Author results

1QL6
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THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor:PHOSPHORYLASE KINASE, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Skamnaki, V.T., Owen, D.J., Noble, M.E.M., Lowe, E.D., Oikonomakos, N.G., Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999
4G9M
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CRYSTAL STRUCTURE OF THE RHIZOCTONIA SOLANI AGGLUTININ
Descriptor:agglutinin
Authors:Skamnaki, V.T., Kantsadi, A.L., Leonidas, D.D.
Deposit date:2012-07-24
Release date:2013-06-05
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural analysis of the Rhizoctonia solani agglutinin reveals a domain-swapping dimeric assembly.
Febs J., 280, 2013
4G9N
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CRYSTAL STRUCTURE OF THE RHIZOCTONIA SOLANI AGGLUTININ IN COMPLEX WITH N'-ACETYL-GALACTOSAMINE
Descriptor:agglutinin, 2-acetamido-2-deoxy-beta-D-galactopyranose
Authors:Skamnaki, V.T., Kantsadi, A.L., Leonidas, D.D.
Deposit date:2012-07-24
Release date:2013-06-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the Rhizoctonia solani agglutinin reveals a domain-swapping dimeric assembly.
Febs J., 280, 2013
3SYM
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH 3 -C-(HYDROXYMETHYL)-BETA-D-GLUCOPYRANONUCLEOSIDE OF 5-FLUOROURACIL
Descriptor:Glycogen phosphorylase, muscle form, 5-fluoro-1-[3-C-(hydroxymethyl)-beta-D-glucopyranosyl]pyrimidine-2,4(1H,3H)-dione
Authors:Skamnaki, V.T., Katsandi, A.L., Kontou, M., Leonidas, D.D.
Deposit date:2011-07-18
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:3'-Axial CH(2) OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why.
Chem.Biol.Drug Des., 79, 2012
3SYR
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH BETA-D-GLUCOPYRANONUCLEOSIDE 5-FLUOROURACIL
Descriptor:Glycogen phosphorylase, muscle form, 5-fluoro-1-(beta-D-glucopyranosyl)pyrimidine-2,4(1H,3H)-dione
Authors:Skamnaki, V.T., Kantsadi, A.L., Kontou, M., Leonidas, D.D.
Deposit date:2011-07-18
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:3'-Axial CH(2) OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why.
Chem.Biol.Drug Des., 79, 2012
1C50
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IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NOVEL ALLOSTERIC BINDING SITE OF GLYCOGEN PHOSPHORYLASE B
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE
Authors:Oikonomakos, N.G., Skamnaki, V.T., Tsitsanou, K.E., Gavalas, N.G., Johnson, L.N.
Deposit date:1999-12-15
Release date:1999-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A new allosteric site in glycogen phosphorylase b as a target for drug interactions.
Structure Fold.Des., 8, 2000
1C8K
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FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.
Deposit date:2000-05-11
Release date:2000-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
J.Biol.Chem., 275, 2000
1C8L
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SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, ...
Authors:Tsitsanou, K.E., Skamnaki, V.T., Oikonomakos, N.G.
Deposit date:2000-05-16
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug.
Arch.Biochem.Biophys., 384, 2000
1E1Y
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FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor:GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.
Deposit date:2000-05-11
Release date:2000-05-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site
J.Biol.Chem., 275, 2000
1GFZ
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FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor:GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, INOSINIC ACID, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.
Deposit date:2000-06-29
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
J.Biol.Chem., 275, 2000
2GPA
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ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), alpha-D-glucopyranose, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Tsitsanou, K.E., Zographos, S.E., Skamnaki, V.T.
Deposit date:1999-02-18
Release date:1999-02-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
Protein Sci., 8, 1999
3AMV
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ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), alpha-D-glucopyranose, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Tsitsanou, K.E., Zographos, S.E., Skamnaki, V.T.
Deposit date:1999-02-18
Release date:1999-02-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
Protein Sci., 8, 1999
1H5U
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THE 1.76 A RESOLUTION CRYSTAL STRUCTURE OF GLYCOGEN PHOSPHORYLASE B COMPLEXED WITH GLUCOSE AND CP320626, A POTENTIAL ANTIDIABETIC DRUG
Descriptor:GLYCOGEN PHOSPHORYLASE, 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE, alpha-D-glucopyranose, ...
Authors:Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Archontis, G.
Deposit date:2001-05-25
Release date:2001-06-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose, and Cp320626, a Potential Antidiabetic Drug
Bioorg.Med.Chem., 10, 2002
1B4D
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AMIDOCARBAMATE INHIBITOR OF GLYCOGEN PHOSPHORYLASE
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE B), 1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCO-2-HEPTULOPYRANOSONAMIDE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Tsitsanou, K.E., Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Gregoriou, M., Watson, K.A., Johnson, L.N., Fleet, G.W.J.
Deposit date:1998-12-18
Release date:1998-12-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
Protein Sci., 8, 1999
1BX3
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EFFECTS OF COMMONLY USED CRYOPROTECTANTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY AND STRUCTURE
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE B), PYRIDOXAL-5'-PHOSPHATE
Authors:Tsitsanou, K.E., Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Gregoriou, M., Watson, K.A., Johnson, L.N., Fleet, G.W.J.
Deposit date:1999-10-13
Release date:1999-10-21
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
Protein Sci., 8, 1999
1GGN
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STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:PROTEIN (GLYCOGEN PHOSPHORYLASE), BETA-D-GLUCOPYRANOSE SPIROHYDANTOIN, PYRIDOXAL-5'-PHOSPHATE
Authors:Watson, K.A., Tsitsanou, K.E., Gregoriou, M., Zographos, S.E., Skamnaki, V.T., Oikonomakos, N.G., Fleet, G.W., Johnson, L.N.
Deposit date:2000-08-29
Release date:2000-09-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B.
Bioorg.Med.Chem., 10, 2002
1GY3
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PCDK2/CYCLIN A IN COMPLEX WITH MGADP, NITRATE AND PEPTIDE SUBSTRATE
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, SUBSTRATE PEPTIDE, ...
Authors:Cook, A., Lowe, E.D., Chrysina, E.D., Skamnaki, V.T., Oikonomakos, N.G., Johnson, L.N.
Deposit date:2002-04-19
Release date:2002-04-29
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Studies on Phospho-Cdk2/Cyclin a Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism
Biochemistry, 41, 2002
1HLF
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BINDING OF GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUD
Descriptor:GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one
Authors:Oikonomakos, N.G., Skamnaki, V.T., Docsa, T., Toth, B., Gergely, P., Osz, E., Szilagyi, L., Somsak, L.
Deposit date:2000-12-01
Release date:2000-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B
BIOORG.MED.CHEM., 10, 2002
2PHK
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THE CRYSTAL STRUCTURE OF A PHOSPHORYLASE KINASE PEPTIDE SUBSTRATE COMPLEX: KINASE SUBSTRATE RECOGNITION
Descriptor:PHOSPHORYLASE KINASE, MC-PEPTIDE, MANGANESE (II) ION, ...
Authors:Lowe, E.D., Noble, M.E.M., Skamnaki, V.T., Oikonomakos, N.G., Owen, D.J., Johnson, L.N.
Deposit date:1998-06-18
Release date:1999-01-13
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
EMBO J., 16, 1997
3T3D
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH GLCU
Descriptor:Glycogen phosphorylase, muscle form, 1-beta-D-glucopyranosylpyrimidine-2,4(1H,3H)-dione
Authors:Kantsadi, A.L., Skamnaki, V.T., Leonidas, D.D.
Deposit date:2011-07-25
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase  b
Chemmedchem, 7, 2012
3T3E
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH GLCCLU
Descriptor:Glycogen phosphorylase, muscle form, 5-chloro-1-(beta-D-glucopyranosyl)pyrimidine-2,4(1H,3H)-dione
Authors:Kantsadi, A.L., Skamnaki, V.T., Leonidas, D.D.
Deposit date:2011-07-25
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase  b
Chemmedchem, 7, 2012
3T3G
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH GLCBRU
Descriptor:Glycogen phosphorylase, muscle form, 5-bromo-1-(beta-D-glucopyranosyl)pyrimidine-2,4(1H,3H)-dione
Authors:Kantsadi, A.L., Skamnaki, V.T., Leonidas, D.D.
Deposit date:2011-07-25
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase  b
Chemmedchem, 7, 2012
3T3H
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH GLCIU
Descriptor:Glycogen phosphorylase, muscle form, 1-(beta-D-glucopyranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Authors:Kantsadi, A.L., Skamnaki, V.T., Leonidas, D.D.
Deposit date:2011-07-25
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase  b
Chemmedchem, 7, 2012
3T3I
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH GLCCF3U
Descriptor:Glycogen phosphorylase, muscle form, 1-(beta-D-glucopyranosyl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione
Authors:Kantsadi, A.L., Skamnaki, V.T., Leonidas, D.D.
Deposit date:2011-07-25
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase  b
Chemmedchem, 7, 2012
4EJ2
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CRYSTAL STRUCTURE OF GPB IN COMPLEX WITH DK10
Descriptor:Glycogen phosphorylase, muscle form, 1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione
Authors:Kantsadi, A.L., Skamnaki, V.T., Leonidas, D.D.
Deposit date:2012-04-06
Release date:2012-07-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment.
Eur.J.Med.Chem., 54, 2012
171588
PDB entries from 2020-11-25