Author results

1BP3
  • Download 1bp3
  • View 1bp3
Molmil generated image of 1bp3
THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Descriptor:PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION
Authors:Somers, W., Ultsch, M., De Vos, A.M., Kossiakoff, A.A.
Deposit date:1998-08-12
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
1S1E
  • Download 1s1e
  • View 1s1e
Molmil generated image of 1s1e
CRYSTAL STRUCTURE OF KV CHANNEL-INTERACTING PROTEIN 1 (KCHIP-1)
Descriptor:Kv channel interacting protein 1, CALCIUM ION
Authors:Scannevin, R.H., Wang, K.-W., Jow, F., Megules, J., Kopsco, D.C., Edris, W., Carroll, K.C., Lu, Q., Xu, W.-X., Xu, Z.-B., Katz, A.H., Olland, S., Lin, L., Taylor, M., Stahl, M., Malakian, K., Somers, W., Mosyak, L., Bowlby, M.R., Chanda, P., Rhodes, K.J.
Deposit date:2004-01-06
Release date:2005-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron, 41, 2004
1S1G
  • Download 1s1g
  • View 1s1g
Molmil generated image of 1s1g
CRYSTAL STRUCTURE OF KV4.3 T1 DOMAIN
Descriptor:Potassium voltage-gated channel subfamily D member 3, ZINC ION
Authors:Scannevin, R.H., Wang, K.W., Jow, F., Megules, J., Kopsco, D.C., Edris, W., Carroll, K.C., Lu, Q., Xu, W.X., Xu, Z.B., Katz, A.H., Olland, S., Lin, L., Taylor, M., Stahl, M., Malakian, K., Somers, W., Mosyak, L., Bowlby, M.R., Chanda, P., Rhodes, K.J.
Deposit date:2004-01-06
Release date:2004-03-23
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron, 41, 2004
1KF9
  • Download 1kf9
  • View 1kf9
Molmil generated image of 1kf9
PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Descriptor:PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238)
Authors:Schiffer, C.A., Ultsch, M., Walsh, S., Somers, W., De Vos, A.M., Kossiakoff, A.A.
Deposit date:2001-11-19
Release date:2002-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
2RJP
  • Download 2rjp
  • View 2rjp
Molmil generated image of 2rjp
CRYSTAL STRUCTURE OF ADAMTS4 WITH INHIBITOR BOUND
Descriptor:ADAMTS-4, ZINC ION, CALCIUM ION, ...
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-15
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
2RJQ
  • Download 2rjq
  • View 2rjq
Molmil generated image of 2rjq
CRYSTAL STRUCTURE OF ADAMTS5 WITH INHIBITOR BOUND
Descriptor:ADAMTS-5, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-15
Release date:2007-12-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
3B2Z
  • Download 3b2z
  • View 3b2z
Molmil generated image of 3b2z
CRYSTAL STRUCTURE OF ADAMTS4 (APO FORM)
Descriptor:ADAMTS-4, ZINC ION, CALCIUM ION
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-19
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
1ALU
  • Download 1alu
  • View 1alu
Molmil generated image of 1alu
HUMAN INTERLEUKIN-6
Descriptor:INTERLEUKIN-6, SULFATE ION, L(+)-TARTARIC ACID
Authors:Somers, W.S., Stahl, M., Seehra, J.S.
Deposit date:1997-06-03
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
EMBO J., 16, 1997
4J12
  • Download 4j12
  • View 4j12
Molmil generated image of 4j12
MONOMERIC FC
Descriptor:human Fc fragment, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Ishino, T., Wang, M., Mosyak, L., Tam, A., Duan, W., Svenson, K., Joyce, A., O'Hara, D., Lin, L., Somers, W., Kriz, R.
Deposit date:2013-01-31
Release date:2013-05-01
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics.
J.Biol.Chem., 288, 2013
1HUW
  • Download 1huw
  • View 1huw
Molmil generated image of 1huw
THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
Descriptor:HUMAN GROWTH HORMONE
Authors:Ultsch, M.H., Somers, W.S., Kossiakoff, A.A., De Vos, A.M.
Deposit date:1993-09-22
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
5C2B
  • Download 5c2b
  • View 5c2b
Molmil generated image of 5c2b
ANTI-CXCL13 PARENTAL SCFV - 3B4
Descriptor:scFv 3B4 heavy chain, 3B4 light chain, CHLORIDE ION
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-15
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.4049 Å)
Cite:Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair
To Be Published
5C6W
  • Download 5c6w
  • View 5c6w
Molmil generated image of 5c6w
ANTI-CXCL13 SCFV - E10
Descriptor:Protein IGHV1-69-2,Ig lambda chain V-II region NIG-84, CHLORIDE ION, SULFATE ION, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-23
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair
To Be Published
5CBA
  • Download 5cba
  • View 5cba
Molmil generated image of 5cba
3B4 IN COMPLEX WITH CXCL13 - 3B4-CXCL13
Descriptor:3b4 heavy chain, 3b4 light chain, C-X-C motif chemokine 13, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J. Biol. Chem., 291, 2016
5CBE
  • Download 5cbe
  • View 5cbe
Molmil generated image of 5cbe
E10 IN COMPLEX WITH CXCL13
Descriptor:E10 heavy chain, E10 light chain, C-X-C motif chemokine 13, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J. Biol. Chem., 291, 2016
3FXY
  • Download 3fxy
  • View 3fxy
Molmil generated image of 3fxy
ACIDIC MAMMALIAN CHINASE, CATALYTIC DOMAIN
Descriptor:Acidic mammalian chitinase
Authors:Olland, A.M.
Deposit date:2009-01-21
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein Sci., 18, 2009
3FY1
  • Download 3fy1
  • View 3fy1
Molmil generated image of 3fy1
THE ACIDIC MAMMALIAN CHITINASE CATALYTIC DOMAIN IN COMPLEX WITH METHYLALLOSAMIDIN
Descriptor:Acidic mammalian chitinase, METHYL N-ACETYL ALLOSAMINE, N-ACETYL-D-ALLOSAMINE, ...
Authors:Olland, A.M.
Deposit date:2009-01-21
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein Sci., 18, 2009
4HGK
  • Download 4hgk
  • View 4hgk
Molmil generated image of 4hgk
SHARK IGNAR VARIABLE DOMAIN
Descriptor:Serum albumin, shark V-NAR antibody
Authors:Olland, A.O., Kovalenko, O.V., Svenson, K., King, D.
Deposit date:2012-10-08
Release date:2013-05-08
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis.
J.Biol.Chem., 288, 2013
4HGM
  • Download 4hgm
  • View 4hgm
Molmil generated image of 4hgm
SHARK IGNAR VARIABLE DOMAIN
Descriptor:Shark V-NAR, Serum albumin, 1,2-ETHANEDIOL, ...
Authors:Olland, A., Kovalenko, O.V., King, D., Svenson, K.
Deposit date:2012-10-08
Release date:2013-05-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis.
J.Biol.Chem., 288, 2013