Author results

5SXO
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1.35 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE II (FABF) FROM LISTERIA MONOCYTOGENES
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Soares da Costa, T.P., Nanson, J.D., Forwood, J.K.
Deposit date:2016-08-09
Release date:2016-11-02
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:1.35 angstrom resolution crystal structure of beta-ketoacyl-ACP synthase II (FabF) from Listeria monocytogenes
To Be Published
3I7Q
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DIHYDRODIPICOLINATE SYNTHASE MUTANT - K161A
Descriptor:Dihydrodipicolinate synthase, GLYCEROL, POTASSIUM ION, ...
Authors:Dobson, R.C.J., Jameson, G.B., Gerrard, J.A., Soares da Costa, T.P.
Deposit date:2009-07-08
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?
Biochimie, 92, 2010
3I7R
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DIHYDRODIPICOLINATE SYNTHASE - K161R
Descriptor:Dihydrodipicolinate synthase, POTASSIUM ION, GLYCEROL, ...
Authors:Dobson, R.C.J., Jameson, G.B., Gerrard, J.A., Soares da Costa, T.P.
Deposit date:2009-07-08
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?
Biochimie, 92, 2010
3I7S
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DIHYDRODIPICOLINATE SYNTHASE MUTANT - K161A - WITH THE SUBSTRATE PYRUVATE BOUND IN THE ACTIVE SITE.
Descriptor:Dihydrodipicolinate synthase, GLYCEROL, POTASSIUM ION, ...
Authors:Dobson, R.C.J., Jameson, G.B., Gerrard, J.A., Soares da Costa, T.P.
Deposit date:2009-07-08
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?
Biochimie, 92, 2010
5KT0
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DIHYDRODIPICOLINATE REDUCTASE FROM THE INDUSTRIAL AND EVOLUTIONARILY IMPORTANT CYANOBACTERIA ANABAENA VARIABILIS.
Descriptor:4-hydroxy-tetrahydrodipicolinate reductase, MAGNESIUM ION
Authors:Christensen, J.B., Soares da Costa, T.P., Faou, P., Pearce, F.G., Panjikar, S., Perugini, M.A.
Deposit date:2016-07-10
Release date:2016-09-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Dihydrodipicolinate Reductase from the industrial and evolutionarily important cyanobacteria Anabaena variabilis.
To Be Published
6P90
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CRYSTAL STRUCTURE OF PADHDPS2-H56Q MUTANT
Descriptor:4-hydroxy-tetrahydrodipicolinate synthase, GLYCEROL, CHLORIDE ION
Authors:Impey, R.E., Panjikar, S., Hall, C.J., Bock, L.J., Sutton, J.M., Perugini, M.A., Soares da Costa, T.P.
Deposit date:2019-06-08
Release date:2019-08-07
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation.
Febs J., 287, 2020
6UE0
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CRYSTAL STRUCTURE OF DIHYDRODIPICOLINATE SYNTHASE FROM KLEBSIELLA PNEUMONIAE BOUND TO PYRUVATE
Descriptor:4-hydroxy-tetrahydrodipicolinate synthase, SULFATE ION, CHLORIDE ION
Authors:Impey, R.E., Lee, M., Hawkins, D.A., Sutton, J.M., Panjikar, S., Perugini, M.A., Soares da Costa, T.P.
Deposit date:2019-09-20
Release date:2020-02-05
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens.
Febs Lett., 2020
4DQ2
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STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH BIOTINOL-5'-AMP
Descriptor:Biotin-[acetyl-CoA-carboxylase] ligase, ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE
Authors:Wilce, M., Yap, M., Pendini, N., Soares de Costa, T., Polyak, S., Tieu, W., Booker, G., Wallace, J.
Deposit date:2012-02-14
Release date:2012-04-18
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V7C
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CYSTAL STRUCTURE OF SABPL IN COMPLEX WITH INHIBITOR
Descriptor:Biotin ligase, 5'-deoxy-2',3'-O-(1-methylethylidene)-5'-(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)adenosine
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-20
Release date:2012-04-18
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V7R
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH INHIBITOR
Descriptor:Biotin ligase, (3aS,4S,6aR)-4-(5-{1-[4-(6-amino-9H-purin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-21
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V7S
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH INHIBITOR 0364
Descriptor:Biotin ligase, 5-methyl-3-[4-(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-21
Release date:2012-04-25
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V8J
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE
Descriptor:Biotin ligase
Authors:Pendini, N.R., Yap, M.Y.
Deposit date:2011-12-23
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V8K
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH BIOTIN
Descriptor:Biotin ligase, BIOTIN
Authors:Yap, M.Y., Pendini, N.R.
Deposit date:2011-12-23
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
3V8L
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS BIOTIN PROTEIN LIGASE IN COMPLEX WITH BIOTINYL-5'-AMP
Descriptor:Biotin ligase, BIOTINYL-5-AMP
Authors:Yap, M.Y.
Deposit date:2011-12-23
Release date:2012-12-26
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J.Biol.Chem., 287, 2012
5HN1
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CRYSTAL STRUCTURE OF INTERLEUKIN-37
Descriptor:Interleukin-37, SULFATE ION
Authors:Ellisdon, A.M., Nold-Petry, C.A., Nold, M.F., Whisstock, J.C.
Deposit date:2016-01-17
Release date:2017-02-22
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Sci Immunol, 2, 2017
5KTL
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DIHYDRODIPICOLINATE SYNTHASE FROM THE INDUSTRIAL AND EVOLUTIONARILY IMPORTANT CYANOBACTERIA ANABAENA VARIABILIS.
Descriptor:4-hydroxy-tetrahydrodipicolinate synthase, MANGANESE (II) ION
Authors:Christensen, J.B., Panjikar, S., Perugini, M.
Deposit date:2016-07-11
Release date:2016-11-30
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure and Function of Cyanobacterial DHDPS and DHDPR.
Sci Rep, 6, 2016
6BVT
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IMPORTIN ALPHA 1 IN CARGO FREE STATE
Descriptor:Importin subunit alpha-1
Authors:Smith, K.M., Tsimablyuk, S., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-13
Release date:2018-07-04
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BVV
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NIPAH VIRUS W PROTEIN C-TERMINUS IN COMPLEX WITH IMPORTIN ALPHA 3
Descriptor:Importin subunit alpha-3, Protein W
Authors:Smith, K.M., Tsimbalyuk, S., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-13
Release date:2018-07-04
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BVZ
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IMPORTIN ALPHA 3 IN CARGO FREE STATE
Descriptor:Importin subunit alpha-3
Authors:Smith, K.M., Tsimbalyuk, S., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BW0
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NIPAH VIRUS W PROTEIN C-TERMINUS IN COMPLEX WITH IMPORTIN ALPHA 1
Descriptor:Protein W, Importin subunit alpha-1
Authors:Smith, K.M., Tsimbalyuk, S., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BW1
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HENDRA VIRUS W PROTEIN C-TERMINUS IN COMPLEX WITH IMPORTIN ALPHA 1
Descriptor:Protein W, Importin subunit alpha-1
Authors:Tsimbalyuk, S., Smith, K.M., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BW9
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HENDRA VIRUS W PROTEIN C-TERMINUS IN COMPLEX WITH IMPORTIN ALPHA 3 CRYSTAL FORM 1
Descriptor:Importin subunit alpha-3, Protein W
Authors:Tsimbalyuk, S., Smith, K.M., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BWA
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HENDRA VIRUS W PROTEIN C-TERMINUS IN COMPLEX WITH IMPORTIN ALPHA 3 CRYSTAL FORM 2
Descriptor:Importin subunit alpha-3, Protein W
Authors:Tsimbalyuk, S., Smith, K.M., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BWB
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HENDRA VIRUS W PROTEIN C-TERMINUS IN COMPLEX WITH IMPORTIN ALPHA 3 CRYSTAL FORM 3
Descriptor:Importin subunit alpha-3, Protein W
Authors:Tsimbalyuk, S., Smith, K.M., Edwards, M.R., Aragao, D., Cross, E.M., Basler, C.F., Forwood, J.K.
Deposit date:2017-12-14
Release date:2018-07-04
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6DCN
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BCL-XL COMPLEX WITH BECLIN 1 BH3 DOMAIN T108PTHR
Descriptor:BCL-xl protein, Beclin-1
Authors:Lee, E.F., Smith, B.J., Smith, N.A., Yao, S., Fairlie, W.D.
Deposit date:2018-05-07
Release date:2018-05-23
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 15, 2019
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