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5PTP
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STRUCTURE OF HYDROLASE (SERINE PROTEINASE)
Descriptor:BETA TRYPSIN, CALCIUM ION
Authors:Stroud, R.M., Finer-Moore, J.
Deposit date:1997-03-31
Release date:1997-07-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
Proteins, 12, 1992
1BTW
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EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE
Descriptor:BETA-TRYPSIN, N-(tert-butoxycarbonyl)-L-alanyl-N-{(1S)-5-ammonio-1-[hydroxy(3-hydroxypropoxy)boranyl]pentyl}-L-valinamide, CALCIUM ION
Authors:Stroud, R.M., Katz, B.A., Finer-Moore, J.
Deposit date:1995-05-17
Release date:1995-10-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Biochemistry, 34, 1995
1BTX
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EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE
Descriptor:BETA-TRYPSIN, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1S)-5-amino-1-(diethoxyboranyl)pentyl]-L-valinamide, CALCIUM ION
Authors:Stroud, R.M., Katz, B.A., Finer-Moore, J.
Deposit date:1995-05-17
Release date:1995-10-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Biochemistry, 34, 1995
1BTY
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CRYSTAL STRUCTURE OF BETA-TRYPSIN IN COMPLEX WITH BENZAMIDINE
Descriptor:BETA-TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Stroud, R.M., Katz, B.A., Finer-Moore, J.
Deposit date:1995-05-17
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Biochemistry, 34, 1995
1BTZ
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EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE
Descriptor:BETA-TRYPSIN, N-(tert-butoxycarbonyl)-L-alanyl-N-{(1R)-5-ammonio-1-[hydroxy(methoxy)boranyl]pentyl}-L-valinamide, CALCIUM ION
Authors:Stroud, R.M., Katz, B.A., Finer-Moore, J.
Deposit date:1995-05-17
Release date:1995-10-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Biochemistry, 34, 1995
1CN4
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ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR
Descriptor:PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (ERYTHROPOIETIN)
Authors:Stroud, R.M., Reid, S.W.
Deposit date:1999-05-25
Release date:1999-08-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature, 395, 1998
6NNR
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HIGH-RESOLUTION STRUCTURE OF WILD-TYPE E. COLI THYMIDYLATE SYNTHASE
Descriptor:Thymidylate synthase, 2'-deoxy-5'-uridylic acid, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ...
Authors:Stroud, R.M., Finer-Moore, J.
Deposit date:2019-01-15
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.
J. Am. Chem. Soc., 135, 2013
1DPO
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STRUCTURE OF RAT TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Stroud, R.M.
Deposit date:1997-03-31
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.
Proteins, 10, 1991
2TRM
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THE THREE-DIMENSIONAL STRUCTURE OF ASN102 MUTANT OF TRYPSIN. ROLE OF ASP102 IN SERINE PROTEASE CATALYSIS
Descriptor:TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Stroud, R.M., Finer-Moore, J.
Deposit date:1988-04-25
Release date:1988-07-16
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Science, 237, 1987
3E2J
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CRYSTAL STRUCTURE OF BOVINE COUPLING FACTOR B
Descriptor:ATP synthase subunit s, mitochondrial, MAGNESIUM ION
Authors:Stroud, R.M., Lee, J.K., Belogrudov, G.I.
Deposit date:2008-08-05
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of bovine mitochondrial factor B at 0.96-A resolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3E3Z
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CRYSTAL STRUCTURE OF BOVINE COUPLING FACTOR B BOUND WITH PHENYLARSINE OXIDE
Descriptor:ATP synthase subunit s, mitochondrial, MAGNESIUM ION, ...
Authors:Stroud, R.M., Lee, J.K., Belogrudov, G.I.
Deposit date:2008-08-08
Release date:2008-08-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of bovine mitochondrial factor B at 0.96-A resolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3E4G
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CRYSTAL STRUCTURE OF BOVINE COUPLING FACTOR B, G28E MUTANT
Descriptor:ATP synthase subunit s, mitochondrial, MAGNESIUM ION, ...
Authors:Stroud, R.M., Lee, J.K., Belogrudov, G.I.
Deposit date:2008-08-11
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal structure of bovine mitochondrial factor B at 0.96-A resolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5ICD
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REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
9ICD
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CATALYTIC MECHANISM OF NADP+-DEPENDENT ISOCITRATE DEHYDROGENASE: IMPLICATIONS FROM THE STRUCTURES OF MAGNESIUM-ISOCITRATE AND NADP+ COMPLEXES
Descriptor:ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Hurley, J.H., Dean, A.M., Koshland Jr., D.E., Stroud, R.M.
Deposit date:1991-07-29
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes.
Biochemistry, 30, 1991
1BJG
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D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING
Descriptor:THYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID
Authors:Sage, C.R., Michelitsch, M.D., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-06-25
Release date:1998-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry, 37, 1998
1BO7
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THYMIDYLATE SYNTHASE R179T MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BO8
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THYMIDYLATE SYNTHASE R178T MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, URIDINE-5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-10
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP0
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THYMIDYLATE SYNTHASE R23I MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R., Finer-Moore, J., Stroud, R.M.
Deposit date:1998-08-11
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BP6
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THYMIDYLATE SYNTHASE R23I, R179T DOUBLE MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R.J., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-13
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BPJ
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THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT
Descriptor:PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Morse, R.J., Finer-Moore, J.S., Stroud, R.M.
Deposit date:1998-08-11
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1JMF
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1JMG
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1JMH
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1JMI
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CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE
Descriptor:THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-09-13
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276, 1998
1SJS
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ACCESS TO PHOSPHORYLATION IN ISOCITRATE DEHYDROGENASE MAY OCCUR BY DOMAIN SHIFTING
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Finer-Moore, J., Stroud, R.M.
Deposit date:1997-07-08
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting.
Biochemistry, 36, 1997