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2I7K
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SOLUTION STRUCTURE OF THE BROMODOMAIN OF HUMAN BRD7 PROTEIN
Descriptor:Bromodomain-containing protein 7
Authors:Sun, H., Liu, J., Zhang, J., Huang, H., Wu, J., Shi, Y.
Deposit date:2006-08-31
Release date:2007-07-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4
Biochem.Biophys.Res.Commun., 358, 2007
2DK9
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SOLUTION STRUCTURE OF CALPONIN HOMOLOGY DOMAIN OF HUMAN MICAL-1
Descriptor:NEDD9-interacting protein with calponin homology and LIM domains
Authors:Sun, H., Dai, H., Zhang, J., Xiong, S., Wu, J., Shi, Y.
Deposit date:2006-04-07
Release date:2006-09-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of calponin homology domain of Human MICAL-1
J.Biomol.Nmr, 36, 2006
5WTD
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STRUCTURE OF HUMAN SERUM TRANSFERRIN BOUND RUTHENIUM AT N-LOBE
Descriptor:Serotransferrin, FE (III) ION, MALONATE ION, ...
Authors:Sun, H., Wang, M., Lai, T.P., Zhang, H., Hao, Q.
Deposit date:2016-12-11
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Ruthenium bound to the N-lobe of human serum transferrin
To Be Published
5X5P
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HUMAN SERUM TRANSFERRIN BOUND TO RUTHENIUM NTA
Descriptor:Serotransferrin, MALONATE ION, FE (III) ION, ...
Authors:Sun, H., Wang, M.
Deposit date:2017-02-17
Release date:2018-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The additional metal-binding site on human serum transferrin surface
To Be Published
2XFL
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INDUCED-FIT AND ALLOSTERIC EFFECTS UPON POLYENE BINDING REVEALED BY CRYSTAL STRUCTURES OF THE DYNEMICIN THIOESTERASE
Descriptor:DYNE7
Authors:Liew, C.W., Sharff, A., Kotaka, M., Kong, R., Sun, H., Bricogne, G., Liang, Z., Lescar, J.
Deposit date:2010-05-26
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Induced-Fit Upon Ligand Binding Revealed by Crystal Structures of the Hot-Dog Fold Thioesterase in Dynemicin Biosynthesis.
J.Mol.Biol., 404, 2010
5XP6
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NATIVE STRUCTURE OF NDM-1 CRYSTALLIZED AT PH5.5
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, HYDROXIDE ION, ...
Authors:Zhang, H., Ma, G., Lai, J., Sun, H.
Deposit date:2017-06-01
Release date:2018-03-07
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors
Nat Commun, 9, 2018
5XP9
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CRYSTAL STRUCTURE OF BISMUTH BOUND NDM-1
Descriptor:Metallo-beta-lactamase type 2, Bismuth(III) ION, GLYCEROL
Authors:Zhang, H., Ma, G., Lai, T.P., Sun, H.
Deposit date:2017-06-01
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors
Nat Commun, 9, 2018
6BNS
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STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC CO-ACTIVATOR PEPTIDE AND COMPOUND 25A AKA BICYCLIC HEXAFLUOROISOPROPYL 2 ALCOHOL SULFONAMIDES
Descriptor:Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 Chimera, 2-[(2S)-4-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide
Authors:DHAR, T.G., GONG, H., WEINSTEIN, D.S., LU, Z., DUAN, J.J.W., STACHURA, S., HAQUE, L., KARMAKAR, A., HEMAGIRI, H., RAUT, D.K., GUPTA, A.K., KHAN, J.A., SACK, J.S., CAMAC, D.M., PUDZIANOWSKI, A.A., WU, D.R., YARDE, M., SHEN, D.R., BOROWSKI, V., XIE, J.H., SUN, H., ARIENZO, C.D., DABROS, M., GALELLA, M.A., WANG, F., WEIGELT, C.A., ZHAO, Q., FOSTER, W., SOMERVILLE, J.E., SALTER-CID, L.M., BARRISH, J.C., CARTER, P.H.
Deposit date:2017-11-17
Release date:2017-12-20
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (ROR gamma /RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg. Med. Chem. Lett., 28, 2018
2KR7
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SOLUTION STRUCTURE OF HELICOBACTER PYLORI SLYD
Descriptor:FKBP-type peptidyl-prolyl cis-trans isomerase slyD
Authors:Cheng, T., Li, H., Xia, W., Sze, K., Sun, H.
Deposit date:2009-12-07
Release date:2010-12-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:solution structure of Helicobacter pylori SlyD
To be Published
3QYT
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DIFERRIC BOUND HUMAN SERUM TRANSFERRIN
Descriptor:Serotransferrin, FE (III) ION, CARBONATE ION, ...
Authors:Yang, N., Zhang, H., Wang, M., Hao, Q., Sun, H.
Deposit date:2011-03-03
Release date:2012-03-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe
Sci Rep, 2, 2012
4DZO
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STRUCTURE OF HUMAN MAD1 C-TERMINAL DOMAIN REVEALS ITS INVOLVEMENT IN KINETOCHORE TARGETING
Descriptor:Mitotic spindle assembly checkpoint protein MAD1
Authors:Luo, X., Sun, H., Tomchick, D.R.
Deposit date:2012-03-01
Release date:2012-04-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting.
Proc.Natl.Acad.Sci.USA, 109, 2012
4H0W
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BISMUTH BOUND HUMAN SERUM TRANSFERRIN
Descriptor:Serotransferrin, FE (III) ION, CARBONATE ION, ...
Authors:Yang, N., Zhang, H., Wang, M., Hao, Q., Sun, H.
Deposit date:2012-09-10
Release date:2012-12-26
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe.
Sci Rep, 2, 2012
4X1B
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HUMAN SERUM TRANSFERRIN WITH FERRIC ION BOUND AT THE C-LOBE ONLY
Descriptor:Serotransferrin, FE (III) ION, MALONATE ION, ...
Authors:Wang, M., Zhang, H., Sun, H.
Deposit date:2014-11-24
Release date:2015-04-08
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:"Anion clamp" allows flexible protein to impose coordination geometry on metal ions
Chem.Commun.(Camb.), 51, 2015
4X1D
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YTTERBIUM-BOUND HUMAN SERUM TRANSFERRIN
Descriptor:Serotransferrin, YTTERBIUM (III) ION, MALONATE ION, ...
Authors:Wang, M., Zhang, H., Sun, H.
Deposit date:2014-11-24
Release date:2015-04-08
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:"Anion clamp" allows flexible protein to impose coordination geometry on metal ions
Chem.Commun.(Camb.), 51, 2015
5Y6K
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HUMAN SERUM TRNASFERRIN BOUND TO A FLUORESCENT PROBE
Descriptor:Serotransferrin, MALONATE ION, FE (III) ION, ...
Authors:Jiang, N., Cheng, T., Wang, M., Chan, G.C.F., Jin, L., Li, H., Sun, H.
Deposit date:2017-08-12
Release date:2018-01-24
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Tracking iron-associated proteomes in pathogens by a fluorescence approach.
Metallomics, 10, 2018
5Z3W
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MALATE DEHYDROGENASE BINDS SILVER AT C113
Descriptor:Malate dehydrogenase, SILVER ION
Authors:Wang, H., Wang, M., Sun, H.
Deposit date:2018-01-09
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of silver-bound malate dehydrogenase
To Be Published
5X5S
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LIGAND INDUCED STRUCTURE OF AMYP-SBD
Descriptor:Amylase
Authors:Li, X., Yu, J., Sun, H., Zhang, X.
Deposit date:2017-02-17
Release date:2017-04-05
Method:SOLUTION NMR
Cite:Ligand binding induced folding of a novel CBM69 starch binding domain
To Be Published
1QHI
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HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
Descriptor:PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
Authors:Bennett, M.S., Wien, F., Champness, J.N., Batuwangala, T., Rutherford, T., Summers, W.C., Sun, H., Wright, G., Sanderson, M.R.
Deposit date:1999-05-12
Release date:1999-07-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
FEBS Lett., 443, 1999
2KI5
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HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION
Descriptor:PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-HYROXYETHOXYMETHYLGUANINE
Authors:Bennett, M.S., Wien, F., Champness, J.N., Batuwangala, T., Rutherford, T., Summers, W.C., Sun, H., Wright, G., Sanderson, M.R.
Deposit date:1999-02-12
Release date:1999-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
FEBS Lett., 443, 1999
2W3X
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CRYSTAL STRUCTURE OF A BIFUNCTIONAL HOTDOG FOLD THIOESTERASE IN ENEDIYNE BIOSYNTHESIS, CALE7
Descriptor:CALE7, PHOSPHATE ION, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), ...
Authors:Kotaka, M., Kong, R., Qureshi, I., Ho, Q.S., Sun, H., Liew, C.W., Goh, L.P., Cheung, P., Mu, Y., Lescar, J., Liang, Z.X.
Deposit date:2008-11-17
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and Catalytic Mechanism of the Thioesterase Cale7 in Enediyne Biosynthesis.
J.Biol.Chem., 284, 2009
3S49
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RNA CRYSTAL STRUCTURE WITH 2-SE-URIDINE MODIFICATION
Descriptor:RNA (5'-R(*GP*UP*AP*UP*AP*(RUS)P*AP*C)-3'), POTASSIUM ION
Authors:Sheng, J., Gan, J., Sun, H., Hassan, A.E.H., Jiang, S., Huang, Z.
Deposit date:2011-05-19
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Higher Specificity of RNA Base Pairing with 2-Selenouridine
To be Published
4JAB
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U/G WOBBLE BASE PAIR IN A RNA DUPLEX
Descriptor:RNA (5'-R(*GP*UP*GP*UP*AP*UP*AP*C)-3'), STRONTIUM ION
Authors:Jiang, S., Sun, H., Gan, J., Huang, Z.
Deposit date:2013-02-18
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:2-Se Uridine enhanced U/G Wobble Base Pair Discrimination
To be Published
4JAH
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CRYSTAL STRUCTURE OF 2-SELENOURIDINE CONTAINING RNA
Descriptor:RNA (5'-R(*GP*UP*GP*UP*AP*(RUS)P*AP*C)-3'), POTASSIUM ION
Authors:Jiang, S., Gan, J., Sun, H., Huang, Z.
Deposit date:2013-02-18
Release date:2014-01-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of 2-Selenouridine containing RNA
To be Published
4KW0
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STRUCTURE OF DICKERSON-DREW DODECAMER WITH 2'-MESE-ARA-G MODIFICATION
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*(1TW)P*CP*G)-3'), MAGNESIUM ION
Authors:Jiang, S., Gan, J., Sheng, J., Sun, H., Huang, Z.
Deposit date:2013-05-23
Release date:2013-07-17
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-G modification
TO BE PUBLISHED
4O0I
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CRYSTAL STRUCTURE OF FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS WITH 2'-MESE-ARABINO-GUANOSINE DERIVATIZED DNA
Descriptor:DNA polymerase I, 5'-D(*C*(1TW)P*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', SULFATE ION, ...
Authors:Jiang, S., Gan, J., Sun, H., Huang, Z.
Deposit date:2013-12-13
Release date:2014-12-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with 2'-MeSe-arabino-guanosine derivatized DNA
TO BE PUBLISHED