Author results

1DM9
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HEAT SHOCK PROTEIN 15 KD
分子名称:HYPOTHETICAL 15.5 KD PROTEIN IN MRCA-PCKA INTERGENIC REGION, SULFATE ION
著者Staker, B.L., Korber, P., Bardwell, J.C.A., Saper, M.A.
登録日1999-12-14
公開日2000-02-18
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of Hsp15 reveals a novel RNA-binding motif.
EMBO J., 19, 2000
1K4S
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HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
分子名称:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ...
著者Staker, B.L., Hjerrild, K., Feese, M.D., Behnke, C.A., Burgin Jr., A.B., Stewart, L.J.
登録日2001-10-08
公開日2002-12-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1K4T
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON TOPOTECAN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
分子名称:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
著者Staker, B.L., Hjerrild, K., Feese, M.D., Behnke, C.A., Burgin Jr., A.B., Stewart, L.J.
登録日2001-10-08
公開日2002-12-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA, 99, 2002
1SC7
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDENOISOQUINOLINE MJ-II-38 AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
分子名称:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
著者Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
登録日2004-02-11
公開日2005-04-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1SEU
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDOLOCARBAZOLE SA315F AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
分子名称:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
著者Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
登録日2004-02-18
公開日2005-04-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
1T8I
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HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON CAMPTOTHECIN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
分子名称:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
著者Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
登録日2004-05-12
公開日2005-05-31
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
J.Med.Chem., 48, 2005
3I4E
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CRYSTAL STRUCTURE OF ISOCITRATE LYASE FROM BURKHOLDERIA PSEUDOMALLEI
分子名称:Isocitrate lyase
著者Staker, B.L., Arakaki, T., Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-07-01
公開日2009-07-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Crystal structure of Isocitrate Lyase from Burkholderia pseudomallei
To be Published
3IEW
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE FROM BURKHOLDERIA PSEUDOMALLEI WITH BOUND CTP AND CDP
分子名称:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ...
著者Staker, B.L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-07-23
公開日2009-08-18
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
J Struct Funct Genomics, 12, 2011
3BL7
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG156844
分子名称:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
著者Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
登録日2007-12-10
公開日2008-10-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BL9
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG157493
分子名称:Scavenger mRNA-decapping enzyme DcpS, 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
著者Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
登録日2007-12-10
公開日2008-10-21
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3BLA
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SYNTHETIC GENE ENCODED DCPS BOUND TO INHIBITOR DG153249
分子名称:Scavenger mRNA-decapping enzyme DcpS, 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
著者Staker, B.L., Christensen, J., Stewart, L., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
登録日2007-12-10
公開日2008-10-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献DcpS as a therapeutic target for spinal muscular atrophy.
Acs Chem.Biol., 3, 2008
3G45
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4B WITH REGULATORY DOMAIN AND D155988
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
著者Staker, B.L.
登録日2009-02-03
公開日2010-01-19
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4G
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
著者Staker, B.L.
登録日2009-02-03
公開日2010-01-19
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4I
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
著者Staker, B.L.
登録日2009-02-03
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4K
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
著者Staker, B.L.
登録日2009-02-03
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G4L
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
著者Staker, B.L.
登録日2009-02-03
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3G58
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
著者Staker, B.L.
登録日2009-02-04
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3HZG
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE SYNTHASE X BOUND WITH FAD
分子名称:Thymidylate synthase thyX, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Staker, B.L., Rathod, P., Hunter, J., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-06-23
公開日2009-07-07
最終更新日2015-04-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3IAD
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-{4-[(2-fluoro-6-methoxy-3'-nitrobiphenyl-3-yl)methyl]phenyl}urea, ZINC ION, ...
著者Staker, B.L., Burgin Jr., A.B.
登録日2009-07-13
公開日2010-01-05
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nat.Biotechnol., 28, 2010
3IML
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE FROM BURKHOLDERIA PSEUDOMALLEI
分子名称:S-adenosylmethionine synthetase
著者Staker, B.L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-08-10
公開日2009-09-22
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
3L56
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CRYSTAL STRUCTURE OF THE LARGE C-TERMINAL DOMAIN OF POLYMERASE BASIC PROTEIN 2 FROM INFLUENZA VIRUS A/VIET NAM/1203/2004 (H5N1)
分子名称:Polymerase PB2
著者Staker, B.L., Edwards, T., Eric, S., Raymond, A., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-12-21
公開日2010-03-09
最終更新日2012-05-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3GMT
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CRYSTAL STRUCTURE OF ADENYLATE KINASE FROM BURKHOLDERIA PSEUDOMALLEI
分子名称:Adenylate kinase, SULFATE ION
著者Abendroth, J., Staker, B.L., Robinson, H., Buchko, G.W., Hewitt, S.N., Napuli, A.J., Van Voorhis, W., Stacy, R., Myler, P.J., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-03-15
公開日2009-06-02
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state.
Biochem.Biophys.Res.Commun., 394, 2010
1EIZ
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FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE
分子名称:FTSJ, S-ADENOSYLMETHIONINE
著者Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C.A., Jakob, U.
登録日2000-02-29
公開日2000-08-30
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献RNA methylation under heat shock control.
Mol.Cell, 6, 2000
1EJ0
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FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE, MERCURY DERIVATIVE
分子名称:FTSJ, MERCURY (II) ION, S-ADENOSYLMETHIONINE
著者Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C.A., Jakob, U.
登録日2000-02-29
公開日2000-08-30
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献RNA methylation under heat shock control.
Mol.Cell, 6, 2000
1RR8
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STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
分子名称:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ...
著者Chrencik, J.E., Staker, B.L., Burgin, A.B., Stewart, L., Redinbo, M.R.
登録日2003-12-08
公開日2004-07-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004