Author results

5UJ0
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STRUCTURE OF T4PNKP 3' PHOSPHATASE COVALENTLY BOUND TO BEF3
分子名称:Polynucleotide kinase, MAGNESIUM ION, GLYCEROL
著者Shuman, S., Chatterjee, D.
登録日2017-01-16
公開日2017-02-08
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Truncated T4Pnk covalently bound to BeF3
To Be Published
2OWO
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LAST STOP ON THE ROAD TO REPAIR: STRUCTURE OF E.COLI DNA LIGASE BOUND TO NICKED DNA-ADENYLATE
分子名称:26-MER, 5'-D(*AP*CP*AP*AP*TP*TP*GP*CP*GP*AP*CP*(OMC)P*C)-3', 5'-D(*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*G)-3', ...
著者Shuman, S., Nandakumar, J., Nair, P.A.
登録日2007-02-16
公開日2007-05-15
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Last Stop on the Road to Repair: Structure of E. coli DNA Ligase Bound to Nicked DNA-Adenylate.
Mol.Cell, 26, 2007
2QY2
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CHARACTERIZATION OF A TRIFUNCTIONAL MIMIVIRUS MRNA CAPPING ENZYME AND CRYSTAL STRUCTURE OF THE RNA TRIPHOSPHATASE DOMAINM.
分子名称:Probable mRNA-capping enzyme, ACETATE ION, CITRATE ANION
著者Shuman, S., Benarroch, D., Smith, P.
登録日2007-08-13
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain.
Structure, 16, 2008
3KGD
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CRYSTAL STRUCTURE OF E. COLI RNA 3' CYCLASE
分子名称:RNA 3'-terminal phosphate cyclase, ADENOSINE MONOPHOSPHATE, GLYCEROL, ...
著者Shuman, S., Tanaka, N., Smith, P.
登録日2009-10-28
公開日2010-04-21
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer.
Structure, 18, 2010
3N9B
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CRYSTAL STRUCTURE OF THE P. AERUGINOSA LIGD PHOSPHOESTERASE DOMAIN
分子名称:Probable ATP-dependent DNA ligase, SULFATE ION, CHLORIDE ION, ...
著者Shuman, S., Nair, P., Smith, P.
登録日2010-05-28
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily
Proc.Natl.Acad.Sci.USA, 107, 2010
3N9D
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MONOCLINIC STRUCTURE OF P. AERUGINOSA LIGD PHOSPHOESTERASE DOMAIN
分子名称:Probable ATP-dependent DNA ligase, MANGANESE (II) ION, SULFATE ION, ...
著者Shuman, S., Nair, P., Smith, P.
登録日2010-05-28
公開日2010-08-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily
Proc.Natl.Acad.Sci.USA, 107, 2010
4MDE
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STRUCTURE OF BACTERIAL POLYNUCLEOTIDE KINASE PRODUCT COMPLEX BOUND TO GDP AND DNA
分子名称:Metallophosphoesterase, DNA (5'-D(P*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-DIPHOSPHATE, ...
著者Shuman, S., Das, U., Wang, L.K., Smith, P., Jacewicz, A.
登録日2013-08-22
公開日2013-11-06
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition.
Nucleic Acids Res., 42, 2014
4MDF
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STRUCTURE OF BACTERIAL POLYNUCLEOTIDE KINASE MICHAELIS COMPLEX BOUND TO GTP AND DNA
分子名称:Metallophosphoesterase, DNA (5'-D(*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, ...
著者Shuman, S., Das, U., Wang, L.K., Smith, P., Jacewicz, A.
登録日2013-08-22
公開日2013-11-06
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (1.727 Å)
主引用文献Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition.
Nucleic Acids Res., 42, 2014
5U32
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CRYSTAL STRUCTURE OF FUNGAL RNA KINASE
分子名称:tRNA ligase, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Shuman, S., Goldgur, Y., Remus, B.S.
登録日2016-12-01
公開日2017-11-15
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (2.191 Å)
主引用文献Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase.
Nucleic Acids Res., 45, 2017
6C33
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MYCOBACTERIUM SMEGMATIS DNA FLAP ENDONUCLEASE
分子名称:5'-3' exonuclease, MANGANESE (II) ION
著者Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
登録日2018-01-09
公開日2018-03-28
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
6C34
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MYCOBACTERIUM SMEGMATIS DNA FLAP ENDONUCLEASE MUTANT D125N
分子名称:5'-3' exonuclease, MANGANESE (II) ION
著者Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
登録日2018-01-09
公開日2018-03-28
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
6C35
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MYCOBACTERIUM SMEGMATIS FLAP ENDONUCLEASE MUTANT D148N
分子名称:5'-3' exonuclease, MANGANESE (II) ION
著者Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
登録日2018-01-09
公開日2018-03-28
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.803 Å)
主引用文献Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
6C36
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MYCOBACTERIUM SMEGMATIS FLAP ENDONUCLEASE MUTANT D208N
分子名称:5'-3' exonuclease, MANGANESE (II) ION, PHOSPHATE ION
著者Shuman, S., Goldgur, Y., Carl, A., Uson, M.L.
登録日2018-01-09
公開日2018-03-28
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
6E3A
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TRNA 2'-PHOSPHOTRANSFERASE
分子名称:Probable RNA 2'-phosphotransferase, COENZYME A, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate
著者Shuman, S., Goldgur, Y., Banerjee, A.
登録日2018-07-13
公開日2019-03-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4recognition and ADP-ribosylation.
Nat Commun, 10, 2019
6EDE
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TRNA 2'-PHOSPHOTRANSFERASE
分子名称:Probable RNA 2'-phosphotransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate
著者Shuman, S., Goldgur, Y., Banerjee, A.
登録日2018-08-09
公開日2019-03-20
実験手法X-RAY DIFFRACTION (1.553 Å)
主引用文献Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4recognition and ADP-ribosylation.
Nat Commun, 10, 2019
6NHX
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MYCOBACTERIAL DNA LIGASE D COMPLEXED WITH ATP AND MES
分子名称:ATP-dependent DNA ligase, ADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Shuman, S., Unciuleac, M., Goldgur, Y.
登録日2018-12-24
公開日2019-02-13
最終更新日2019-04-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.
J. Biol. Chem., 294, 2019
6NHZ
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MYCOBACTERIAL DNA LIGASE D COMPLEXED WITH ATP AND MG
分子名称:ATP-dependent DNA ligase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Shuman, S., Unciuleac, M., Goldgur, Y.
登録日2018-12-24
公開日2019-02-13
最終更新日2019-04-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.
J. Biol. Chem., 294, 2019
1Z3C
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ENCEPHALITOZOOAN CUNICULI MRNA CAP (GUANINE-N7) METHYLTRANSFERASEIN COMPLEXED WITH AZOADOMET
分子名称:mRNA CAPPING ENZYME, S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE
著者Hausmann, S., Zhang, S., Fabrega, C., Schneller, S.W., Lima, C.D., Shuman, S.
登録日2005-03-11
公開日2005-03-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis.
J.Biol.Chem., 280, 2005
1RI1
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STRUCTURE AND MECHANISM OF MRNA CAP (GUANINE N-7) METHYLTRANSFERASE
分子名称:mRNA CAPPING ENZYME, S-ADENOSYL-L-HOMOCYSTEINE, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE
著者Fabrega, C., Hausmann, S., Shen, V., Shuman, S., Lima, C.D.
登録日2003-11-16
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Mol.Cell, 13, 2004
1RI2
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STRUCTURE AND MECHANISM OF MRNA CAP (GUANINE N-7) METHYLTRANSFERASE
分子名称:mRNA CAPPING ENZYME, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE
著者Fabrega, C., Hausmann, S., Shen, V., Shuman, S., Lima, C.D.
登録日2003-11-16
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Mol.Cell, 13, 2004
1RI3
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STRUCTURE AND MECHANISM OF MRNA CAP (GUANINE N-7) METHYLTRANSFERASE
分子名称:mRNA CAPPING ENZYME, S-ADENOSYL-L-HOMOCYSTEINE
著者Fabrega, C., Hausmann, S., Shen, V., Shuman, S., Lima, C.D.
登録日2003-11-16
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Mol.Cell, 13, 2004
1RI4
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STRUCTURE AND MECHANISM OF MRNA CAP (GUANINE N-7) METHYLTRANSFERASE
分子名称:mRNA CAPPING ENZYME, S-ADENOSYLMETHIONINE
著者Fabrega, C., Hausmann, S., Shen, V., Shuman, S., Lima, C.D.
登録日2003-11-16
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Mol.Cell, 13, 2004
1RI5
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STRUCTURE AND MECHANISM OF MRNA CAP (GUANINE N-7) METHYLTRANSFERASE
分子名称:mRNA CAPPING ENZYME
著者Fabrega, C., Hausmann, S., Shen, V., Shuman, S., Lima, C.D., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2003-11-16
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Mol.Cell, 13, 2004
4CKB
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VACCINIA VIRUS CAPPING ENZYME COMPLEXED WITH GTP AND SAH
分子名称:MRNA-CAPPING ENZYME CATALYTIC SUBUNIT, MRNA-CAPPING ENZYME REGULATORY SUBUNIT, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Kyrieleis, O.J.P., Chang, J., de la Pena, M., Shuman, S., Cusack, S.
登録日2014-01-02
公開日2014-03-19
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Vaccinia Virus Mrna Capping Enzyme Provides Insights Into the Mechanism and Evolution of the Capping Apparatus.
Structure, 22, 2014
4CKC
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VACCINIA VIRUS CAPPING ENZYME COMPLEXED WITH SAH (MONOCLINIC FORM)
分子名称:MRNA-CAPPING ENZYME CATALYTIC SUBUNIT, MRNA-CAPPING ENZYME REGULATORY SUBUNIT, S-ADENOSYL-L-HOMOCYSTEINE
著者Kyrieleis, O.J.P., Chang, J., de la Pena, M., Shuman, S., Cusack, S.
登録日2014-01-02
公開日2014-03-19
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structure of Vaccinia Virus Mrna Capping Enzyme Provides Insights Into the Mechanism and Evolution of the Capping Apparatus.
Structure, 22, 2014