Author results

1QU2
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, POTASSIUM ION, ...
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1QU3
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, ZINC ION, ...
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1FFY
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor:ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, POTASSIUM ION, ...
Authors:Silvian, L.F., Wang, J., Steitz, T.A.
Deposit date:2000-07-26
Release date:2000-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1K1Q
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CRYSTAL STRUCTURE OF A DINB FAMILY ERROR PRONE DNA POLYMERASE FROM SULFOLOBUS SOLFATARICUS
Descriptor:DBH protein
Authors:Silvian, L.F., Toth, E.A., Pham, P., Goodman, M.F., Ellenberger, T.
Deposit date:2001-09-25
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
Nat.Struct.Biol., 8, 2001
1K1S
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CRYSTAL STRUCTURE OF DINB FROM SULFOLOBUS SOLFATARICUS
Descriptor:DBH protein
Authors:Silvian, L.F., Toth, E.A., Pham, P., Goodman, M.F., Ellenberger, T.
Deposit date:2001-09-25
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
Nat.Struct.Biol., 8, 2001
3LKJ
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SMALL MOLECULE INHIBITION OF THE TNF FAMILY CYOKINE CD40 LIGAND THROUGH A SUBUNIT FRACTURE MECHANISM
Descriptor:CD40 ligand, N-ACETYL-D-GLUCOSAMINE, (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid
Authors:Silvian, L.F., Whitty, A.
Deposit date:2010-01-27
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism.
Acs Chem.Biol., 6, 2011
5J5T
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GLK CO-CRYSTAL STRUCTURE WITH AMINOPYRROLOPYRIMIDINE INHIBITOR
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 3, 5-[2-(piperidin-4-yl)-1,3-thiazol-5-yl]-3-[(pyridin-4-yl)methoxy]pyridin-2-amine
Authors:Silvian, L.F., Marcotte, D.
Deposit date:2016-04-03
Release date:2016-10-26
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Protein Sci., 26, 2017
1QTQ
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GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNA AND AN AMINO ACID ANALOG
Descriptor:RNA (TRNA GLN II ), PROTEIN (GLUTAMINYL-TRNA SYNTHETASE), SULFATE ION, ...
Authors:Rath, V.L., Silvian, L.F., Beijer, B., Sproat, B.S., Steitz, T.A.
Deposit date:1998-01-28
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:How glutaminyl-tRNA synthetase selects glutamine.
Structure, 6, 1998
3GEN
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THE 1.6 A CRYSTAL STRUCTURE OF HUMAN BRUTON'S TYROSINE KINASE BOUND TO A PYRROLOPYRIMIDINE-CONTAINING COMPOUND
Descriptor:Tyrosine-protein kinase BTK, 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane
Authors:Marcotte, D.J., Liu, Y.T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.
Deposit date:2009-02-25
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Protein Sci., 19, 2010
3K54
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STRUCTURES OF HUMAN BRUTON'S TYROSINE KINASE IN ACTIVE AND INACTIVE CONFORMATIONS SUGGESTS A MECHANISM OF ACTIVATION FOR TEC FAMILY KINASES.
Descriptor:Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
Authors:Marcotte, D.J., Liu, Y.-T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B.T., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.
Deposit date:2009-10-06
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Protein Sci., 19, 2010
3BQM
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LFA-1 I DOMAIN BOUND TO INHIBITORS
Descriptor:Integrin alpha-L, 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Authors:Silvian, L.F.
Deposit date:2007-12-20
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3BQN
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LFA-1 I DOMAIN BOUND TO INHIBITORS
Descriptor:Integrin alpha-L, 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfanyl}-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl}morpholine
Authors:Silvian, L.F.
Deposit date:2007-12-20
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3BRT
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NEMO/IKK ASSOCIATION DOMAIN STRUCTURE
Descriptor:Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha, NF-kappa-B essential modulator
Authors:Silvian, L.F.
Deposit date:2007-12-21
Release date:2008-04-22
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site.
Structure, 16, 2008
3BRV
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NEMO/IKKB ASSOCIATION DOMAIN STRUCTURE
Descriptor:Inhibitor of nuclear factor kappa-B kinase subunit beta, NF-kappa-B essential modulator
Authors:Silvian, L.F.
Deposit date:2007-12-21
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site.
Structure, 16, 2008
3E2M
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LFA-1 I DOMAIN BOUND TO INHIBITORS
Descriptor:Integrin alpha-L, cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)phenoxy]methyl}cyclohexanecarboxylic acid
Authors:Silvian, L.F.
Deposit date:2008-08-05
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3KJ4
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STRUCTURE OF RAT NOGO RECEPTOR BOUND TO 1D9 ANTAGONIST ANTIBODY
Descriptor:Fab fragment 1D9 light chain, Fab fragment 1D9 heavy chain, Reticulon-4 receptor, ...
Authors:Silvian, L.F.
Deposit date:2009-11-02
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering.
Biotechnol Appl Biochem, 57, 2010
3KYK
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CRYSTAL STRUCTURE OF LI33 IGG1 FAB
Descriptor:Heavy Chain Li33 IgG1, Light Chain Li33 IgG1, SULFATE ION
Authors:Silvian, L.F., Pepinsky, R.B., Walus, L.
Deposit date:2009-12-06
Release date:2010-03-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.
Protein Sci., 19, 2010
3KYM
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CRYSTAL STRUCTURE OF LI33 IGG2 DI-FAB
Descriptor:Light Chain Li33 IgG2, Heavy Chain Li33 IgG2
Authors:Silvian, L.F., Pepinsky, R.B., Walus, L.
Deposit date:2009-12-06
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.
Protein Sci., 19, 2010
4X7Q
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PIM2 KINASE IN COMPLEX WITH COMPOUND 1S
Descriptor:Serine/threonine-protein kinase pim-2, 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, PHOSPHATE ION
Authors:Marcotte, D.J., Silvian, L.F.
Deposit date:2014-12-09
Release date:2015-02-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
4XHK
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PIM1 KINASE IN COMPLEX WITH COMPOUND 1S
Descriptor:Serine/threonine-protein kinase pim-1, 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide
Authors:Marcotte, D.J., Silvian, L.F.
Deposit date:2015-01-05
Release date:2015-02-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
3M1N
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CRYSTAL STRUCTURE OF HUMAN SONIC HEDGEHOG N-TERMINAL DOMAIN
Descriptor:Sonic hedgehog protein, ZINC ION, SULFATE ION
Authors:Boriack-Sjodin, P.A., Pepinsky, R.B., Garber, E.A., Silvian, L.F.
Deposit date:2010-03-05
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mapping sonic hedgehog-receptor interactions by steric interference.
J.Biol.Chem., 275, 2000
5IXK
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RORGAMMA IN COMPLEX WITH INVERSE AGONIST BIO399.
Descriptor:Nuclear receptor ROR-gamma, N-(5-ethyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide
Authors:Marcotte, D.J.
Deposit date:2016-03-23
Release date:2016-06-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
Bmc Struct.Biol., 16, 2016
5IZ0
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RORGAMMA IN COMPLEX WITH AGONIST BIO592 AND COACTIVATOR EBI96
Descriptor:Nuclear receptor ROR-gamma, GLU-PHE-PRO-TYR-LEU-LEU-SER-LEU-LEU-GLY-GLU-VAL-SER-PRO-GLN, N-(4-ethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide, ...
Authors:Marcotte, D.J.
Deposit date:2016-03-24
Release date:2016-06-15
Method:X-RAY DIFFRACTION (2.635 Å)
Cite:Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
Bmc Struct.Biol., 16, 2016
5KNJ
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PSEUDOKINASE DOMAIN OF MLKL BOUND TO COMPOUND 1.
Descriptor:Mixed lineage kinase domain-like protein, 1-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethyloxy)phenyl]urea
Authors:Marcotte, D.J.
Deposit date:2016-06-28
Release date:2016-11-16
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
Plos One, 11, 2016
5KO1
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PSEUDOKINASE DOMAIN OF MLKL BOUND TO COMPOUND 4.
Descriptor:Mixed lineage kinase domain-like protein, [(1~{R})-2-[(4-fluorophenyl)amino]-2-oxidanylidene-1-phenyl-ethyl] 3-azanylpyrazine-2-carboxylate
Authors:Marcotte, D.J.
Deposit date:2016-06-29
Release date:2016-11-16
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
Plos One, 11, 2016
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