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2OY0
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CRYSTAL STRUCTURE OF THE WEST NILE VIRUS METHYLTRANSFERASE
分子名称:Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Li, H.M., Zhao, Y.W., Guo, Y., Shi, P.Y.
登録日2007-02-21
公開日2007-04-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and Function of Flavivirus NS5 Methyltransferase.
J.Virol., 81, 2007
2XBM
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CRYSTAL STRUCTURE OF THE DENGUE VIRUS METHYLTRANSFERASE BOUND TO A 5'- CAPPED OCTAMERIC RNA
分子名称:NONSTRUCTURAL PROTEIN NS5, 5'-(*G3AP*GP*AP*AP*CP*CP*UP*GP*A)-3', SULFATE ION, ...
著者Yap, L.J., Luo, D.H., Chung, K.Y., Lim, S.P., Bodenreider, C., Noble, C., Shi, P.Y., Lescar, J.
登録日2010-04-13
公開日2010-09-29
最終更新日2012-04-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5'-Capped Octameric RNA
Plos One, 5, 2010
3J05
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THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH HMAB 14C10 FAB
分子名称:envelope protein
著者Teoh, E.P., Kukkaro, P., Teo, E.W., Lim, A., Tan, T.T., Shi, P.Y., Yip, A., Schul, W., Leo, Y.S., Chan, S.H., Smith, K.G.C., Ooi, E.E., Kemeny, D.M., Ng, G., Ng, M.L., Alonso, S., Fisher, D., Hanson, B., Lok, S.M., MacAry, P.A.
登録日2011-04-01
公開日2012-07-04
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (7 Å)
主引用文献The structural basis for serotype-specific neutralization of dengue virus by a human antibody.
Sci Transl Med, 4, 2012
4CAU
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THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB
分子名称:ENVELOPE PROTEIN E, FAB 14C10
著者Teoh, E.P., Kukkaro, P., Teo, E.W., Lim, A.P., Tan, T.T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V.A., Leo, Y.S., Chan, S.H., Smith, K.G., Chan, A.H., Zou, G., Ooi, E.E., Kemeny, D.M., Tan, G.K., Ng, J.K., Ng, M.L., Alonso, S., Fisher, D., Shi, P.Y., Hanson, B.J., Lok, S.M., Macary, P.A.
登録日2013-10-09
公開日2013-10-16
最終更新日2017-08-23
実験手法ELECTRON MICROSCOPY (7 Å)
主引用文献The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody.
Sci.Trans.Med, 4, 2012
5TPY
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CRYSTAL STRUCTURE OF AN EXONUCLEASE RESISTANT RNA FROM ZIKA VIRUS
分子名称:RNA (71-MER), MAGNESIUM ION, HEXANE-1,6-DIOL
著者Akiyama, B.M., Laurence, H.M., Massey, A.R., Costantino, D.A., Xie, X., Yang, Y., Shi, P.-Y., Nix, J.C., Beckham, J.D., Kieft, J.S.
登録日2016-10-21
公開日2016-12-14
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (2.805 Å)
主引用文献Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
Science, 354, 2016
2M0S
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SOLUTION STRUCTURE OF THE TRANS-MEMBRANE DOMAIN OF THE NS2A OF DENGUE VIRUS
分子名称:NS2A protein
著者Gayen, S., Kang, C.
登録日2012-11-05
公開日2013-02-27
最終更新日2013-04-24
実験手法SOLUTION NMR
主引用文献Membrane Topology and Function of Dengue Virus NS2A Protein.
J.Virol., 87, 2013
3LKZ
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STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE
分子名称:Non-structural protein 5, SINEFUNGIN, GLYCEROL
著者Liu, L.H., Li, H.M.
登録日2010-01-28
公開日2010-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
J.Biol.Chem., 285, 2010
3P8Z
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DENGUE METHYLTRANSFERASE BOUND TO A SAM-BASED INHIBITOR
分子名称:Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE
著者Noble, C.G., Yap, L.J., Lescar, J.
登録日2010-10-15
公開日2010-12-08
最終更新日2011-09-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3P97
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO THE SUBSTRATE S-ADENOSYL METHIONINE
分子名称:Non-structural protein 5, S-ADENOSYLMETHIONINE
著者Noble, C.G., Yap, L.J., Lescar, J.
登録日2010-10-16
公開日2010-12-08
最終更新日2011-09-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3U1I
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DENGUE VIRUS PROTEASE COVALENTLY BOUND TO A PEPTIDE
分子名称:Serine protease subunit NS2B, Serine protease NS3, peptide of (BEZ)(NLE)KR(OAR), ...
著者Noble, C.G.
登録日2011-09-29
公開日2011-11-09
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Ligand-bound structures of the dengue virus protease reveal the active conformation
J.Virol., 86, 2012
3U1J
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APROTININ BOUND TO DENGUE VIRUS PROTEASE
分子名称:Serine protease subunit NS2B, Serine protease NS3, Pancreatic trypsin inhibitor
著者Noble, C.G.
登録日2011-09-30
公開日2011-11-09
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Ligand-bound structures of the dengue virus protease reveal the active conformation
J.Virol., 86, 2012
4IKA
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CRYSTAL STRUCTURE OF EV71 3DPOL-VPG
分子名称:3Dpol, VPg, NICKEL (II) ION
著者Chen, C., Wang, Y.X., Lou, Z.Y.
登録日2012-12-25
公開日2013-09-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation
J.Virol., 87, 2013
4R8R
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DENGUE VIRUS SEROTYPE 3 METHYLTRANSFERASE WITHOUT A BOUND S-ADENOSYL METHIONINE
分子名称:nonstructural protein NS5
著者Noble, C.G.
登録日2014-09-02
公開日2014-10-15
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
4R8S
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DENGUE SEROTYPE 3 METHYLTRANSFERASE BOUND TO SINEFUNGIN
分子名称:nonstructural protein NS5, SINEFUNGIN
著者Noble, C.G.
登録日2014-09-02
公開日2014-10-15
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
5F3T
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO JF-31-MG46
分子名称:RNA-DEPENDENT RNA POLYMERASE, ZINC ION, 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid
著者Noble, C.G.
登録日2015-12-03
公開日2016-02-24
最終更新日2016-05-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J.Biol.Chem., 291, 2016
5F3Z
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO PC-79-SH52
分子名称:Genome polyprotein, ZINC ION, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid
著者Noble, C.G.
登録日2015-12-03
公開日2016-02-24
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5F41
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO FD-83-KI26
分子名称:Genome polyprotein, ZINC ION, 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid
著者Noble, C.G.
登録日2015-12-03
公開日2016-02-24
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5HMW
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 5
分子名称:RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-biphenyl-3,5-diyldiacetic acid
著者Noble, C.G.
登録日2016-01-17
公開日2016-03-30
最終更新日2016-05-18
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HMX
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 10
分子名称:RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid
著者Noble, C.G.
登録日2016-01-17
公開日2016-03-30
最終更新日2016-05-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HMY
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 15
分子名称:RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid
著者Noble, C.G.
登録日2016-01-17
公開日2016-03-30
最終更新日2016-05-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
5HMZ
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 23
分子名称:RNA-directed RNA polymerase NS5, ZINC ION, 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide
著者Noble, C.G.
登録日2016-01-17
公開日2016-03-30
最終更新日2016-05-18
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HN0
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 4
分子名称:RNA-directed RNA polymerase NS5, ZINC ION, (6-hydroxybiphenyl-3-yl)acetic acid
著者Noble, C.G.
登録日2016-01-17
公開日2016-03-30
最終更新日2016-05-18
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
5I3P
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
分子名称:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide
著者Noble, C.G.
登録日2016-02-10
公開日2016-07-06
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5I3Q
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29
分子名称:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide
著者Noble, C.G.
登録日2016-02-10
公開日2016-07-06
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJR
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 29
分子名称:Genome polyprotein, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Lescar, J., El Sahili, A.
登録日2016-04-25
公開日2016-07-06
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
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