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7UY0
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BU of 7uy0 by Molmil
Crystal structure of human Fgr tyrosine kinase in complex with A-419259
Descriptor: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ...
Authors:Du, S, Alvarado, J.J, Smithgall, T.E.
Deposit date:2022-05-06
Release date:2022-12-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr.
Structure, 30, 2022
7UY3
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BU of 7uy3 by Molmil
Crystal structure of human Fgr tyrosine kinase in complex with TL02-59
Descriptor: 1,2-ETHANEDIOL, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, ...
Authors:Du, S, Alvarado, J.J, Smithgall, T.E.
Deposit date:2022-05-06
Release date:2022-12-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr.
Structure, 30, 2022
8F2P
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BU of 8f2p by Molmil
Nef SF2 dimerization mutant bound to Hck SH3
Descriptor: C-terminal core protein, Tyrosine-protein kinase HCK
Authors:Thomas, C.E, Alvarado, J.J, Smithgall, T.E.
Deposit date:2022-11-08
Release date:2023-02-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers.
J.Mol.Biol., 435, 2023
4U5W
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BU of 4u5w by Molmil
Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ...
Authors:Alvarado, J.J, Yeh, J.I, Smithgall, T.E.
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.
J.Biol.Chem., 289, 2014
6B72
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BU of 6b72 by Molmil
A novel HIV-1 Nef dimer interface induced by a single octyl-glucoside molecule
Descriptor: Protein Nef, octyl beta-D-glucopyranoside
Authors:Wu, M, Augelli-Szafran, C.E, Ptak, R.G, Smithgall, T.E.
Deposit date:2017-10-03
Release date:2018-02-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A single beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.
PLoS ONE, 13, 2018
5HCK
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BU of 5hck by Molmil
HUMAN HCK SH3 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: HEMATOPOIETIC CELL KINASE
Authors:Horita, D.A, Baldisseri, D.M, Zhang, W, Altieri, A.S, Smithgall, T.E, Gmeiner, W.H, Byrd, R.A.
Deposit date:1998-03-09
Release date:1998-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human Hck SH3 domain and identification of its ligand binding site.
J.Mol.Biol., 278, 1998
3HCK
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BU of 3hck by Molmil
NMR ensemble of the uncomplexed human HCK SH2 domain, 20 structures
Descriptor: HCK SH2
Authors:Zhang, W, Smithgall, T.E, Gmeiner, W.H.
Deposit date:1997-03-31
Release date:1997-10-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.
FEBS Lett., 406, 1997
3NHN
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BU of 3nhn by Molmil
Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region
Descriptor: Tyrosine-protein kinase HCK
Authors:Alvarado, J.J, Betts, L, Moroco, J.A, Smithgall, T.E, Yeh, J.I.
Deposit date:2010-06-14
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism.
J.Biol.Chem., 285, 2010
4HCK
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BU of 4hck by Molmil
HUMAN HCK SH3 DOMAIN, NMR, 25 STRUCTURES
Descriptor: HEMATOPOIETIC CELL KINASE
Authors:Horita, D.A, Baldisseri, D.M, Zhang, W, Altieri, A.S, Smithgall, T.E, Gmeiner, W.H, Byrd, R.A.
Deposit date:1998-03-09
Release date:1998-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human Hck SH3 domain and identification of its ligand binding site.
J.Mol.Biol., 278, 1998
6C4S
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BU of 6c4s by Molmil
Human cSrc SH3 Domain in complex with Choline Kinase fragment 60-69
Descriptor: Proto-oncogene tyrosine-protein kinase Src,cSrc SH3 Domain, ZINC ION
Authors:Kall, S.L, Lavie, A.
Deposit date:2018-01-12
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase.
Sci Rep, 9, 2019
4E93
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BU of 4e93 by Molmil
Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684
Descriptor: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps
Authors:Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2012-03-20
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase.
Chem.Biol., 19, 2012

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