1S1Q
 
 | | TSG101(UEV) domain in complex with Ubiquitin | | Descriptor: | ACETIC ACID, COPPER (II) ION, SULFATE ION, ... | | Authors: | Sundquist, W.I, Schubert, H.L, Kelly, B.N, Hill, G.C, Holton, J.M, Hill, C.P. | | Deposit date: | 2004-01-07 | | Release date: | 2004-05-04 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Ubiquitin recognition by the human TSG101 protein
Mol.Cell, 13, 2004
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7S7J
 | | Structure of Human SPASTIN-IST1 complex. | | Descriptor: | CALCIUM ION, CHLORIDE ION, IST1 homolog, ... | | Authors: | Skalicky, J.J, Sundquist, W.I. | | Deposit date: | 2021-09-16 | | Release date: | 2022-09-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.
Elife, 11, 2022
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4WZX
 | | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins | | Descriptor: | COBALT (II) ION, IST1 homolog, SULFATE ION, ... | | Authors: | Caballe, A, Wenzel, D.M, Agromayor, M, Alam, S.L, Skalicky, J.J, Kloc, M, Carlton, J.G, Labrador, L, Sundquist, W.I, Martin-Serrano, J. | | Deposit date: | 2014-11-20 | | Release date: | 2015-06-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.3859 Å) | | Cite: | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.
Elife, 4, 2015
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3ZXP
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6AP1
 | | Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p | | Descriptor: | ACE-ASP-GLU-ILE-VAL-ASN-LYS-VAL-LEU-NH2, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Han, H, Monroe, N, Shen, P, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2017-08-16 | | Release date: | 2017-12-06 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
Elife, 6, 2017
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6BMF
 | | Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Han, H, Monroe, N, Shen, P, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2017-11-14 | | Release date: | 2017-12-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
Elife, 6, 2017
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1XWI
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1YXR
 | | NMR Structure of VPS4A MIT Domain | | Descriptor: | vacuolar protein sorting factor 4A | | Authors: | Scott, J.A, Gaspar, J, Stuchell, M, Alam, S, Skalicky, J, Sundquist, W.I. | | Deposit date: | 2005-02-22 | | Release date: | 2005-09-06 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | NMR Structure of VPS4A MIT Domain
To be Published
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2XS8
 | | Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain | | Descriptor: | PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN, SIVAGMTAN-1 GAG P6 | | Authors: | Zhai, Q, Landesman, M, Robinson, H, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2010-09-24 | | Release date: | 2010-11-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.498 Å) | | Cite: | Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1.
J.Virol., 85, 2011
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2XS1
 | | Crystal Structure of ALIX in complex with the SIVmac239 PYKEVTEDL Late Domain | | Descriptor: | GAG POLYPROTEIN, PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN | | Authors: | Zhai, Q, Landesman, M, Robinson, H, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2010-09-24 | | Release date: | 2010-11-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.296 Å) | | Cite: | Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1.
J.Virol., 85, 2011
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1Q5W
 | | Ubiquitin Recognition by Npl4 Zinc-Fingers | | Descriptor: | Ubiquitin, ZINC ION, homolog of yeast nuclear protein localization 4 | | Authors: | Alam, S.L, Sun, J, Payne, M, Welch, B.D, Blake, B.K, Davis, D.R, Meyer, H.H, Emr, S.D, Sundquist, W.I. | | Deposit date: | 2003-08-11 | | Release date: | 2004-03-30 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Ubiquitin interactions of NZF zinc fingers.
Embo J., 23, 2004
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5KP9
 | | Structure of Nanoparticle Released from Enveloped Protein Nanoparticle | | Descriptor: | EPN-01* | | Authors: | Votteler, J, Ogohara, C, Yi, S, Hsia, Y, Natterman, U, Belnap, D.M, King, N.P, Sundquist, W.I. | | Deposit date: | 2016-07-02 | | Release date: | 2016-12-07 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | Designed proteins induce the formation of nanocage-containing extracellular vesicles.
Nature, 540, 2016
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3JC1
 | | Electron cryo-microscopy of the IST1-CHMP1B ESCRT-III copolymer | | Descriptor: | Charged multivesicular body protein 1b, Increased Sodium Tolerance 1 (IST1) | | Authors: | McCullough, J, Clippinger, A.K, Talledge, N, Skowyra, M.L, Saunders, M.G, Naismith, T.V, Colf, L.A, Afonine, P, Arthur, C, Sundquist, W.I, Hanson, P.I, Frost, A. | | Deposit date: | 2015-11-09 | | Release date: | 2015-12-16 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure and membrane remodeling activity of ESCRT-III helical polymers.
Science, 350, 2015
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5UIE
 | | Vps4-Vta1 complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DOA4-independent degradation protein 4, ... | | Authors: | Monroe, N, Shen, P, Han, H, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2017-01-13 | | Release date: | 2017-04-12 | | Last modified: | 2020-01-01 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase.
Elife, 6, 2017
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5V3R
 | | CHMP4C in complex with ALIX BRO1 | | Descriptor: | Charged multivesicular body protein 4c, Programmed cell death 6-interacting protein | | Authors: | Wenzel, D.M, Alam, S.L, Sundquist, W.I. | | Deposit date: | 2017-03-08 | | Release date: | 2018-09-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.906 Å) | | Cite: | A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5WA1
 | | CHMP4C A232T in complex with ALIX BRO1 | | Descriptor: | Charged multivesicular body protein 4c, Programmed cell death 6-interacting protein | | Authors: | Wenzel, D.M, Alam, S.L, Sundquist, W.I. | | Deposit date: | 2017-06-24 | | Release date: | 2018-09-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.868 Å) | | Cite: | A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6NDY
 | | Vps4 with Cyclic Peptide Bound in the Central Pore | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ... | | Authors: | Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P. | | Deposit date: | 2018-12-14 | | Release date: | 2019-08-21 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.
Elife, 8, 2019
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6OO2
 | | Vps4 with Cyclic Peptide Bound in the Central Pore | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ... | | Authors: | Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P. | | Deposit date: | 2019-04-22 | | Release date: | 2019-08-21 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.
Elife, 8, 2019
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6PEK
 | | Structure of Spastin Hexamer (Subunit A-E) in complex with substrate peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2019-06-20 | | Release date: | 2019-12-04 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
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6PEN
 | | Structure of Spastin Hexamer (whole model) in complex with substrate peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, EYEYEYEYEY, ... | | Authors: | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2019-06-20 | | Release date: | 2019-12-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
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1O06
 | | Crystal structure of the Vps27p Ubiquitin Interacting Motif (UIM) | | Descriptor: | Vacuolar protein sorting-associated protein VPS27, ZINC ION | | Authors: | Fisher, R.D, Wang, B, Alam, S.L, Higginson, D.S, Rich, R, Myszka, D, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2003-02-20 | | Release date: | 2003-07-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structure and ubiquitin binding of the ubiquitin-interacting motif.
J.Biol.Chem., 278, 2003
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7LP5
 | | Structure of Nedd4L WW3 domain | | Descriptor: | Angiomotin,E3 ubiquitin-protein ligase NEDD4-like | | Authors: | Alam, S.L, Alian, A, Thompson, T, Rheinemann, L, Volkman, B.F, Peterson, F.C, Sundquist, W.I. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2021-08-25 | | Method: | SOLUTION NMR | | Cite: | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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7LP1
 | | Structure of Nedd4L WW3 domain | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, GLYCEROL, NITRATE ION | | Authors: | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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7LP3
 | | Structure of Nedd4L WW3 domain | | Descriptor: | Angiomotin, E3 ubiquitin-protein ligase NEDD4-like, SULFATE ION | | Authors: | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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7LP2
 | | Structure of Nedd4L WW3 domain | | Descriptor: | Angiomotin, E3 ubiquitin-protein ligase, GLYCEROL, ... | | Authors: | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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