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1S1Q
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BU of 1s1q by Molmil
TSG101(UEV) domain in complex with Ubiquitin
Descriptor: ACETIC ACID, COPPER (II) ION, SULFATE ION, ...
Authors:Sundquist, W.I, Schubert, H.L, Kelly, B.N, Hill, G.C, Holton, J.M, Hill, C.P.
Deposit date:2004-01-07
Release date:2004-05-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ubiquitin recognition by the human TSG101 protein
Mol.Cell, 13, 2004
7S7J
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BU of 7s7j by Molmil
Structure of Human SPASTIN-IST1 complex.
Descriptor: CALCIUM ION, CHLORIDE ION, IST1 homolog, ...
Authors:Skalicky, J.J, Sundquist, W.I.
Deposit date:2021-09-16
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.
Elife, 11, 2022
1XWI
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BU of 1xwi by Molmil
Crystal Structure of VPS4B
Descriptor: SKD1 protein, SULFATE ION
Authors:Scott, A, Sundquist, W.I, Hill, C.P.
Deposit date:2004-11-01
Release date:2005-10-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and mechanistic studies of VPS4 proteins
Embo J., 24, 2005
5KP9
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BU of 5kp9 by Molmil
Structure of Nanoparticle Released from Enveloped Protein Nanoparticle
Descriptor: EPN-01*
Authors:Votteler, J, Ogohara, C, Yi, S, Hsia, Y, Natterman, U, Belnap, D.M, King, N.P, Sundquist, W.I.
Deposit date:2016-07-02
Release date:2016-12-07
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Designed proteins induce the formation of nanocage-containing extracellular vesicles.
Nature, 540, 2016
2XS8
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BU of 2xs8 by Molmil
Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain
Descriptor: PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN, SIVAGMTAN-1 GAG P6
Authors:Zhai, Q, Landesman, M, Robinson, H, Sundquist, W.I, Hill, C.P.
Deposit date:2010-09-24
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1.
J.Virol., 85, 2011
2XS1
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BU of 2xs1 by Molmil
Crystal Structure of ALIX in complex with the SIVmac239 PYKEVTEDL Late Domain
Descriptor: GAG POLYPROTEIN, PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN
Authors:Zhai, Q, Landesman, M, Robinson, H, Sundquist, W.I, Hill, C.P.
Deposit date:2010-09-24
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.296 Å)
Cite:Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1.
J.Virol., 85, 2011
1YXR
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BU of 1yxr by Molmil
NMR Structure of VPS4A MIT Domain
Descriptor: vacuolar protein sorting factor 4A
Authors:Scott, J.A, Gaspar, J, Stuchell, M, Alam, S, Skalicky, J, Sundquist, W.I.
Deposit date:2005-02-22
Release date:2005-09-06
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR Structure of VPS4A MIT Domain
To be Published
5UIE
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BU of 5uie by Molmil
Vps4-Vta1 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DOA4-independent degradation protein 4, ...
Authors:Monroe, N, Shen, P, Han, H, Sundquist, W.I, Hill, C.P.
Deposit date:2017-01-13
Release date:2017-04-12
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase.
Elife, 6, 2017
5V3R
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BU of 5v3r by Molmil
CHMP4C in complex with ALIX BRO1
Descriptor: Charged multivesicular body protein 4c, Programmed cell death 6-interacting protein
Authors:Wenzel, D.M, Alam, S.L, Sundquist, W.I.
Deposit date:2017-03-08
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4WZX
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BU of 4wzx by Molmil
ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins
Descriptor: COBALT (II) ION, IST1 homolog, SULFATE ION, ...
Authors:Caballe, A, Wenzel, D.M, Agromayor, M, Alam, S.L, Skalicky, J.J, Kloc, M, Carlton, J.G, Labrador, L, Sundquist, W.I, Martin-Serrano, J.
Deposit date:2014-11-20
Release date:2015-06-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3859 Å)
Cite:ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.
Elife, 4, 2015
6NDY
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BU of 6ndy by Molmil
Vps4 with Cyclic Peptide Bound in the Central Pore
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ...
Authors:Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P.
Deposit date:2018-12-14
Release date:2019-08-21
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.
Elife, 8, 2019
6OO2
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BU of 6oo2 by Molmil
Vps4 with Cyclic Peptide Bound in the Central Pore
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ...
Authors:Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P.
Deposit date:2019-04-22
Release date:2019-08-21
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.
Elife, 8, 2019
1AUM
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BU of 1aum by Molmil
HIV CAPSID C-TERMINAL DOMAIN (CAC146)
Descriptor: HIV CAPSID
Authors:Hill, C.P, Gamble, T.R, Yoo, S, Vajdos, F.F, Von Schwedler, U.K, Worthylake, D.K, Wang, H, Mccutcheon, J.P, Sundquist, W.I.
Deposit date:1997-08-29
Release date:1998-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
Science, 278, 1997
6PEK
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BU of 6pek by Molmil
Structure of Spastin Hexamer (Subunit A-E) in complex with substrate peptide
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P.
Deposit date:2019-06-20
Release date:2019-12-04
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
6PEN
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BU of 6pen by Molmil
Structure of Spastin Hexamer (whole model) in complex with substrate peptide
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, EYEYEYEYEY, ...
Authors:Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P.
Deposit date:2019-06-20
Release date:2019-12-04
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
5WA1
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BU of 5wa1 by Molmil
CHMP4C A232T in complex with ALIX BRO1
Descriptor: Charged multivesicular body protein 4c, Programmed cell death 6-interacting protein
Authors:Wenzel, D.M, Alam, S.L, Sundquist, W.I.
Deposit date:2017-06-24
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.868 Å)
Cite:A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AP1
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BU of 6ap1 by Molmil
Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p
Descriptor: ACE-ASP-GLU-ILE-VAL-ASN-LYS-VAL-LEU-NH2, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Han, H, Monroe, N, Shen, P, Sundquist, W.I, Hill, C.P.
Deposit date:2017-08-16
Release date:2017-12-06
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
Elife, 6, 2017
6BMF
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BU of 6bmf by Molmil
Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Han, H, Monroe, N, Shen, P, Sundquist, W.I, Hill, C.P.
Deposit date:2017-11-14
Release date:2017-12-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
Elife, 6, 2017
1Q5W
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BU of 1q5w by Molmil
Ubiquitin Recognition by Npl4 Zinc-Fingers
Descriptor: Ubiquitin, ZINC ION, homolog of yeast nuclear protein localization 4
Authors:Alam, S.L, Sun, J, Payne, M, Welch, B.D, Blake, B.K, Davis, D.R, Meyer, H.H, Emr, S.D, Sundquist, W.I.
Deposit date:2003-08-11
Release date:2004-03-30
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Ubiquitin interactions of NZF zinc fingers.
Embo J., 23, 2004
3ZXP
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BU of 3zxp by Molmil
Structural and Functional Analyses of the Bro1 Domain Protein BROX
Descriptor: BRO1 DOMAIN-CONTAINING PROTEIN BROX
Authors:Zhai, Q, Landesman, M.B, Sundquist, W.I, Hill, C.P.
Deposit date:2011-08-13
Release date:2011-11-16
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structure of the Bro1 Domain Protein Brox and Functional Analyses of the Alix Bro1 Domain in HIV-1 Budding.
Plos One, 6, 2011
1GWP
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BU of 1gwp by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE MATURE HIV-1 CAPSID PROTEIN
Descriptor: GAG POLYPROTEIN
Authors:Tang, C, Gitti, R.K, Lee, B.M, Walker, J, Summers, M.F, Yoo, S, Sundquist, W.I.
Deposit date:2002-03-22
Release date:2002-06-21
Last modified:2014-03-12
Method:SOLUTION NMR
Cite:Structure of the N-Terminal 283-Residue Fragment of the Immature HIV-1 Gag Polyprotein
Nat.Struct.Biol., 9, 2002
1NJ3
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BU of 1nj3 by Molmil
Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4
Descriptor: NPL4, ZINC ION
Authors:Wang, B, Alam, S.L, Meyer, H.H, Payne, M, Stemmler, T.L, Davis, D.R, Sundquist, W.I.
Deposit date:2002-12-30
Release date:2003-04-22
Last modified:2017-11-22
Method:SOLUTION NMR
Cite:Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4.
J.Biol.Chem., 278, 2003
1O06
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BU of 1o06 by Molmil
Crystal structure of the Vps27p Ubiquitin Interacting Motif (UIM)
Descriptor: Vacuolar protein sorting-associated protein VPS27, ZINC ION
Authors:Fisher, R.D, Wang, B, Alam, S.L, Higginson, D.S, Rich, R, Myszka, D, Sundquist, W.I, Hill, C.P.
Deposit date:2003-02-20
Release date:2003-07-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure and ubiquitin binding of the ubiquitin-interacting motif.
J.Biol.Chem., 278, 2003
3C3Q
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BU of 3c3q by Molmil
ALIX Bro1-domain:CHMIP4B co-crystal structure
Descriptor: Charged multivesicular body protein 4b peptide, GLYCEROL, Programmed cell death 6-interacting protein
Authors:McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P.
Deposit date:2008-01-28
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3C3O
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BU of 3c3o by Molmil
ALIX Bro1-domain:CHMIP4A co-crystal structure
Descriptor: Charged multivesicular body protein 4a peptide, GLYCEROL, Programmed cell death 6-interacting protein
Authors:McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P.
Deposit date:2008-01-28
Release date:2008-06-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008

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