6BS9
 
 | | Stage III sporulation protein AB (SpoIIIAB) | | Descriptor: | SULFATE ION, Stage III sporulation protein AB | | Authors: | Strynadka, N.C.J, Zeytuni, N, Camp, A.H, Flanagan, K.A. | | Deposit date: | 2017-12-01 | | Release date: | 2018-01-17 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Structural characterization of SpoIIIAB sporulation-essential protein in Bacillus subtilis.
J. Struct. Biol., 202, 2018
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6DCS
 | | Stage III sporulation protein AF (SpoIIIAF) | | Descriptor: | SULFATE ION, Stage III sporulation protein AF | | Authors: | Strynadka, N.C.J, Zeytuni, N, Camp, A.H, Flanagan, K.A. | | Deposit date: | 2018-05-08 | | Release date: | 2018-07-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and biochemical characterization of SpoIIIAF, a component of a sporulation-essential channel in Bacillus subtilis.
J. Struct. Biol., 204, 2018
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6N7O
 | | Crystal structure of GIL01 gp7 | | Descriptor: | GIL01 gp7, IODIDE ION | | Authors: | Caveney, N.A, Strynadka, N.C.J. | | Deposit date: | 2018-11-27 | | Release date: | 2019-05-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Insights into Bacteriophage GIL01 gp7 Inhibition of Host LexA Repressor.
Structure, 27, 2019
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7UZ2
 | | Structure of beta-glycosidase from Sulfolobus solfataricus in complex with C5a-fluoro-valienide. | | Descriptor: | (1R,2S,3R,4R)-5-fluoro-6-(hydroxymethyl)cyclohex-5-ene-1,2,3,4-tetrol, Beta-galactosidase | | Authors: | Danby, P.M, Jeong, A, Sim, L, Sweeney, R.P, Wardman, J.F, Geissner, A, Worrall, L.J, Strynadka, N.C.J, Withers, S.G. | | Deposit date: | 2022-05-08 | | Release date: | 2023-04-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors.
Angew.Chem.Int.Ed.Engl., 62, 2023
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7UZ1
 | | Structure of beta-glycosidase from Sulfolobus solfataricus in complex with C5a-bromo-valienide. | | Descriptor: | (1R,2S,3R,4R)-5-bromo-6-(hydroxymethyl)cyclohex-5-ene-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Beta-galactosidase | | Authors: | Danby, P.M, Jeong, A, Sim, L, Sweeney, R.P, Wardman, J.F, Karimi, R, Geissner, A, Worrall, L.J, Strynadka, N.C.J, Withers, S.G. | | Deposit date: | 2022-05-08 | | Release date: | 2023-04-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors.
Angew.Chem.Int.Ed.Engl., 62, 2023
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7TC6
 | | All Phe-Azurin variant - F15W | | Descriptor: | Azurin, COPPER (II) ION, NITRATE ION | | Authors: | Fedoretz-Maxwell, B.P, Worrall, L.J, Strynadka, N.C.J, Warren, J.J. | | Deposit date: | 2021-12-22 | | Release date: | 2022-06-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The Impact of Second Coordination Sphere Methionine-Aromatic Interactions in Copper Proteins.
Inorg.Chem., 61, 2022
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7TC5
 | | All Phe-Azurin variant - F15Y | | Descriptor: | Azurin, COPPER (II) ION, NITRATE ION, ... | | Authors: | Fedoretz-Maxwell, B.P, Worrall, L.J, Strynadka, N.C.J, Warren, J.J. | | Deposit date: | 2021-12-22 | | Release date: | 2022-06-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The Impact of Second Coordination Sphere Methionine-Aromatic Interactions in Copper Proteins.
Inorg.Chem., 61, 2022
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6DUZ
 | | Structure of the periplasmic domains of PrgH and PrgK from the assembled Salmonella type III secretion injectisome needle complex | | Descriptor: | Lipoprotein PrgK, Protein PrgH | | Authors: | Hu, J, Worrall, L.J, Vuckovic, M, Atkinson, C.E, Strynadka, N.C.J. | | Deposit date: | 2018-06-22 | | Release date: | 2018-10-03 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin.
Nat Commun, 9, 2018
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6DZ8
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8SXR
 | | Crystal structure of SARS-CoV-2 Mpro with C5a | | Descriptor: | 3C-like proteinase nsp5, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(5-hydroxyisoquinolin-4-yl)acetamide | | Authors: | Worrall, L.J, Kenward, C, Lee, J, Strynadka, N.C.J. | | Deposit date: | 2023-05-23 | | Release date: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.114 Å) | | Cite: | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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7LBU
 | | Crystal structure of the Propionibacterium acnes surface sialidase | | Descriptor: | ACETATE ION, Exo-alpha-sialidase, PHOSPHATE ION | | Authors: | Yu, A.C.Y, Volkers, G, Strynadka, N.C.J. | | Deposit date: | 2021-01-08 | | Release date: | 2021-12-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Crystal structure of the Propionibacterium acnes surface sialidase, a drug target for P. acnes-associated diseases.
Glycobiology, 32, 2022
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7LBV
 | | Crystal structure of the Propionibacterium acnes surface sialidase in complex with Neu5Ac2en | | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, Exo-alpha-sialidase, PHOSPHATE ION | | Authors: | Yu, A.C.Y, Volkers, G, Strynadka, N.C.J. | | Deposit date: | 2021-01-09 | | Release date: | 2021-12-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of the Propionibacterium acnes surface sialidase, a drug target for P. acnes-associated diseases.
Glycobiology, 32, 2022
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7LQ6
 | | CryoEM structure of Escherichia coli PBP1b | | Descriptor: | Penicillin-binding protein 1B | | Authors: | Caveney, N.A, Workman, S.D, Yan, R, Atkinson, C.E, Yu, Z, Strynadka, N.C.J. | | Deposit date: | 2021-02-13 | | Release date: | 2021-05-26 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | CryoEM structure of the antibacterial target PBP1b at 3.3 angstrom resolution.
Nat Commun, 12, 2021
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8V34
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8V33
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8VA1
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2DRJ
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2F2H
 | | Structure of the YicI thiosugar Michaelis complex | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-NITROPHENYL 6-THIO-6-S-ALPHA-D-XYLOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE, GLYCEROL, ... | | Authors: | Kim, Y.-W, Lovering, A.L, Strynadka, N.C.J, Withers, S.G. | | Deposit date: | 2005-11-16 | | Release date: | 2006-02-28 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Expanding the Thioglycoligase Strategy to the Synthesis of alpha-linked Thioglycosides Allows Structural Investigation of the Parent Enzyme/Substrate Complex
J.Am.Chem.Soc., 128, 2006
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8EXQ
 | | Cryo-EM structure of S. aureus BlaR1 with C1 symmetry | | Descriptor: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | Authors: | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | Deposit date: | 2022-10-25 | | Release date: | 2023-01-11 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXS
 | | Cryo-EM structure of S. aureus BlaR1 F284A mutant | | Descriptor: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | Authors: | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | | Deposit date: | 2022-10-25 | | Release date: | 2023-01-11 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXP
 | | Cryo-EM structure of S. aureus BlaR1 with C2 symmetry | | Descriptor: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | Authors: | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | Deposit date: | 2022-10-25 | | Release date: | 2023-01-11 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXR
 | | Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain | | Descriptor: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Beta-lactam sensor/signal transducer BlaR1, PHOSPHATE ION, ... | | Authors: | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | Deposit date: | 2022-10-25 | | Release date: | 2023-01-11 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXT
 | | Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin | | Descriptor: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | Authors: | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | | Deposit date: | 2022-10-25 | | Release date: | 2023-01-11 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8FFJ
 | | Structure of Zanidatamab bound to HER2 | | Descriptor: | Receptor tyrosine-protein kinase erbB-2, Zanidatamab Heavy Chain A, Zanidatamab Heavy Chain B, ... | | Authors: | Worrall, L.J, Atkinson, C.E, Sanches, M, Dixit, S, Strynadka, N.C.J. | | Deposit date: | 2022-12-08 | | Release date: | 2023-02-22 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Zanidatamab, an Anti-HER2 Biparatopic that Induces Unique Surface HER2 Clusters and Complement-Dependent Cytotoxicity
To be Published
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1KN9
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