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2OM2
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BU of 2om2 by Molmil
Crystal Structure Of Human G[alpha]i1 Bound To The Goloco Motif Of Rgs14
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Siderovski, D.P, Kimple, R.J.
Deposit date:2007-01-20
Release date:2007-07-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities.
J.Mol.Biol., 371, 2007
2XNS
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BU of 2xns by Molmil
Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14
Descriptor: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, GUANOSINE-5'-DIPHOSPHATE, REGULATOR OF G-PROTEIN SIGNALING 14, ...
Authors:Bosch, D, Sammond, D.W, Butterfoss, G.L, Machius, M, Siderovski, D.P, Kuhlman, B.
Deposit date:2010-08-05
Release date:2011-06-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Computational Design of the Sequence and Structure of a Protein-Binding Peptide.
J.Am.Chem.Soc., 133, 2011
3ONW
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BU of 3onw by Molmil
Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, ...
Authors:Bosch, D, Kimple, A.J, Sammond, D.W, Miley, M.J, Machius, M, Kuhlman, B, Willard, F.S, Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
3QI2
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BU of 3qi2 by Molmil
A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
Descriptor: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Bosch, D.E, Willard, F.S, Kimple, A.J, Miley, M.J, Siderovski, D.P.
Deposit date:2011-01-26
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
4DVG
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BU of 4dvg by Molmil
Crystal structure of E. histolytica Formin1 bound to EhRho1-GTPgammaS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Diaphanous protein, MAGNESIUM ION, ...
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-02-23
Release date:2012-11-14
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Entamoeba histolytica Rho1 Regulates Actin Polymerization through a Divergent, Diaphanous-Related Formin.
Biochemistry, 51, 2012
1Y3A
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BU of 1y3a by Molmil
Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Johnston, C.A, Willard, F.S, Jezyk, M.R, Fredericks, Z, Bodor, E.T, Jones, M.B, Blaesius, R, Harden, T.K, Sondek, J, Watts, V.J, Ramer, J.K, Siderovski, D.P.
Deposit date:2004-11-24
Release date:2005-07-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
3QE0
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BU of 3qe0 by Molmil
A Galpha-i1 P-loop mutation prevents transition to the activated state
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, ...
Authors:Bosch, D.E, Willard, F.S, Kimple, A.J, Miley, M.J, Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3UMS
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BU of 3ums by Molmil
Crystal structure of the G202A mutant of human G-alpha-i1
Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Lambert, N.A, Johnston, C.A, Cappell, S.D, Kuravi, S, Kimple, A.J, Willard, F.S, Siderovski, D.P.
Deposit date:2011-11-14
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
4MIT
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BU of 4mit by Molmil
Crystal structure of E. histolytica RacC bound to the EhPAK4 PBD
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho family GTPase, ...
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2013-09-02
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors.
Biochemistry, 54, 2015
3REG
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BU of 3reg by Molmil
Crystal structure of EhRho1 bound to a GTP analog and Magnesium
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho-like small GTPase
Authors:Bosch, D.E, Qiu, C, Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
3REF
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BU of 3ref by Molmil
Crystal structure of EhRho1 bound to GDP and Magnesium
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho-like small GTPase, ...
Authors:Bosch, D.E, Qiu, C, Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
3UMR
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BU of 3umr by Molmil
Crystal structure of the G202D mutant of human G-alpha-i1
Descriptor: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Johnston, C.A, Afshar, K, Snyder, J.T, Tall, G.G, Gonczy, P, Siderovski, D.P, Willard, F.S.
Deposit date:2011-11-14
Release date:2012-10-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans
To be Published
2PBI
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BU of 2pbi by Molmil
The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure
Descriptor: GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9
Authors:Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
4FID
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BU of 4fid by Molmil
Crystal structure of a heterotrimeric G-Protein subunit from entamoeba histolytica, EHG-ALPHA-1
Descriptor: G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE
Authors:Bosch, D.E, Kimple, A.J, Muller, R.E, Gigure, P.M, Willard, F.S, Machius, M, Temple, B.R, Siderovski, D.P.
Deposit date:2012-06-08
Release date:2012-11-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.
Plos Pathog., 8, 2012
4GPR
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BU of 4gpr by Molmil
Crystal structure of EhUbc5, a ubiquitin conjugating enzyme from Entamoeba histolytica
Descriptor: COBALT (II) ION, Ubiquitin-conjugating enzyme family protein
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-08-21
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GU2
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BU of 4gu2 by Molmil
Crystal structure of ubiquitin from Entamoeba histolytica to 1.35 Angstrom
Descriptor: Ubiquitin
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-08-29
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GOU
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BU of 4gou by Molmil
Crystal structure of an RGS-RhoGEF from Entamoeba histolytica
Descriptor: EhRGS-RhoGEF
Authors:Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P.
Deposit date:2012-08-20
Release date:2013-01-09
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.
Structure, 21, 2013
4GSW
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BU of 4gsw by Molmil
Crystal structure of ubiquitin from Entamoeba histolytica to 2.15 Angstrom
Descriptor: SULFATE ION, Ubiquitin
Authors:Bosch, D.E, Siderovski, D.P.
Deposit date:2012-08-28
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
2G83
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BU of 2g83 by Molmil
Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Johnston, C.A, Ramer, J.K, Blaesius, R, Kuhlman, B, Arshavsky, V.Y, Siderovski, D.P.
Deposit date:2006-03-01
Release date:2006-10-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer.
Biochemistry, 45, 2006
1IHJ
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BU of 1ihj by Molmil
Crystal Structure of the N-terminal PDZ domain of InaD in complex with a NorpA C-terminal peptide
Descriptor: InaD, phospholipase C
Authors:Kimple, M.E, Siderovski, D.P, Sondek, J.
Deposit date:2001-04-19
Release date:2001-08-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
EMBO J., 20, 2001
1KJY
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BU of 1kjy by Molmil
Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14
Descriptor: CESIUM ION, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT, ...
Authors:Kimple, R.J, Kimple, M.E, Betts, L, Sondek, J, Siderovski, D.P.
Deposit date:2001-12-05
Release date:2002-05-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature, 416, 2002
1KZ7
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BU of 1kz7 by Molmil
Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42
Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1KZG
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BU of 1kzg by Molmil
DbsCdc42(Y889F)
Descriptor: CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Authors:Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1LB1
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BU of 1lb1 by Molmil
Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA
Descriptor: Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
3D7M
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BU of 3d7m by Molmil
Crystal Structure of the G Protein Fast-Exchange Double Mutant I56C/Q333C
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Funk, M.A, Preininger, A.M, Oldham, W.M, Meier, S.M, Hamm, H.E, Iverson, T.M.
Deposit date:2008-05-21
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry, 48, 2009

 

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