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2OY0
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CRYSTAL STRUCTURE OF THE WEST NILE VIRUS METHYLTRANSFERASE
Descriptor:Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, H.M., Zhao, Y.W., Guo, Y., Shi, P.Y.
Deposit date:2007-02-21
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Function of Flavivirus NS5 Methyltransferase.
J.Virol., 81, 2007
2XBM
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CRYSTAL STRUCTURE OF THE DENGUE VIRUS METHYLTRANSFERASE BOUND TO A 5'- CAPPED OCTAMERIC RNA
Descriptor:NONSTRUCTURAL PROTEIN NS5, 5'-(*G3AP*GP*AP*AP*CP*CP*UP*GP*A)-3', SULFATE ION, ...
Authors:Yap, L.J., Luo, D.H., Chung, K.Y., Lim, S.P., Bodenreider, C., Noble, C., Shi, P.Y., Lescar, J.
Deposit date:2010-04-13
Release date:2010-09-29
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5'-Capped Octameric RNA
Plos One, 5, 2010
3J05
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THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH HMAB 14C10 FAB
Descriptor:envelope protein
Authors:Teoh, E.P., Kukkaro, P., Teo, E.W., Lim, A., Tan, T.T., Shi, P.Y., Yip, A., Schul, W., Leo, Y.S., Chan, S.H., Smith, K.G.C., Ooi, E.E., Kemeny, D.M., Ng, G., Ng, M.L., Alonso, S., Fisher, D., Hanson, B., Lok, S.M., MacAry, P.A.
Deposit date:2011-04-01
Release date:2012-07-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7 Å)
Cite:The structural basis for serotype-specific neutralization of dengue virus by a human antibody.
Sci Transl Med, 4, 2012
4CAU
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THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB
Descriptor:ENVELOPE PROTEIN E, FAB 14C10
Authors:Teoh, E.P., Kukkaro, P., Teo, E.W., Lim, A.P., Tan, T.T., Yip, A., Schul, W., Aung, M., Kostyuchenko, V.A., Leo, Y.S., Chan, S.H., Smith, K.G., Chan, A.H., Zou, G., Ooi, E.E., Kemeny, D.M., Tan, G.K., Ng, J.K., Ng, M.L., Alonso, S., Fisher, D., Shi, P.Y., Hanson, B.J., Lok, S.M., Macary, P.A.
Deposit date:2013-10-09
Release date:2013-10-16
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (7 Å)
Cite:The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody.
Sci.Trans.Med, 4, 2012
5TPY
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CRYSTAL STRUCTURE OF AN EXONUCLEASE RESISTANT RNA FROM ZIKA VIRUS
Descriptor:RNA (71-MER), MAGNESIUM ION, HEXANE-1,6-DIOL
Authors:Akiyama, B.M., Laurence, H.M., Massey, A.R., Costantino, D.A., Xie, X., Yang, Y., Shi, P.-Y., Nix, J.C., Beckham, J.D., Kieft, J.S.
Deposit date:2016-10-21
Release date:2016-12-14
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
Science, 354, 2016
2M0S
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SOLUTION STRUCTURE OF THE TRANS-MEMBRANE DOMAIN OF THE NS2A OF DENGUE VIRUS
Descriptor:NS2A protein
Authors:Gayen, S., Kang, C.
Deposit date:2012-11-05
Release date:2013-02-27
Last modified:2013-04-24
Method:SOLUTION NMR
Cite:Membrane Topology and Function of Dengue Virus NS2A Protein.
J.Virol., 87, 2013
3LKZ
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STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE
Descriptor:Non-structural protein 5, SINEFUNGIN, GLYCEROL
Authors:Liu, L.H., Li, H.M.
Deposit date:2010-01-28
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
J.Biol.Chem., 285, 2010
3P8Z
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DENGUE METHYLTRANSFERASE BOUND TO A SAM-BASED INHIBITOR
Descriptor:Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-15
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3P97
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO THE SUBSTRATE S-ADENOSYL METHIONINE
Descriptor:Non-structural protein 5, S-ADENOSYLMETHIONINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-16
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3U1I
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DENGUE VIRUS PROTEASE COVALENTLY BOUND TO A PEPTIDE
Descriptor:Serine protease subunit NS2B, Serine protease NS3, peptide of (BEZ)(NLE)KR(OAR), ...
Authors:Noble, C.G.
Deposit date:2011-09-29
Release date:2011-11-09
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ligand-bound structures of the dengue virus protease reveal the active conformation
J.Virol., 86, 2012
3U1J
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APROTININ BOUND TO DENGUE VIRUS PROTEASE
Descriptor:Serine protease subunit NS2B, Serine protease NS3, Pancreatic trypsin inhibitor
Authors:Noble, C.G.
Deposit date:2011-09-30
Release date:2011-11-09
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand-bound structures of the dengue virus protease reveal the active conformation
J.Virol., 86, 2012
4IKA
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CRYSTAL STRUCTURE OF EV71 3DPOL-VPG
Descriptor:3Dpol, VPg, NICKEL (II) ION
Authors:Chen, C., Wang, Y.X., Lou, Z.Y.
Deposit date:2012-12-25
Release date:2013-09-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation
J.Virol., 87, 2013
4R8R
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DENGUE VIRUS SEROTYPE 3 METHYLTRANSFERASE WITHOUT A BOUND S-ADENOSYL METHIONINE
Descriptor:nonstructural protein NS5
Authors:Noble, C.G.
Deposit date:2014-09-02
Release date:2014-10-15
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
4R8S
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DENGUE SEROTYPE 3 METHYLTRANSFERASE BOUND TO SINEFUNGIN
Descriptor:nonstructural protein NS5, SINEFUNGIN
Authors:Noble, C.G.
Deposit date:2014-09-02
Release date:2014-10-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
5F3T
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO JF-31-MG46
Descriptor:RNA-DEPENDENT RNA POLYMERASE, ZINC ION, 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J.Biol.Chem., 291, 2016
5F3Z
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO PC-79-SH52
Descriptor:Genome polyprotein, ZINC ION, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5F41
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO FD-83-KI26
Descriptor:Genome polyprotein, ZINC ION, 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5HMW
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 5
Descriptor:RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-biphenyl-3,5-diyldiacetic acid
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HMX
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 10
Descriptor:RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HMY
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 15
Descriptor:RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
5HMZ
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 23
Descriptor:RNA-directed RNA polymerase NS5, ZINC ION, 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
5HN0
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 4
Descriptor:RNA-directed RNA polymerase NS5, ZINC ION, (6-hydroxybiphenyl-3-yl)acetic acid
Authors:Noble, C.G.
Deposit date:2016-01-17
Release date:2016-03-30
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
5I3P
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5I3Q
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJR
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
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