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1DY7
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BU of 1dy7 by Molmil
Cytochrome cd1 Nitrite Reductase, CO complex
Descriptor: CARBON MONOXIDE, GLYCEROL, HEME C, ...
Authors:Sjogren, T, Svensson-Ek, M, Hajdu, J, Brzezinski, P.
Deposit date:2000-01-28
Release date:2000-09-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Proton-Coupled Structural Changes Upon Binding of Carbon Monoxide to Cytochrome Cd(1): A Combined Flash Photolysis and X-Ray Crystallography Study
Biochemistry, 39, 2000
5LAE
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BU of 5lae by Molmil
Crystal structure of murine N1-acetylpolyamine oxidase
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Authors:Sjogren, T, Aagaard, A, Snijder, A, Barlind, L.
Deposit date:2016-06-14
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LFO
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BU of 5lfo by Molmil
Crystal structure of murine N1-acetylpolyamine oxidase in complex with N1-acetylspermine
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, ...
Authors:Sjogren, T, Aagaard, A, Wassvik, C, Snijder, A, Barlind, L.
Deposit date:2016-07-04
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5LGB
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BU of 5lgb by Molmil
Crystal structure of murine N1-acetylpolyamine oxidase in complex with MDL72527
Descriptor: FAD-MDL72527 adduct, N,N'-BIS(2,3-BUTADIENYL)-1,4-BUTANE-DIAMINE, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase,Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Authors:Sjogren, T, Aagaard, A, Wassvik, C, Snijder, A, Barlind, L.
Deposit date:2016-07-06
Release date:2017-08-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
5MBX
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BU of 5mbx by Molmil
Crystal structure of reduced murine N1-acetylpolyamine oxidase in complex with N1-acetylspermine
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, ...
Authors:Sjogren, T, Aagaard, A, Wassvik, C, Snijder, A, Barlind, L.
Deposit date:2016-11-09
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Structure of Murine N(1)-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.
Biochemistry, 56, 2017
1H9X
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BU of 1h9x by Molmil
Cytochrome cd1 Nitrite Reductase, reduced form
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CYTOCHROME CD1 NITRITE REDUCTASE, HEME C, ...
Authors:Sjogren, T, Hajdu, J.
Deposit date:2001-03-23
Release date:2001-08-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structure of an Alternative Form of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase
J.Biol.Chem., 276, 2001
1HCM
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BU of 1hcm by Molmil
Cytochrome cd1 Nitrite Reductase, oxidised from from tetragonal crystals
Descriptor: CYTOCHROME CD1 NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Sjogren, T, Hajdu, J.
Deposit date:2001-05-05
Release date:2001-08-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of an Alternative Form of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase
J.Biol.Chem., 276, 2001
1H9Y
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BU of 1h9y by Molmil
Cytochrome cd1 Nitrite Reductase, reduced form complexed to CN
Descriptor: CYANIDE ION, CYTOCHROME CD1 NITRITE REDUCTASE, HEME C, ...
Authors:Sjogren, T, Hajdu, J.
Deposit date:2001-03-23
Release date:2001-08-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of an Alternative Form of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase
J.Biol.Chem., 276, 2001
1HJ3
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BU of 1hj3 by Molmil
Cytochrome cd1 Nitrite Reductase, dioxygen complex
Descriptor: GLYCEROL, HEME C, HEME D, ...
Authors:Sjogren, T, Hajdu, J.
Deposit date:2001-01-08
Release date:2001-01-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the bound dioxygen species in the cytochrome oxidase reaction of cytochrome cd1 nitrite reductase.
J. Biol. Chem., 276, 2001
1HJ5
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BU of 1hj5 by Molmil
Cytochrome cd1 Nitrite Reductase, reoxidised enzyme
Descriptor: GLYCEROL, HEME C, HEME D, ...
Authors:Sjogren, T, Hajdu, J.
Deposit date:2001-01-08
Release date:2001-01-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structure of the bound dioxygen species in the cytochrome oxidase reaction of cytochrome cd1 nitrite reductase.
J. Biol. Chem., 276, 2001
1HJ4
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BU of 1hj4 by Molmil
Cytochrome cd1 Nitrite Reductase, x-ray reduced dioxygen complex
Descriptor: GLYCEROL, HEME C, HEME D, ...
Authors:Sjogren, T, Hajdu, J.
Deposit date:2001-01-08
Release date:2001-01-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the bound dioxygen species in the cytochrome oxidase reaction of cytochrome cd1 nitrite reductase.
J. Biol. Chem., 276, 2001
4AL0
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BU of 4al0 by Molmil
Crystal structure of Human PS-1
Descriptor: GLUTATHIONE, PALMITIC ACID, PROSTAGLANDIN E SYNTHASE, ...
Authors:Sjogren, T, Nord, J, Ek, M, Johansson, P, Liu, G, Geschwindner, S.
Deposit date:2012-02-29
Release date:2013-02-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Crystal Structure of Microsomal Prostaglandin E2 Synthase Provides Insight Into Diversity in the Mapeg Superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
4AL1
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BU of 4al1 by Molmil
Crystal structure of Human PS-1 GSH-analog complex
Descriptor: L-gamma-glutamyl-S-(2-biphenyl-4-yl-2-oxoethyl)-L-cysteinylglycine, PALMITIC ACID, PROSTAGLANDIN E SYNTHASE, ...
Authors:Sjogren, T, Nord, J, Ek, M, Johansson, P, Liu, G, Geschwindner, S.
Deposit date:2012-02-29
Release date:2013-02-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Microsomal Prostaglandin E2 Synthase Provides Insight Into Diversity in the Mapeg Superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
7NI1
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BU of 7ni1 by Molmil
CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 9
Descriptor: (S)-1-(2-(amino(phenyl)methyl)benzyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Sjogren, T, Inghardt, T.
Deposit date:2021-02-11
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
J.Med.Chem., 65, 2022
7NI3
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BU of 7ni3 by Molmil
CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-sulfanylidene-3-[(2R)-tetrahydro-2-furanylmethyl]-1,2,3,7-tetrahydro-6H-purin-6-one, CALCIUM ION, ...
Authors:Sjogren, T, Inghardt, T.
Deposit date:2021-02-11
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
J.Med.Chem., 65, 2022
2V0M
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BU of 2v0m by Molmil
Crystal structure of human P450 3A4 in complex with ketoconazole
Descriptor: 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE, CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sjogren, T, Ekroos, M.
Deposit date:2007-05-15
Release date:2007-06-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4
Proc.Natl.Acad.Sci.USA, 103, 2006
2J0D
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BU of 2j0d by Molmil
Crystal structure of human P450 3A4 in complex with erythromycin
Descriptor: CYTOCHROME P450 3A4, ERYTHROMYCIN A, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sjogren, T, Ekroos, M.
Deposit date:2006-08-02
Release date:2006-09-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4
Proc.Natl.Acad.Sci.USA, 103, 2006
1GQ1
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BU of 1gq1 by Molmil
CYTOCHROME CD1 NITRITE REDUCTASE, Y25S mutant, OXIDISED FORM
Descriptor: CYTOCHROME CD1 NITRITE REDUCTASE, GLYCEROL, HEME C, ...
Authors:Sjogren, T, Gordon, E.H.J, Lofqvist, M, Richter, C.D, Hajdu, J, Ferguson, S.J.
Deposit date:2001-11-19
Release date:2002-11-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and Kinetic Properties of Paracoccus Pantotrophus Cytochrome Cd1 Nitrite Reductase with the D1 Heme Active Site Ligand Tyrosine 25 Replaced by Serine
J.Biol.Chem., 278, 2003
4UV4
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BU of 4uv4 by Molmil
Crystal structure of anti-FPR Fpro0165 Fab fragment
Descriptor: FPRO0165 FAB
Authors:Douthwaite, J.A, Sridharan, S, Huntington, C, Marwood, R, Hammersley, J, Hakulinen, J.K, Ek, M, Sjogren, T, Rider, D, Privezentzev, C, Seaman, J.C, Cariuk, P, Knights, V, Young, J, Wilkinson, T, Sleeman, M, Finch, D.K, Lowe, D.C, Vaughan, T.J.
Deposit date:2014-08-04
Release date:2014-12-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Affinity Maturation of a Novel Antagonistic Human Monoclonal Antibody with a Long Vh Cdr3 Targeting the Class a Gpcr Formyl-Peptide Receptor 1.
Mabs, 7, 2015
5ALB
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BU of 5alb by Molmil
Ticagrelor antidote candidate MEDI2452 in complex with ticagrelor
Descriptor: MEDI2452 HEAVY CHAIN, MEDI2452 LIGHT CHAIN, Ticagrelor
Authors:Buchanan, A, Newton, P, Pehrsson, S, Inghardt, T, Antonsson, T, Svensson, P, Sjogren, T, Oster, L, Janefeldt, A, Sandinge, A, Keyes, F, Austin, M, Spooner, J, Penney, M, Howells, G, Vaughan, T, Nylander, S.
Deposit date:2015-03-07
Release date:2015-04-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural and Functional Characterisation of a Specific Antidote for Ticagrelor.
Blood, 125, 2015
5ALC
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BU of 5alc by Molmil
Ticagrelor antidote candidate Fab 72 in complex with ticagrelor
Descriptor: ANTI-TICAGRELOR FAB 72, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Buchanan, A, Newton, P, Pehrsson, S, Inghardt, T, Antonsson, T, Svensson, P, Sjogren, T, Oster, L, Janefeldt, A, Sandinge, A, Keyes, F, Austin, M, Spooner, J, Penney, M, Howells, G, Vaughan, T, Nylander, S.
Deposit date:2015-03-07
Release date:2015-04-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Functional Characterisation of a Specific Antidote for Ticagrelor.
Blood, 125, 2015
4AOJ
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BU of 4aoj by Molmil
Human TrkA in complex with the inhibitor AZ-23
Descriptor: 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, ZINC ION
Authors:Wang, T, Lamb, M.L, Block, M.H, Davies, A.M, Han, Y, Hoffmann, E, Ioannidis, S, Josey, J.A, Liu, Z, Lyne, P.D, MacIntyre, T, Mohr, P.J, Omer, C.A, Sjogren, T, Thress, K, Wang, B, Wang, H, Yu, D, Zhang, H.
Deposit date:2012-03-28
Release date:2012-08-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors
Acs Med.Chem.Lett., 3, 2012
4NZ2
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BU of 4nz2 by Molmil
Crystal structure of CYP2C9 in complex with an inhibitor
Descriptor: (2R)-N-{4-[(3-bromophenyl)sulfonyl]-2-chlorophenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide, Cytochrome P450 2C9, GLYCEROL, ...
Authors:Branden, G, Sjogren, T, Xue, Y.
Deposit date:2013-12-11
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure-based ligand design to overcome CYP inhibition in drug discovery projects.
Drug Discov Today, 19, 2014
4NY4
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BU of 4ny4 by Molmil
Crystal structure of CYP3A4 in complex with an inhibitor
Descriptor: (8R)-3,3-difluoro-8-[4-fluoro-3-(pyridin-3-yl)phenyl]-8-(4-methoxy-3-methylphenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
Authors:Branden, G, Sjogren, T, Xue, Y.
Deposit date:2013-12-10
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure-based ligand design to overcome CYP inhibition in drug discovery projects.
Drug Discov Today, 19, 2014
3ZS0
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BU of 3zs0 by Molmil
Human Myeloperoxidase inactivated by TX2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(4-FLUOROBENZYL)-2-THIOXO-1,2,3,7-TETRAHYDRO-6H-PURIN-6-ONE, ACETATE ION, ...
Authors:Tiden, A.K, Sjogren, T, Svensson, M, Bernlind, A, Senthilmohan, R, Auchere, F, Norman, H, Markgren, P.O, Gustavsson, S, Schmidt, S, Lundquist, S, Forbes, L.V, Magon, N.J, Jameson, G.N, Eriksson, H, Kettle, A.J.
Deposit date:2011-06-21
Release date:2011-08-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.
J.Biol.Chem., 286, 2011

 

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