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2OM2
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CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signalling 14 GoLoco motif peptide, ...
Authors:Siderovski, D.P., Kimple, R.J.
Deposit date:2007-01-20
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities.
J.Mol.Biol., 371, 2007
2XNS
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CRYSTAL STRUCTURE OF HUMAN G ALPHA I1 BOUND TO A DESIGNED HELICAL PEPTIDE DERIVED FROM THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, REGULATOR OF G-PROTEIN SIGNALING 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Sammond, D.W., Butterfoss, G.L., Machius, M., Siderovski, D.P., Kuhlman, B.
Deposit date:2010-08-05
Release date:2011-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Computational Design of the Sequence and Structure of a Protein-Binding Peptide.
J.Am.Chem.Soc., 133, 2011
3ONW
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STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR THE RGS14 GOLOCO MOTIF.
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Kimple, A.J., Sammond, D.W., Miley, M.J., Machius, M., Kuhlman, B., Willard, F.S., Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
3QI2
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A GALPHA P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE: G42R BOUND TO RGS14 GOLOCO
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-26
Release date:2012-02-01
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3QE0
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A GALPHA-I1 P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3UMS
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CRYSTAL STRUCTURE OF THE G202A MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Lambert, N.A., Johnston, C.A., Cappell, S.D., Kuravi, S., Kimple, A.J., Willard, F.S., Siderovski, D.P.
Deposit date:2011-11-14
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
1IHJ
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CRYSTAL STRUCTURE OF THE N-TERMINAL PDZ DOMAIN OF INAD IN COMPLEX WITH A NORPA C-TERMINAL PEPTIDE
Descriptor:InaD, phospholipase C
Authors:Kimple, M.E., Siderovski, D.P., Sondek, J.
Deposit date:2001-04-19
Release date:2001-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
EMBO J., 20, 2001
1KJY
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CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT, REGULATOR OF G-PROTEIN SIGNALING 14, ...
Authors:Kimple, R.J., Kimple, M.E., Betts, L., Sondek, J., Siderovski, D.P.
Deposit date:2001-12-05
Release date:2002-05-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature, 416, 2002
1KZ7
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CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF MURINE DBS IN COMPLEX WITH THE PLACENTAL ISOFORM OF HUMAN CDC42
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1KZG
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DBSCDC42(Y889F)
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1LB1
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CRYSTAL STRUCTURE OF THE DBL AND PLECKSTRIN HOMOLOGY DOMAINS OF DBS IN COMPLEX WITH RHOA
Descriptor:Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T., Worthylake, D.K., Rossman, K.L., Betts, L., Pruitt, W.M., Siderovski, D.P., Der, C.J., Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1Y3A
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STRUCTURE OF G-ALPHA-I1 BOUND TO A GDP-SELECTIVE PEPTIDE PROVIDES INSIGHT INTO GUANINE NUCLEOTIDE EXCHANGE
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, KB752 peptide, ...
Authors:Johnston, C.A., Willard, F.S., Jezyk, M.R., Fredericks, Z., Bodor, E.T., Jones, M.B., Blaesius, R., Harden, T.K., Sondek, J., Watts, V.J., Ramer, J.K., Siderovski, D.P.
Deposit date:2004-11-24
Release date:2005-07-12
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
2G83
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STRUCTURE OF ACTIVATED G-ALPHA-I1 BOUND TO A NUCLEOTIDE-STATE-SELECTIVE PEPTIDE: MINIMAL DETERMINANTS FOR RECOGNIZING THE ACTIVE FORM OF A G PROTEIN ALPHA SUBUNIT
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, KB-1753 phage display peptide, ...
Authors:Johnston, C.A., Ramer, J.K., Blaesius, R., Kuhlman, B., Arshavsky, V.Y., Siderovski, D.P.
Deposit date:2006-03-01
Release date:2006-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer.
Biochemistry, 45, 2006
2PBI
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THE MULTIFUNCTIONAL NATURE OF GBETA5/RGS9 REVEALED FROM ITS CRYSTAL STRUCTURE
Descriptor:Regulator of G-protein signaling 9, Guanine nucleotide-binding protein subunit beta 5, GLYCEROL
Authors:Cheever, M.L., Snyder, J.T., Gershburg, S., Siderovski, D.P., Harden, T.K., Sondek, J.
Deposit date:2007-03-28
Release date:2008-01-29
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat.Struct.Mol.Biol., 15, 2008
3REF
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CRYSTAL STRUCTURE OF EHRHO1 BOUND TO GDP AND MAGNESIUM
Descriptor:Rho-like small GTPase, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bosch, D.E., Qiu, C., Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
3REG
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CRYSTAL STRUCTURE OF EHRHO1 BOUND TO A GTP ANALOG AND MAGNESIUM
Descriptor:Rho-like small GTPase, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Bosch, D.E., Qiu, C., Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
3UMR
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CRYSTAL STRUCTURE OF THE G202D MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Johnston, C.A., Afshar, K., Snyder, J.T., Tall, G.G., Gonczy, P., Siderovski, D.P., Willard, F.S.
Deposit date:2011-11-14
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans
To be Published
4DVG
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CRYSTAL STRUCTURE OF E. HISTOLYTICA FORMIN1 BOUND TO EHRHO1-GTPGAMMAS
Descriptor:Rho-like small GTPase, Diaphanous protein, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-02-23
Release date:2012-11-14
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Entamoeba histolytica Rho1 Regulates Actin Polymerization through a Divergent, Diaphanous-Related Formin.
Biochemistry, 51, 2012
4FID
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CRYSTAL STRUCTURE OF A HETEROTRIMERIC G-PROTEIN SUBUNIT FROM ENTAMOEBA HISTOLYTICA, EHG-ALPHA-1
Descriptor:G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE
Authors:Bosch, D.E., Kimple, A.J., Muller, R.E., Gigure, P.M., Willard, F.S., Machius, M., Temple, B.R., Siderovski, D.P.
Deposit date:2012-06-08
Release date:2012-11-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.
Plos Pathog., 8, 2012
4GOU
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CRYSTAL STRUCTURE OF AN RGS-RHOGEF FROM ENTAMOEBA HISTOLYTICA
Descriptor:EhRGS-RhoGEF
Authors:Bosch, D.E., Kimple, A.J., Muller, R.E., Willard, F.S., Machius, M., Siderovski, D.P.
Deposit date:2012-08-20
Release date:2013-01-09
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.
Structure, 21, 2013
4GPR
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CRYSTAL STRUCTURE OF EHUBC5, A UBIQUITIN CONJUGATING ENZYME FROM ENTAMOEBA HISTOLYTICA
Descriptor:Ubiquitin-conjugating enzyme family protein, COBALT (II) ION
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-08-21
Release date:2012-12-12
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GSW
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CRYSTAL STRUCTURE OF UBIQUITIN FROM ENTAMOEBA HISTOLYTICA TO 2.15 ANGSTROM
Descriptor:Ubiquitin, SULFATE ION
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-08-28
Release date:2012-12-12
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GU2
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CRYSTAL STRUCTURE OF UBIQUITIN FROM ENTAMOEBA HISTOLYTICA TO 1.35 ANGSTROM
Descriptor:Ubiquitin
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-08-29
Release date:2012-12-12
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4MIT
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CRYSTAL STRUCTURE OF E. HISTOLYTICA RACC BOUND TO THE EHPAK4 PBD
Descriptor:Rho family GTPase, Serine/threonine protein kinase PAK, putative, ...
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2013-09-02
Release date:2014-09-03
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors.
Biochemistry, 54, 2015
1KI1
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GUANINE NUCLEOTIDE EXCHANGE REGION OF INTERSECTIN IN COMPLEX WITH CDC42
Descriptor:G25K GTP-binding protein, placental isoform, intersectin long form, ...
Authors:Snyder, J.T., Pruitt, W.M., Der, C.J., Sondek, J.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
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