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1TAD
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BU of 1tad by Molmil
GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4-
Descriptor: CACODYLATE ION, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Sondek, J, Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B.
Deposit date:1995-01-05
Release date:1995-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4.
Nature, 372, 1994
4K45
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BU of 4k45 by Molmil
Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide
Authors:Sondek, J, Hajicek, N.
Deposit date:2013-04-11
Release date:2013-06-26
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes.
Biochemistry, 52, 2013
7T8T
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BU of 7t8t by Molmil
CryoEM structure of PLCg1
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION
Authors:Endo-Streeter, S, Sondek, J.
Deposit date:2021-12-17
Release date:2022-12-21
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:CryoEM structure of PLCg1
To Be Published
1GOT
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BU of 1got by Molmil
HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
Descriptor: GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ...
Authors:Lambright, D.G, Sondek, J, Bohm, A, Skiba, N.P, Hamm, H.E, Sigler, P.B.
Deposit date:1996-08-07
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A crystal structure of a heterotrimeric G protein.
Nature, 379, 1996
2ZKM
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BU of 2zkm by Molmil
Crystal Structure of Phospholipase C Beta 2
Descriptor: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2, CALCIUM ION
Authors:Hicks, S.N, Jezyk, M.R, Gershberg, S, Seifert, J.P, Harden, T.K, Sondek, J.
Deposit date:2008-03-26
Release date:2008-08-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:General and versatile autoinhibition of PLC isozymes
Mol.Cell, 31, 2008
6PBC
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BU of 6pbc by Molmil
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION
Authors:Hajicek, N, Sondek, J.
Deposit date:2019-06-13
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
4K44
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BU of 4k44 by Molmil
Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Authors:Hajicek, N, Sondek, J.
Deposit date:2013-04-11
Release date:2013-06-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes.
Biochemistry, 52, 2013
7SQ2
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BU of 7sq2 by Molmil
Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, ACETATE ION, CALCIUM ION, ...
Authors:Endo-Streeter, S.T, Sondek, J, Harden, T.K.
Deposit date:2021-11-04
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex
Science, 330, 2010
1FOE
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BU of 1foe by Molmil
CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Descriptor: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION, T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1
Authors:Worthylake, D.K, Rossman, K.L, Sondek, J.
Deposit date:2000-08-27
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408, 2000
2FJU
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BU of 2fju by Molmil
Activated Rac1 bound to its effector phospholipase C beta 2
Descriptor: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CALCIUM ION, ...
Authors:Jezyk, M.R, Snyder, J.T, Harden, T.K, Sondek, J.
Deposit date:2006-01-03
Release date:2006-11-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nat.Struct.Mol.Biol., 13, 2006
1RJ2
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BU of 1rj2 by Molmil
Crystal structure of the DH/PH fragment of Dbs without bound GTPase
Descriptor: Guanine nucleotide exchange factor DBS [Fragment]
Authors:Worthylake, D.K, Rossman, K.L, Sondek, J.
Deposit date:2003-11-18
Release date:2004-06-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Structure, 12, 2004
1S28
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BU of 1s28 by Molmil
Crystal Structure of AvrPphF ORF1, the Chaperone for the Type III Effector AvrPphF ORF2 from P. syringae
Descriptor: ORF1, SULFATE ION
Authors:Singer, A.U, Desveaux, D, Betts, L, Chang, J.H, Nimchuk, Z, Grant, S.R, Dangl, J.L, Sondek, J.
Deposit date:2004-01-08
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
1S21
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BU of 1s21 by Molmil
Crystal Structure of AvrPphF ORF2, A Type III Effector from P. syringae
Descriptor: ORF2
Authors:Singer, A.U, Desveaux, D, Betts, L, Chang, J.H, Nimchuk, Z, Grant, S.R, Dangl, J.K, Sondek, J.
Deposit date:2004-01-07
Release date:2004-09-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
1IHJ
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BU of 1ihj by Molmil
Crystal Structure of the N-terminal PDZ domain of InaD in complex with a NorpA C-terminal peptide
Descriptor: InaD, phospholipase C
Authors:Kimple, M.E, Siderovski, D.P, Sondek, J.
Deposit date:2001-04-19
Release date:2001-08-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
EMBO J., 20, 2001
2NZ8
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BU of 2nz8 by Molmil
N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1
Descriptor: ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein
Authors:Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J.
Deposit date:2006-11-22
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
2PBI
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BU of 2pbi by Molmil
The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure
Descriptor: GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9
Authors:Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
1KZ7
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BU of 1kz7 by Molmil
Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42
Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1KZG
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BU of 1kzg by Molmil
DbsCdc42(Y889F)
Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1XO5
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BU of 1xo5 by Molmil
Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein
Descriptor: CALCIUM ION, Calcium and integrin-binding protein 1
Authors:Gentry, H.R, Singer, A.U, Betts, L, Yang, C, Ferrara, J.D, Parise, L.V, Sondek, J.
Deposit date:2004-10-05
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins
J.Biol.Chem., 280, 2005
1Y3A
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BU of 1y3a by Molmil
Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Johnston, C.A, Willard, F.S, Jezyk, M.R, Fredericks, Z, Bodor, E.T, Jones, M.B, Blaesius, R, Harden, T.K, Sondek, J, Watts, V.J, Ramer, J.K, Siderovski, D.P.
Deposit date:2004-11-24
Release date:2005-07-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
2NUD
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BU of 2nud by Molmil
The structure of the type III effector AvrB complexed with a high-affinity RIN4 peptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Avirulence B protein, RPM1-interacting protein 4, ...
Authors:Singer, A.U, Desveaux, D, Wu, A.J, McNulty, B, Sondek, J, Dangl, J.L.
Deposit date:2006-11-09
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.
Plos Pathog., 3, 2007
2NUN
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BU of 2nun by Molmil
The structure of the type III effector AvrB complexed with ADP
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Avirulence B protein
Authors:Singer, A.U, Desveaux, D, Wu, A.J, McNulty, B, Dangl, J.L, Sondek, J.
Deposit date:2006-11-09
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.
Plos Pathog., 3, 2007
2PZ1
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BU of 2pz1 by Molmil
Crystal Structure of Auto-inhibited Asef
Descriptor: Rho guanine nucleotide exchange factor 4
Authors:Betts, L, Sondek, J, Rossman, K.L.
Deposit date:2007-05-17
Release date:2007-08-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
1JAD
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BU of 1jad by Molmil
C-terminal Domain of Turkey PLC-beta
Descriptor: SULFATE ION, phospholipase C beta
Authors:Singer, A.U, Waldo, G.L, Harden, T.K, Sondek, J.
Deposit date:2001-05-30
Release date:2001-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.
Nat.Struct.Biol., 9, 2002
1KI1
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BU of 1ki1 by Molmil
Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42
Descriptor: G25K GTP-binding protein, placental isoform, SULFATE ION, ...
Authors:Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002

 

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