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1MTS
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, (+)-2-[4-[(-1-ACETIMIDOYL-4-PIPERIDINYL)OXY]-3-(7-AMIDINO-2-NAPHTHYL)PROPIONIC ACID
Authors:Stubbs, M.T.
Deposit date:1997-05-16
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
FEBS Lett., 375, 1995
1MTU
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, (+)-2-[4-[(-1-ACETIMIDOYL-4-PIPERIDINYL)OXY]-3-(7-AMIDINO-2-NAPHTHYL)PROPIONIC ACID
Authors:Stubbs, M.T.
Deposit date:1997-05-16
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
FEBS Lett., 375, 1995
1MTV
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, (+)-2-[4-[(-1-ACETIMIDOYL-4-PIPERIDINYL)OXY]-3-(7-AMIDINO-2-NAPHTHYL)PROPIONIC ACID
Authors:Stubbs, M.T.
Deposit date:1997-05-16
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
FEBS Lett., 375, 1995
1MTW
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, (2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-[4-({(3R)-1-[(1Z)-ethanimidoyl]pyrrolidin-3-yl}oxy)phenyl]propanoic acid
Authors:Stubbs, M.T.
Deposit date:1997-05-16
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
FEBS Lett., 375, 1995
1QL7
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Stubbs, M.T.
Deposit date:1999-08-24
Release date:2000-08-25
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ph-Dependent Binding Modes Observed in Trypsin Crystals: Lessons for the Structure-Based Drug Design
Chembiochem, 3, 2002
1QL8
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Stubbs, M.T.
Deposit date:1999-08-24
Release date:2000-08-25
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Ph-Dependent Binding Modes Observed in Trypsin Crystals: Lessons for the Structure-Based Drug Design
Chembiochem, 3, 2002
1FPH
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THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUDIN, ...
Authors:Stubbs, M.T., Bode, W.
Deposit date:1993-04-21
Release date:1994-01-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The interaction of thrombin with fibrinogen. A structural basis for its specificity.
Eur.J.Biochem., 206, 1992
1LDT
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COMPLEX OF LEECH-DERIVED TRYPTASE INHIBITOR WITH PORCINE TRYPSIN
Descriptor:TRYPSIN, TRYPTASE INHIBITOR, CALCIUM ION
Authors:Stubbs, M.T.
Deposit date:1997-05-15
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.
J.Biol.Chem., 272, 1997
1STF
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THE REFINED 2.4 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF RECOMBINANT HUMAN STEFIN B IN COMPLEX WITH THE CYSTEINE PROTEINASE PAPAIN: A NOVEL TYPE OF PROTEINASE INHIBITOR INTERACTION
Descriptor:PAPAIN, STEFIN B (CYSTATIN B)
Authors:Stubbs, M.T., Laber, B., Bode, W.
Deposit date:1993-04-21
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.
EMBO J., 9, 1990
1J14
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BENZAMIDINE IN COMPLEX WITH RAT TRYPSIN MUTANT X99RT
Descriptor:trypsin II, anionic, CALCIUM ION, ...
Authors:Stubbs, M.T.
Deposit date:2002-11-30
Release date:2002-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Reconstructing the Binding Site of Factor Xa in Trypsin Reveals Ligand-induced Structural Plasticity
J.MOL.BIOL., 325, 2003
1J15
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BENZAMIDINE IN COMPLEX WITH RAT TRYPSIN MUTANT X99/175/190RT
Descriptor:Trypsin II, anionic, CALCIUM ION, ...
Authors:Stubbs, M.T.
Deposit date:2002-11-30
Release date:2002-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reconstructing the Binding Site of Factor Xa in Trypsin Reveals Ligand-induced Structural Plasticity
J.MOL.BIOL., 325, 2003
1J16
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BENZAMIDINE IN COMPLEX WITH RAT TRYPSIN MUTANT X99/175/190RT
Descriptor:Trypsin II, anionic, CALCIUM ION, ...
Authors:Stubbs, M.T.
Deposit date:2002-11-30
Release date:2002-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Reconstructing the Binding Site of Factor Xa in Trypsin Reveals Ligand-induced Structural Plasticity
J.MOL.BIOL., 325, 2003
1J17
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH RAT TRYPSIN MUTANT X99/175/190RT
Descriptor:Trypsin II, anionic, CALCIUM ION, ...
Authors:Stubbs, M.T.
Deposit date:2002-11-30
Release date:2002-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reconstructing the Binding Site of Factor Xa in Trypsin Reveals Ligand-induced Structural Plasticity
J.MOL.BIOL., 325, 2003
1TFX
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COMPLEX OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR WITH PORCINE TRYPSIN
Descriptor:TRYPSIN, TISSUE FACTOR PATHWAY INHIBITOR, CALCIUM ION
Authors:Stubbs, M.T., Huber, R.
Deposit date:1997-01-21
Release date:1998-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
J.Mol.Biol., 269, 1997
1K1I
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BOVINE TRYPSIN-INHIBITOR COMPLEX
Descriptor:TRYPSIN, CALCIUM ION, N-ALPHA-(2-NAPHTHYLSULFONYL)-N-(3-AMIDINO-L-PHENYLALANINYL)-D-PIPECOLINIC ACID
Authors:Stubbs, M.T.
Deposit date:2001-09-25
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K1J
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BOVINE TRYPSIN-INHIBITOR COMPLEX
Descriptor:TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Stubbs, M.T.
Deposit date:2001-09-25
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K1L
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BOVINE TRYPSIN-INHIBITOR COMPLEX
Descriptor:TRYPSIN, SULFATE ION, CALCIUM ION, ...
Authors:Stubbs, M.T.
Deposit date:2001-09-25
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K1M
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BOVINE TRYPSIN-INHIBITOR COMPLEX
Descriptor:TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Stubbs, M.T.
Deposit date:2001-09-25
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K1N
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BOVINE TRYPSIN-INHIBITOR COMPLEX
Descriptor:TRYPSIN, CALCIUM ION, [N-[N-(4-METHOXY-2,3,6-TRIMETHYLPHENYLSULFONYL)-L-ASPARTYL]-D-(4-AMIDINO-PHENYLALANYL)]-PIPERIDINE
Authors:Stubbs, M.T.
Deposit date:2001-09-25
Release date:2001-11-28
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K1O
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BOVINE TRYPSIN-INHIBITOR COMPLEX
Descriptor:TRYPSIN, CALCIUM ION, {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)AMINO]CARBONYL}PIPERIDINYL)-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]AMINO}ACETIC ACID
Authors:Stubbs, M.T.
Deposit date:2001-09-25
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K1P
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BOVINE TRYPSIN-INHIBITOR COMPLEX
Descriptor:TRYPSIN, CALCIUM ION, [((1R)-2-{(2S)-2-[({4-[AMINO(IMINO)METHYL]BENZYL}AMINO)CARBONYL]AZETIDINYL}-1-CYCLOHEXYL-2-OXOETHYL)AMINO]ACETIC ACID
Authors:Stubbs, M.T.
Deposit date:2001-09-25
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K21
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HUMAN THROMBIN-INHIBITOR COMPLEX
Descriptor:Prothrombin, Hirudin variant-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Stubbs, M.T., Musil, D.
Deposit date:2001-09-26
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1K22
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HUMAN THROMBIN-INHIBITOR COMPLEX
Descriptor:Prothrombin, Hirudin variant-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Stubbs, M.T., Musil, D.
Deposit date:2001-09-26
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
1QL9
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FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH RAT TRYPSIN MUTANT X99RT
Descriptor:TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Stubbs, M.T.
Deposit date:1999-08-24
Release date:2000-08-25
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Reconstructing the Binding Site of Factor Xa in Trypsin Reveals Ligand-Induced Structural Plasticity
J.Mol.Biol., 325, 2003
1V2J
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BENZAMIDINE IN COMPLEX WITH BOVINE TRYPSIN VARIANT X(SSRI)BT.C1
Descriptor:Trypsin, SULFATE ION, CALCIUM ION, ...
Authors:Rauh, D., Klebe, G., Stubbs, M.T.
Deposit date:2003-10-17
Release date:2004-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Understanding protein-ligand interactions: the price of protein flexibility
J.Mol.Biol., 335, 2004