Author results

4FLN
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CRYSTAL STRUCTURE OF PLANT PROTEASE DEG2
Descriptor:Protease Do-like 2, chloroplastic, Unknown peptide
Authors:Gong, W., Liu, L., Sun, R., Gao, F.
Deposit date:2012-06-15
Release date:2012-09-19
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Arabidopsis deg2 protein reveals an internal PDZ ligand locking the hexameric resting state.
J.Biol.Chem., 287, 2012
6DCG
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DISCOVERY OF MK-8353: AN ORALLY BIOAVAILABLE DUAL MECHANISM ERK INHIBITOR FOR ONCOLOGY
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Authors:Boga, S.B., Deng, Y., Zhu, L., Nan, Y., Cooper, A., Shipps Jr., G.W., Doll, R., Shih, N., Zhu, H., Sun, R., Wang, T., Paliwal, S., Tsui, H., Gao, X., Yao, X., Desai, J., Wang, J., Alhassan, A.B., Kelly, J., Patel, M., Muppalla, K., Gudipati, S., Zhang, L., Buevich, A., Hesk, D., Carr, D., Dayananth, P., Mei, H., Cox, K., Sherborne, B., Hruza, A.W., Xiao, L., Jin, W., Long, B., Liu, G., Taylor, S.A., Kirschmeier, P., Windsor, W.T., Bishop, R., Samatar, A.A.
Deposit date:2018-05-06
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
1ZXT
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CRYSTAL STRUCTURE OF A VIRAL CHEMOKINE
Descriptor:functional macrophage inflammatory protein 1-alpha homolog
Authors:Luz, J.G., Yu, M., Su, Y., Wu, Z., Zhou, Z., Sun, R., Wilson, I.A.
Deposit date:2005-06-08
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.
J.Mol.Biol., 352, 2005
5M00
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CRYSTAL STRUCTURE OF MURINE P14 TCR COMPLEX WITH H-2DB AND Y4A, MODIFIED GP33 PEPTIDE FROM LCMV
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Achour, A., Sandalova, T., Sun, R., Han, X.
Deposit date:2016-10-03
Release date:2017-12-20
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Thernary complexes of TCR P14 give insights into the mechanisms behind reestablishment of CTL responses against a viral escape mutant
To Be Published
5M01
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CRYSTAL STRUCTURE OF MURINE P14 TCR/ H-2DB COMPLEX WITH PA, MODIFIED GP33 PEPTIDE FROM LCMV
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Achour, A., Sandalova, T., Sun, R., Han, X.
Deposit date:2016-10-03
Release date:2017-10-25
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Thernary complexes of TCR P14 give insights into the mechanisms behind reestablishment of CTL responses against a viral escape mutant
To Be Published
5M02
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CRYSTAL STRUCTURE OF MURINE P14 TCR / H-2DB WITH PF, MODIFIED GP33 PEPTIDE FROM LCMV
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Achour, A., Sandalova, T., Sun, R.
Deposit date:2016-10-03
Release date:2017-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Thernary complexes of TCR P14 give insights into the mechanisms behind reestablishment of CTL responses against a viral escape mutant
To Be Published
5TC1
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IN SITU STRUCTURES OF THE GENOME AND GENOME-DELIVERY APPARATUS IN SSRNA BACTERIOPHAGE MS2
Descriptor:Capsid protein, Maturation protein, phage MS2 genome
Authors:Dai, X.H., Li, Z.H., Lai, M., Shu, S., Du, Y.S., Zhou, Z.H., Sun, R.
Deposit date:2016-09-13
Release date:2016-12-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus.
Nature, 541, 2017
5UFW
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ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH OP1154
Descriptor:Estrogen receptor, (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol
Authors:Fanning, S.W., Hodges-Gallagher, L., Myles, D.C., Sun, R., Fowler, C.E., Green, B.D., Harmon, C.L., Greene, G.L., Kushner, P.J.
Deposit date:2017-01-06
Release date:2018-01-10
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.583 Å)
Cite:Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Nat Commun, 9, 2018
5UFX
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ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH OP1074
Descriptor:Estrogen receptor, (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol
Authors:Fanning, S.W., Hodges-Gallagher, L., Myles, D.C., Sun, R., Fowler, C.E., Green, B.D., Harmon, C.L., Greene, G.L., Kushner, P.J.
Deposit date:2017-01-06
Release date:2018-01-10
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.5503 Å)
Cite:Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Nat Commun, 9, 2018
6B1T
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IMPROVED CRYOEM STRUCTURE OF HUMAN ADENOVIRUS TYPE 5 WITH ATOMIC DETAILS OF MINOR PROTEINS VI AND VII
Descriptor:Hexon protein, Penton protein, Pre-hexon-linking protein IIIa, ...
Authors:Dai, X.H., Wu, L., Sun, R., Zhou, Z.H.
Deposit date:2017-09-18
Release date:2017-09-27
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Atomic Structures of Minor Proteins VI and VII in Human Adenovirus.
J. Virol., 91, 2017
6B43
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CRYOEM STRUCTURE AND ATOMIC MODEL OF THE KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS CAPSID
Descriptor:Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ...
Authors:Dai, X.H., Gong, D.Y., Sun, R., Zhou, Z.H.
Deposit date:2017-09-25
Release date:2017-11-08
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication.
Nature, 553, 2018
6C42
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ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH OP1156
Descriptor:Estrogen receptor, (2R,3S,4R)-3-(4-hydroxyphenyl)-4-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol
Authors:Fanning, S.W., Hodges-Gallager, L., Myles, D.C., Sun, R., Fowler, C.E., Green, B.D., Harmon, C.L., Greene, G.L., Kushner, P.J.
Deposit date:2018-01-11
Release date:2018-02-14
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Nat Commun, 9, 2018
6EWJ
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PUTATIVE SUGAR AMINOTRANSFERASE SPR1654 FROM STREPTOCOCCUS PNEUMONIAE, APO-FORM
Descriptor:Putative capsular polysaccharide biosynthesis protein
Authors:Achour, A., Sun, R., Sandalova, T., Han, X.
Deposit date:2017-11-04
Release date:2018-05-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis inStreptococcus pneumoniae.
Open Biol, 8, 2018
6EWQ
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PUTATIVE SUGAR AMINOTRANSFERASE SPR1654 FROM STREPTOCOCCUS PNEUMONIAE, PLP-FORM
Descriptor:Putative capsular polysaccharide biosynthesis protein, PYRIDOXAL-5'-PHOSPHATE
Authors:Achour, A., Sun, R., Sandalova, T., Han, X.
Deposit date:2017-11-06
Release date:2018-05-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis inStreptococcus pneumoniae.
Open Biol, 8, 2018
6EWR
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PUTATIVE SUGAR AMINOTRANSFERASE SPR1654 FROM STREPTOCOCCUS PNEUMONIAE, PMP-FORM
Descriptor:Putative capsular polysaccharide biosynthesis protein, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE
Authors:Achour, A., Sun, R., Sandalova, T., Han, X.
Deposit date:2017-11-06
Release date:2018-05-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis inStreptococcus pneumoniae.
Open Biol, 8, 2018
6G7B
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NT2 DOMAIN OF THE TSSA COMPONENT FROM THE TYPE VI SECRETION SYSTEM OF AEROMONAS HYDROPHILA.
Descriptor:ImpA-related domain protein
Authors:Dix, S.D., Owen, H.J., Sun, R., Ahmad, A., Shastri, S., Spiewak, H.L., Mosby, D.J., Harris, M.J., Batters, S.L., Tzokov, S.B., Sedelnikova, S.E., Baker, P.J., Bullough, P.A., Rice, D.W., Thomas, M.S.
Deposit date:2018-04-05
Release date:2018-11-21
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural insights into the function of type VI secretion system TssA subunits.
Nat Commun, 9, 2018
6G7C
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NT2-CTD DOMAINS OF THE TSSA COMPONENT FROM THE TYPE VI SECRETION SYSTEM OF AEROMONAS HYDROPHILA.
Descriptor:ImpA-related domain protein
Authors:Dix, S.D., Owen, H.J., Sun, R., Ahmad, A., Shastri, S., Spiewak, H.L., Mosby, D.J., Harris, M.J., Batters, S.L., Tzokov, S.B., Sedelnikova, S.E., Baker, P.J., Bullough, P.A., Rice, D.W., Thomas, M.S.
Deposit date:2018-04-05
Release date:2018-11-21
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Structural insights into the function of type VI secretion system TssA subunits.
Nat Commun, 9, 2018
6H8E
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TRUNCATED DERIVATIVE OF THE C-TERMINAL DOMAIN OF THE TSSA COMPONENT OF THE TYPE VI SECRETION SYSTEM FROM BURKHOLDERIA CENOCEPACIA
Descriptor:Type VI secretion protein ImpA
Authors:Dix, S.R., Owen, H.J., Sun, R., Ahmad, A., Shastri, S., Spiewak, H.L., Mosby, D.J., Harris, M.J., Batters, S.L., Brooker, T.A., Tzokov, S.B., Sedelnikova, S.E., Baker, P.J., Bullough, P.A., Rice, D.W., Thomas, M.S.
Deposit date:2018-08-02
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insights into the function of type VI secretion system TssA subunits.
Nat Commun, 9, 2018
6H8F
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FRAGMENT OF THE C-TERMINAL DOMAIN OF THE TSSA COMPONENT OF THE TYPE VI SECRETION SYSTEM FROM BURKHOLDERIA CENOCEPACIA
Descriptor:TssA
Authors:Dix, S.R., Owen, H.J., Sun, R., Ahmad, A., Shastri, S., Spiewak, H.L., Mosby, D.J., Harris, M.J., Batters, S.L., Brooker, T.A., Tzokov, S.B., Sedelnikova, S.E., Baker, P.J., Bullough, P.A., Rice, D.W., Thomas, M.S.
Deposit date:2018-08-02
Release date:2018-11-21
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural insights into the function of type VI secretion system TssA subunits.
Nat Commun, 9, 2018
6HS5
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N-TERMINAL DOMAIN INCLUDING THE CONSERVED IMPA_N REGION OF THE TSSA COMPONENT OF THE TYPE VI SECRETION SYSTEM FROM BURKHOLDERIA CENOCEPACIA
Descriptor:TssA, CALCIUM ION, 1,2-ETHANEDIOL
Authors:Dix, S.R., Owen, H.J., Sun, R., Ahmad, A., Shastri, S., Spiewak, H.L., Mosby, D.J., Harris, M.J., Batters, S.L., Brooker, T.A., Tzokov, S.B., Sedelnikova, S.E., Baker, P.J., Bullough, P.A., Rice, D.W., Thomas, M.S.
Deposit date:2018-09-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into the function of type VI secretion system TssA subunits.
Nat Commun, 9, 2018
6HS6
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C-TERMINAL DOMAIN OF THE TSSA COMPONENT OF THE TYPE VI SECRETION SYSTEM FROM BURKHOLDERIA CENOCEPACIA
Descriptor:Type VI secretion protein ImpA
Authors:Dix, S.R., Owen, H.J., Sun, R., Ahmad, A., Shastri, S., Spiewak, H.L., Mosby, D.J., Harris, M.J., Batters, S.L., Brooker, T.A., Tzokov, S.B., Sedelnikova, S.E., Baker, P.J., Bullough, P.A., Rice, D.W., Thomas, M.S.
Deposit date:2018-09-28
Release date:2018-11-21
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Structural insights into the function of type VI secretion system TssA subunits.
Nat Commun, 9, 2018
4IC5
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CRYSTAL STRUCTURE OF DEG5
Descriptor:Protease Do-like 5, chloroplastic, CALCIUM ION
Authors:Gong, W., Sun, W., Fan, H., Gao, F., Liu, L.
Deposit date:2012-12-10
Release date:2013-05-01
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.607 Å)
Cite:The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases
Acta Crystallogr.,Sect.D, 69, 2013
4IC6
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CRYSTAL STRUCTURE OF DEG8
Descriptor:Protease Do-like 8, chloroplastic
Authors:Gong, W., Sun, W., Fan, H., Gao, F., Liu, L.
Deposit date:2012-12-10
Release date:2013-05-01
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases
Acta Crystallogr.,Sect.D, 69, 2013
1M5B
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X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-ME-TET-AMPA AT 1.85 A RESOLUTION.
Descriptor:Glutamate receptor 2, ZINC ION, (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID
Authors:Hogner, A., Kastrup, J.S., Jin, R., Liljefors, T., Mayer, M.L., Egebjerg, J., Larsen, I.K., Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
2OA5
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CRYSTAL STRUCTURE OF ORF52 FROM MURID HERPESVIRUS (MUHV-4) (MURINE GAMMAHERPESVIRUS 68) AT 2.1 A RESOLUTION. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MHR28B.
Descriptor:Hypothetical protein BQLF2, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL
Authors:Benach, J., Chen, Y., Seetharaman, J., Janjua, H., Xiao, R., Cunningham, K., Ma, L.-C., Ho, C.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-12-14
Release date:2007-01-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68.
J.Biol.Chem., 282, 2007
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