-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the Cancer-Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography
Structure, 10, 2002
1MQB
  • Download 1mqb
  • View 1mqb
Molmil generated image of 1mqb
CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
Descriptor:Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Nowakowski, J., Cronin, C.N., McRee, D.E., Knuth, M.W., Nelson, C., Pavletich, N., Rogers, J., Sang, B.C., Scheibe, D.N., Swanson, R.V., Thompson, D.A.
Deposit date:2002-09-16
Release date:2003-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Cancer Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography
Structure, 10, 2003
1P31
  • Download 1p31
  • View 1p31
Molmil generated image of 1p31
CRYSTAL STRUCTURE OF UDP-N-ACETYLMURAMIC ACID:L-ALANINE LIGASE (MURC) FROM HAEMOPHILUS INFLUENZAE
Descriptor:UDP-N-acetylmuramate--alanine ligase, MAGNESIUM ION, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID
Authors:Mol, C.D., Brooun, A., Dougan, D.R., Hilgers, M.T., Tari, L.W., Wijnands, R.A., Knuth, M.W., McRee, D.E., Swanson, R.V.
Deposit date:2003-04-16
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae.
J.Bacteriol., 185, 2003
1P3D
  • Download 1p3d
  • View 1p3d
Molmil generated image of 1p3d
CRYSTAL STRUCTURE OF UDP-N-ACETYLMURAMIC ACID:L-ALANINE LIGASE (MURC) IN COMPLEX WITH UMA AND ANP.
Descriptor:UDP-N-acetylmuramate--alanine ligase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE, ...
Authors:Mol, C.D., Brooun, A., Dougan, D.R., Hilgers, M.T., Tari, L.W., Wijnands, R.A., Knuth, M.W., McRee, D.E., Swanson, R.V.
Deposit date:2003-04-17
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae.
J.Bacteriol., 185, 2003
1P74
  • Download 1p74
  • View 1p74
Molmil generated image of 1p74
CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) FROM HAEMOPHILUS INFLUENZAE
Descriptor:Shikimate 5-dehydrogenase
Authors:Ye, S., von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V., McRee, D.E.
Deposit date:2003-04-30
Release date:2003-08-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode
J.Bacteriol., 185, 2003
1P77
  • Download 1p77
  • View 1p77
Molmil generated image of 1p77
CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) FROM HAEMOPHILUS INFLUENZAE
Descriptor:Shikimate 5-dehydrogenase, ACETATE ION, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE
Authors:Ye, S., von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V., McRee, D.E.
Deposit date:2003-04-30
Release date:2003-08-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode
J.Bacteriol., 185, 2003
1QVB
  • Download 1qvb
  • View 1qvb
Molmil generated image of 1qvb
CRYSTAL STRUCTURE OF THE BETA-GLYCOSIDASE FROM THE HYPERTHERMOPHILE THERMOSPHAERA AGGREGANS
Descriptor:BETA-GLYCOSIDASE
Authors:Chi, Y.-I., Martinez-Cruz, L.A., Swanson, R.V., Robertson, D.E., Kim, S.-H.
Deposit date:1999-07-07
Release date:1999-07-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the beta-glycosidase from the hyperthermophile Thermosphaera aggregans: insights into its activity and thermostability.
FEBS Lett., 445, 1999
1RQI
  • Download 1rqi
  • View 1rqi
Molmil generated image of 1rqi
ACTIVE CONFORMATION OF FARNESYL PYROPHOSPHATE SYNTHASE BOUND TO ISOPENTYL PYROPHOSPHATE AND DIMETHYLALLYL S-THIOLODIPHOSPHATE
Descriptor:Geranyltranstransferase, MAGNESIUM ION, DIMETHYLALLYL S-THIOLODIPHOSPHATE, ...
Authors:Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
Deposit date:2003-12-05
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Biol.Chem., 279, 2004
1RQJ
  • Download 1rqj
  • View 1rqj
Molmil generated image of 1rqj
ACTIVE CONFORMATION OF FARNESYL PYROPHOSPHATE SYNTHASE BOUND TO ISOPENTYL PYROPHOSPHATE AND RISEDRONATE
Descriptor:Geranyltranstransferase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
Deposit date:2003-12-05
Release date:2004-03-02
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Biol.Chem., 279, 2004
1RTR
  • Download 1rtr
  • View 1rtr
Molmil generated image of 1rtr
CRYSTAL STRUCTURE OF S. AUREUS FARNESYL PYROPHOSPHATE SYNTHASE
Descriptor:geranyltranstransferase
Authors:Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
Deposit date:2003-12-10
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Mol.Biol., 279, 2004
1T64
  • Download 1t64
  • View 1t64
Molmil generated image of 1t64
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH TRICHOSTATIN A
Descriptor:Histone deacetylase 8, ZINC ION, CALCIUM ION, ...
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T67
  • Download 1t67
  • View 1t67
Molmil generated image of 1t67
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH MS-344
Descriptor:Histone deacetylase 8, ZINC ION, SODIUM ION, ...
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T69
  • Download 1t69
  • View 1t69
Molmil generated image of 1t69
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH SAHA
Descriptor:Histone deacetylase 8, ZINC ION, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1VKG
  • Download 1vkg
  • View 1vkg
Molmil generated image of 1vkg
CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH CRA-19156
Descriptor:Histone deacetylase 8, ZINC ION, SODIUM ION, ...
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-13
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
2NP8
  • Download 2np8
  • View 2np8
Molmil generated image of 2np8
STRUCTURAL BASIS FOR THE INHIBITION OF AURORA A KINASE BY A NOVEL CLASS OF HIGH AFFINITY DISUBSTITUTED PYRIMIDINE INHIBITORS
Descriptor:Serine/threonine-protein kinase 6, SULFATE ION, N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE
Authors:Tari, L.W., Hoffman, I.D., Bensen, D.C., Hunter, M.J., Nix, J., Nelson, K.J., McRee, D.E., Swanson, R.V.
Deposit date:2006-10-26
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
3HF6
  • Download 3hf6
  • View 3hf6
Molmil generated image of 3hf6
CRYSTAL STRUCTURE OF HUMAN TRYPTOPHAN HYDROXYLASE TYPE 1 WITH BOUND LP-521834 AND FE
Descriptor:Tryptophan 5-hydroxylase 1, FE (III) ION, 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine
Authors:Tari, L.W., Swanson, R.V., Hunter, M.J.
Deposit date:2009-05-11
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis
Curr Chem Genomics, 4, 2010
3HF8
  • Download 3hf8
  • View 3hf8
Molmil generated image of 3hf8
CRYSTAL STRUCTURE OF HUMAN TRYOPTOPHAN HYDROXYLASE TYPE 1 WITH BOUND LP-533401 AND FE
Descriptor:Tryptophan 5-hydroxylase 1, FE (III) ION, 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine
Authors:Tari, L.W., Swanson, R.V., Hunter, M.J.
Deposit date:2009-05-11
Release date:2010-04-21
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.
Curr Chem Genomics, 4, 2010
3HFB
  • Download 3hfb
  • View 3hfb
Molmil generated image of 3hfb
CRYSTAL STRUCTURE OF HUMAN TRYOPTOPHAN HYDROXYLASE TYPE 1 WITH LP-534193
Descriptor:Tryptophan 5-hydroxylase 1, FE (III) ION, 4-(5-{[(2'-methylbiphenyl-2-yl)methyl]amino}pyrazin-2-yl)-L-phenylalanine
Authors:Tari, L.W., Swanson, R.V., Hunter, M.J.
Deposit date:2009-05-11
Release date:2010-04-21
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.
Curr Chem Genomics, 4, 2010
3IPX
  • Download 3ipx
  • View 3ipx
Molmil generated image of 3ipx
X-RAY STRUCTURE OF HUMAN DEOXYCYTIDINE KINASE IN COMPLEX WITH ADP AND AN INHIBITOR
Descriptor:Deoxycytidine kinase, ADENOSINE-5'-DIPHOSPHATE, 2'-deoxy-5-fluorocytidine, ...
Authors:Tari, L.W., Swanson, R.V., Hunter, M., Hoffman, I., Stouch, T.R., Carson, K.G.
Deposit date:2009-08-18
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3IPY
  • Download 3ipy
  • View 3ipy
Molmil generated image of 3ipy
X-RAY STRUCTURE OF HUMAN DEOXYCYTIDINE KINASE IN COMPLEX WITH AN INHIBITOR
Descriptor:Deoxycytidine kinase, D-MALATE, 4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine
Authors:Tari, L.W., Swanson, R.V., Hunter, M., Hoffman, I., Stouch, T.R., Carson, K.G.
Deposit date:2009-08-18
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
1TMY
  • Download 1tmy
  • View 1tmy
Molmil generated image of 1tmy
CHEY FROM THERMOTOGA MARITIMA (APO-I)
Descriptor:CHEY PROTEIN
Authors:Usher, K.C., De La Cruz, A., Dahlquist, F.W., Remington, S.J.
Deposit date:1997-05-16
Release date:1997-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability.
Protein Sci., 7, 1998
2TMY
  • Download 2tmy
  • View 2tmy
Molmil generated image of 2tmy
CHEY FROM THERMOTOGA MARITIMA (APO-II)
Descriptor:CHEY PROTEIN
Authors:Usher, K.C., De La Cruz, A., Dahlquist, F.W., Remington, S.J.
Deposit date:1997-05-19
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability.
Protein Sci., 7, 1998
3L5W
  • Download 3l5w
  • View 3l5w
Molmil generated image of 3l5w
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL-13 AND C836 FAB
Descriptor:C836 LIGHT CHAIN, C836 HEAVY CHAIN, Interleukin-13, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2009-12-22
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human framework adaptation of a mouse anti-human IL-13 antibody.
J.Mol.Biol., 398, 2010
<12>