Author results

3FCF
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COMPLEX OF UNG2 AND A FRAGMENT-BASED DESIGNED INHIBITOR
Descriptor:Uracil-DNA glycosylase, 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid, THIOCYANATE ION
Authors:Bianchet, M.A., Chung, S., Parker, J.B., Amzel, L.M., Stivers, J.T.
Deposit date:2008-11-21
Release date:2009-04-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Nat.Chem.Biol., 5, 2009
3FCI
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COMPLEX OF UNG2 AND A FRAGMENT-BASED DESIGNED INHIBITOR
Descriptor:Uracil-DNA glycosylase, 3-{(E)-[(3-{[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]amino}propoxy)imino]methyl}benzoic acid, SODIUM ION, ...
Authors:Bianchet, M.A., Chung, S., Parker, J.B., Amzel, L.M., Stivers, J.T.
Deposit date:2008-11-21
Release date:2009-04-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Nat.Chem.Biol., 5, 2009
3FCK
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COMPLEX OF UNG2 AND A FRAGMENT-BASED DESIGN INHIBITOR
Descriptor:Uracil-DNA glycosylase, 3-({[3-({[(1E)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylidene]amino}oxy)propyl]amino}methyl)benzoic acid
Authors:Bianchet, M.A., Chung, S., Parker, J.B., Amzel, L.M., Stivers, J.T.
Deposit date:2008-11-21
Release date:2009-04-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Nat.Chem.Biol., 5, 2009
3FCL
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COMPLEX OF UNG2 AND A FRAGMENT-BASED DESIGNED INHIBITOR
Descriptor:Uracil-DNA glycosylase, 3-{[(4-{[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]amino}butyl)amino]methyl}benzoic acid, THIOCYANATE ION
Authors:Bianchet, M.A., Chung, S., Parker, J.B., Amzel, L.M., Stivers, J.T.
Deposit date:2008-11-21
Release date:2009-04-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Nat.Chem.Biol., 5, 2009
1FLZ
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URACIL DNA GLYCOSYLASE WITH UAAP
Descriptor:URACIL-DNA GLYCOSYLASE, URACIL
Authors:Werner, R.M., Jiang, Y.L., Gordley, R.G., Jagadeesh, G.J., Ladner, J.E., Xiao, G., Tordova, M., Gilliland, G.L., Stivers, J.T.
Deposit date:2000-08-15
Release date:2001-01-17
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase.
Biochemistry, 39, 2000
2HXM
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COMPLEX OF UNG2 AND A SMALL MOLECULE SYNTHETIC INHIBITOR
Descriptor:Uracil-DNA glycosylase, 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID
Authors:Bianchet, M.A., Krosky, D.J., Ghung, S., Seiple, L., Amzel, L.M., Stivers, J.T.
Deposit date:2006-08-03
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Mimicking damaged DNA with a small molecule inhibitor of human UNG2.
Nucleic Acids Res., 34, 2006
1EUG
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor:PROTEIN (GLYCOSYLASE)
Authors:Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A.C., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-10-12
Release date:1999-10-12
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
1LMZ
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SOLUTION STRUCTURE OF 3-METHYLADENINE DNA GLYCOSYLASE I (TAG)
Descriptor:3-methyladenine DNA glycosylase I (TAG)
Authors:Drohat, A.C., Kwon, K., Krosky, D.J., Stivers, J.T.
Deposit date:2002-05-02
Release date:2002-08-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:3-Methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member.
Nat.Struct.Biol., 9, 2002
1NKU
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NMR SOLUTION STRUCTURE OF ZINC-BINDING PROTEIN 3-METHYLADENINE DNA GLYCOSYLASE I (TAG)
Descriptor:3-Methyladenine Dna Glycosylase I (TAG), ZINC ION
Authors:Kwon, K., Cao, C., Stivers, J.T.
Deposit date:2003-01-03
Release date:2003-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Novel Zinc Snap Motif Conveys Structural Stability to 3-Methyladenine DNA Glycosylase I
J.Biol.Chem., 278, 2003
1P7M
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SOLUTION STRUCTURE AND BASE PERTURBATION STUDIES REVEAL A NOVEL MODE OF ALKYLATED BASE RECOGNITION BY 3-METHYLADENINE DNA GLYCOSYLASE I
Descriptor:DNA-3-methyladenine glycosylase I, ZINC ION, 3-METHYL-3H-PURIN-6-YLAMINE
Authors:Cao, C., Kwon, K., Jiang, Y.L., Drohat, A.C., Stivers, J.T.
Deposit date:2003-05-02
Release date:2003-11-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I
J.Biol.Chem., 278, 2003
1Q3F
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URACIL DNA GLYCOSYLASE BOUND TO A CATIONIC 1-AZA-2'-DEOXYRIBOSE-CONTAINING DNA
Descriptor:5'-D(*TP*GP*TP*(NRI)P*AP*TP*CP*TP*T)-3', 5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*A)-3', Uracil-DNA glycosylase, ...
Authors:Bianchet, M.A., Seiple, L.A., Jiang, Y.L., Ichikawa, Y., Amzel, L.M., Stivers, J.T.
Deposit date:2003-07-29
Release date:2004-03-23
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase.
Biochemistry, 42, 2003
2EUG
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor:PROTEIN (GLYCOSYLASE), URACIL
Authors:Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A.C., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
2OXM
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CRYSTAL STRUCTURE OF A UNG2/MODIFIED DNA COMPLEX THAT REPRESENT A STABILIZED SHORT-LIVED EXTRAHELICAL STATE IN EZYMATIC DNA BASE FLIPPING
Descriptor:DNA (5'-D(*TP*GP*TP*TP*AP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*TP*(4MF)P*AP*CP*A)-3'), Uracil-DNA glycosylase
Authors:Bianchet, M.A., Krosky, D.J., Stivers, J.T., Amzel, L.M.
Deposit date:2007-02-20
Release date:2007-10-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
Nature, 449, 2007
2OYT
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CRYSTAL STRUCTURE OF UNG2/DNA(TM)
Descriptor:Uracil-DNA glycosylase, DNA strand1, DNA strand2
Authors:Bianchet, M.A., Krosky, D.J., Stivers, J.T., Amzel, L.M.
Deposit date:2007-02-22
Release date:2007-10-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
Nature, 449, 2007
3EUG
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor:PROTEIN (GLYCOSYLASE), GLYCEROL
Authors:Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A.C., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
4EUG
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CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX
Descriptor:PROTEIN (GLYCOSYLASE)
Authors:Xiao, G., Tordova, M., Drohat, A.C., Jagadeesh, J., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-12-27
Release date:1999-07-23
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.
Biochemistry, 38, 1999
5EUG
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CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX
Descriptor:PROTEIN (GLYCOSYLASE), URACIL
Authors:Xiao, G., Tordova, M., Drohat, A.C., Jagadeesh, J., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-12-27
Release date:1999-07-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999