Author results

5LAE
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CRYSTAL STRUCTURE OF MURINE N1-ACETYLPOLYAMINE OXIDASE
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Sjogren, T., Aagaard, A., Snijder, A., Barlind, L.
Deposit date:2016-06-14
Release date:2017-03-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LFO
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CRYSTAL STRUCTURE OF MURINE N1-ACETYLPOLYAMINE OXIDASE IN COMPLEX WITH N1-ACETYLSPERMINE
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FLAVIN-ADENINE DINUCLEOTIDE, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, ...
Authors:Sjogren, T., Aagaard, A., Wassvik, C., Snijder, A., Barlind, L.
Deposit date:2016-07-04
Release date:2017-03-15
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LGB
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CRYSTAL STRUCTURE OF MURINE N1-ACETYLPOLYAMINE OXIDASE IN COMPLEX WITH MDL72527
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FAD-MDL72527 adduct, N,N'-BIS(2,3-BUTADIENYL)-1,4-BUTANE-DIAMINE
Authors:Sjogren, T., Aagaard, A., Wassvik, C., Snijder, A., Barlind, L.
Deposit date:2016-07-06
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5MBX
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CRYSTAL STRUCTURE OF REDUCED MURINE N1-ACETYLPOLYAMINE OXIDASE IN COMPLEX WITH N1-ACETYLSPERMINE
Descriptor:Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, FLAVIN-ADENINE DINUCLEOTIDE, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, ...
Authors:Sjogren, T., Aagaard, A., Wassvik, C., Snijder, A., Barlind, L.
Deposit date:2016-11-09
Release date:2017-01-18
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
1DY7
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CYTOCHROME CD1 NITRITE REDUCTASE, CO COMPLEX
Descriptor:NITRITE REDUCTASE, HEME D, CARBON MONOXIDE, ...
Authors:Sjogren, T., Svensson-Ek, M., Hajdu, J., Brzezinski, P.
Deposit date:2000-01-28
Release date:2000-09-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Proton-Coupled Structural Changes Upon Binding of Carbon Monoxide to Cytochrome Cd(1): A Combined Flash Photolysis and X-Ray Crystallography Study
Biochemistry, 39, 2000
1H9X
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CYTOCHROME CD1 NITRITE REDUCTASE, REDUCED FORM
Descriptor:CYTOCHROME CD1 NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Sjogren, T., Hajdu, J.
Deposit date:2001-03-23
Release date:2001-08-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structure of an Alternative Form of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase
J.Biol.Chem., 276, 2001
1H9Y
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CYTOCHROME CD1 NITRITE REDUCTASE, REDUCED FORM COMPLEXED TO CN
Descriptor:CYTOCHROME CD1 NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Sjogren, T., Hajdu, J.
Deposit date:2001-03-23
Release date:2001-08-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of an Alternative Form of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase
J.Biol.Chem., 276, 2001
1HCM
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CYTOCHROME CD1 NITRITE REDUCTASE, OXIDISED FROM FROM TETRAGONAL CRYSTALS
Descriptor:CYTOCHROME CD1 NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Sjogren, T., Hajdu, J.
Deposit date:2001-05-05
Release date:2001-08-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of an Alternative Form of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase
J.Biol.Chem., 276, 2001
1HJ3
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CYTOCHROME CD1 NITRITE REDUCTASE, DIOXYGEN COMPLEX
Descriptor:Nitrite reductase, HEME C, HEME D, ...
Authors:Sjogren, T., Hajdu, J.
Deposit date:2001-01-08
Release date:2001-01-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the bound dioxygen species in the cytochrome oxidase reaction of cytochrome cd1 nitrite reductase.
J. Biol. Chem., 276, 2001
1HJ4
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CYTOCHROME CD1 NITRITE REDUCTASE, X-RAY REDUCED DIOXYGEN COMPLEX
Descriptor:Nitrite reductase, HEME C, HEME D, ...
Authors:Sjogren, T., Hajdu, J.
Deposit date:2001-01-08
Release date:2001-01-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the bound dioxygen species in the cytochrome oxidase reaction of cytochrome cd1 nitrite reductase.
J. Biol. Chem., 276, 2001
1HJ5
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CYTOCHROME CD1 NITRITE REDUCTASE, REOXIDISED ENZYME
Descriptor:Nitrite reductase, HEME C, HEME D, ...
Authors:Sjogren, T., Hajdu, J.
Deposit date:2001-01-08
Release date:2001-01-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structure of the bound dioxygen species in the cytochrome oxidase reaction of cytochrome cd1 nitrite reductase.
J. Biol. Chem., 276, 2001
4AL0
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CRYSTAL STRUCTURE OF HUMAN PS-1
Descriptor:PROSTAGLANDIN E SYNTHASE, GLUTATHIONE, PALMITIC ACID, ...
Authors:Sjogren, T., Nord, J., Ek, M., Johansson, P., Liu, G., Geschwindner, S.
Deposit date:2012-02-29
Release date:2013-02-06
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Crystal Structure of Microsomal Prostaglandin E2 Synthase Provides Insight Into Diversity in the Mapeg Superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
4AL1
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CRYSTAL STRUCTURE OF HUMAN PS-1 GSH-ANALOG COMPLEX
Descriptor:PROSTAGLANDIN E SYNTHASE, B-OCTYLGLUCOSIDE, PALMITIC ACID, ...
Authors:Sjogren, T., Nord, J., Ek, M., Johansson, P., Liu, G., Geschwindner, S.
Deposit date:2012-02-29
Release date:2013-02-06
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Microsomal Prostaglandin E2 Synthase Provides Insight Into Diversity in the Mapeg Superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
1GQ1
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CYTOCHROME CD1 NITRITE REDUCTASE, Y25S MUTANT, OXIDISED FORM
Descriptor:CYTOCHROME CD1 NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Sjogren, T., Gordon, E.H.J., Lofqvist, M., Richter, C.D., Hajdu, J., Ferguson, S.J.
Deposit date:2001-11-19
Release date:2002-11-28
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and Kinetic Properties of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase with the D1 Heme Active Site Ligand Tyrosine 25 Replaced by Serine
J.Biol.Chem., 278, 2003
2J0D
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CRYSTAL STRUCTURE OF HUMAN P450 3A4 IN COMPLEX WITH ERYTHROMYCIN
Descriptor:CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, ERYTHROMYCIN A
Authors:Sjogren, T., Ekroos, M.
Deposit date:2006-08-02
Release date:2006-09-04
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4
Proc.Natl.Acad.Sci.USA, 103, 2006
2V0M
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CRYSTAL STRUCTURE OF HUMAN P450 3A4 IN COMPLEX WITH KETOCONAZOLE
Descriptor:CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE
Authors:Sjogren, T., Ekroos, M.
Deposit date:2007-05-15
Release date:2007-06-26
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4
Proc.Natl.Acad.Sci.USA, 103, 2006
5ALB
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TICAGRELOR ANTIDOTE CANDIDATE MEDI2452 IN COMPLEX WITH TICAGRELOR
Descriptor:MEDI2452 HEAVY CHAIN, MEDI2452 LIGHT CHAIN, Ticagrelor
Authors:Buchanan, A., Newton, P., Pehrsson, S., Inghardt, T., Antonsson, T., Svensson, P., Sjogren, T., Oster, L., Janefeldt, A., Sandinge, A., Keyes, F., Austin, M., Spooner, J., Penney, M., Howells, G., Vaughan, T., Nylander, S.
Deposit date:2015-03-07
Release date:2015-04-01
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural and Functional Characterisation of a Specific Antidote for Ticagrelor.
Blood, 125, 2015
5ALC
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TICAGRELOR ANTIDOTE CANDIDATE FAB 72 IN COMPLEX WITH TICAGRELOR
Descriptor:ANTI-TICAGRELOR FAB 72, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Buchanan, A., Newton, P., Pehrsson, S., Inghardt, T., Antonsson, T., Svensson, P., Sjogren, T., Oster, L., Janefeldt, A., Sandinge, A., Keyes, F., Austin, M., Spooner, J., Penney, M., Howells, G., Vaughan, T., Nylander, S.
Deposit date:2015-03-07
Release date:2015-04-01
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Functional Characterisation of a Specific Antidote for Ticagrelor.
Blood, 125, 2015
4AOJ
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HUMAN TRKA IN COMPLEX WITH THE INHIBITOR AZ-23
Descriptor:HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, ZINC ION
Authors:Wang, T., Lamb, M.L., Block, M.H., Davies, A.M., Han, Y., Hoffmann, E., Ioannidis, S., Josey, J.A., Liu, Z., Lyne, P.D., MacIntyre, T., Mohr, P.J., Omer, C.A., Sjogren, T., Thress, K., Wang, B., Wang, H., Yu, D., Zhang, H.
Deposit date:2012-03-28
Release date:2012-08-15
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors
Acs Med.Chem.Lett., 3, 2012
4UV4
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CRYSTAL STRUCTURE OF ANTI-FPR FPRO0165 FAB FRAGMENT
Descriptor:FPRO0165 FAB
Authors:Douthwaite, J.A., Sridharan, S., Huntington, C., Marwood, R., Hammersley, J., Hakulinen, J.K., Ek, M., Sjogren, T., Rider, D., Privezentzev, C., Seaman, J.C., Cariuk, P., Knights, V., Young, J., Wilkinson, T., Sleeman, M., Finch, D.K., Lowe, D.C., Vaughan, T.J.
Deposit date:2014-08-04
Release date:2014-12-24
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Affinity Maturation of a Novel Antagonistic Human Monoclonal Antibody with a Long Vh Cdr3 Targeting the Class a Gpcr Formyl-Peptide Receptor 1.
Mabs, 7, 2015
3ZS0
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HUMAN MYELOPEROXIDASE INACTIVATED BY TX2
Descriptor:MYELOPEROXIDASE LIGHT CHAIN, MYELOPEROXIDASE HEAVY CHAIN, SULFATE ION, ...
Authors:Tiden, A.K., Sjogren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchere, F., Norman, H., Markgren, P.O., Gustavsson, S., Schmidt, S., Lundquist, S., Forbes, L.V., Magon, N.J., Jameson, G.N., Eriksson, H., Kettle, A.J.
Deposit date:2011-06-21
Release date:2011-08-31
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.
J.Biol.Chem., 286, 2011
3ZS1
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HUMAN MYELOPEROXIDASE INACTIVATED BY TX5
Descriptor:MYELOPEROXIDASE LIGHT CHAIN, MYELOPEROXIDASE HEAVY CHAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Tiden, A.K., Sjogren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchere, F., Norman, H., Markgren, P.O., Gustavsson, S., Schmidt, S., Lundquist, S., Forbes, L.V., Magon, N.J., Jameson, G.N., Eriksson, H., Kettle, A.J.
Deposit date:2011-06-21
Release date:2011-08-31
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.
J.Biol.Chem., 286, 2011
4AQH
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PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH THE INHIBITOR AZ3976
Descriptor:PLASMINOGEN ACTIVATOR INHIBITOR 1, TERT-BUTYL 3-[(4-OXO-3H-PYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]AZETIDINE-1-CARBOXYLATE
Authors:Fjellstrom, O., Deinum, J., Sjogren, T., Johansson, C., Geschwindner, S., Nerme, V., Legnehed, A., McPheat, J., Olsson, K., Bodin, C., Gustafsson, D.
Deposit date:2012-04-17
Release date:2012-11-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation
J.Biol.Chem., 288, 2013
4C1M
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MYELOPEROXIDASE IN COMPLEX WITH THE REVESIBLE INHIBITOR HX1
Descriptor:MYELOPEROXIDASE LIGHT CHAIN, MYELOPEROXIDASE HEAVY CHAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Forbes, L.V., Sjogren, T., Auchere, F., Jenkins, D.W., Thong, B., Laughton, D., Hemsley, P., Pairaudeau, G., Eriksson, H., Unitt, J.F., Kettle, A.J.
Deposit date:2013-08-13
Release date:2013-11-13
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates
J.Biol.Chem., 288, 2013
4C7J
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11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR
Descriptor:CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-cyclopropyl-2-(2-hydroxyethyloxy)-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-1,3-thiazole-5-carboxamide
Authors:Goldberg, F.W., Dossetter, A.G., Scott, J.S., Robb, G.R., Boyd, S., Groombridge, S.D., Kemmitt, P.D., Sjogren, T., Morentin Gutierrez, P., de Schoolmeester, J., Swales, J.G., Turnbull, A.V., Wild, M.J.
Deposit date:2013-09-23
Release date:2014-09-03
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice.
J.Med.Chem., 57, 2014
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