Author results

3EAP
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CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF ARHGAP11A
Descriptor:Rho GTPase-activating protein 11A, UNKNOWN ATOM OR ION
Authors:Shen, Y., Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2008-08-26
Release date:2008-09-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the RhoGAP domain of ARHGAP11A
To be Published
1LVC
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 2' DEOXY, 3' ANTHRANILOYL ATP
Descriptor:calmodulin-sensitive adenylate cyclase, calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Lee, Y.-S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M., Tang, W.-J.
Deposit date:2002-05-28
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Embo J., 21, 2002
1PK0
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CRYSTAL STRUCTURE OF THE EF3-CAM COMPLEXED WITH PMEAPP
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Tang, W.J.
Deposit date:2003-06-04
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc.Natl.Acad.Sci.USA, 101, 2004
1S26
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STRUCTURE OF ANTHRAX EDEMA FACTOR-CALMODULIN-ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE COMPLEX REVEALS AN ALTERNATIVE MODE OF ATP BINDING TO THE CATALYTIC SITE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Bohm, A., Tang, W.-J.
Deposit date:2004-01-08
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of anthrax edema factor-calmodulin-adenosine-5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site
Biochem.Biophys.Res.Commun., 317, 2004
3GF9
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEF DOMAIN
Descriptor:Intersectin 2, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tong, Y., Tempel, W., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-02-26
Release date:2009-03-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human Intersectin 2 RhoGEF domain
To be Published
3JZY
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 C2 DOMAIN
Descriptor:Intersectin 2, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tempel, W., Tong, Y., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-09-24
Release date:2009-10-06
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of human Intersectin 2 C2 domain
To be Published
3DZ8
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CRYSTAL STRUCTURE OF HUMAN RAB3B GTPASE BOUND WITH GDP
Descriptor:Ras-related protein Rab-3B, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tong, Y., Sukumar, D., Tempel, W., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wilkstrom, M., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-07-29
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human Rab3B GTPase bound with GDP
To be Published
3KH0
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CRYSTAL STRUCTURE OF THE RAS-ASSOCIATION (RA) DOMAIN OF RALGDS
Descriptor:Ral guanine nucleotide dissociation stimulator, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tempel, W., Wang, H., Tong, Y., Guan, X., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-10-29
Release date:2009-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the Ras-association (RA) domain of RALGDS
to be published
3LXX
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CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILY MEMBER 4
Descriptor:GTPase IMAP family member 4, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Shen, Y., Nedyalkova, L., Tong, Y., Tempel, W., Mackenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Andrews, D.W., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-02-25
Release date:2010-03-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of human GTPase IMAP family member 4
to be published
3MPX
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CRYSTAL STRUCTURE OF THE DH AND PH-1 DOMAINS OF HUMAN FGD5
Descriptor:FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION
Authors:Shen, Y., Nedyalkova, L., Tong, Y., Tempel, W., Crombet, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-04-27
Release date:2010-06-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the DH and PH-1 domains of human FGD5
TO BE PUBLISHED
3NEY
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF MPP1/P55
Descriptor:55 kDa erythrocyte membrane protein, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tong, Y., Zhong, N., Guan, X., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-06-09
Release date:2010-08-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of the kinase domain of MPP1/p55
To be Published
6BBK
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N-TERMINALLY TRUNCATED GROUP I PILA FROM PSEUDOMONAS AERUGINOSA STRAIN 1244
Descriptor:Fimbrial protein
Authors:Shen, Y., Guarne, A., Nguyen, Y., Burrows, L.L.
Deposit date:2017-10-18
Release date:2018-11-21
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:N-terminally truncated group I PilA from Pseudomonas aeruginosa strain 1244
To Be Published
1NR3
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SOLUTION STRUCTURE OF THE PROTEIN MTH0916: THE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TT212
Descriptor:DNA-binding protein tfx
Authors:Shen, Y., Liu, G., Bhaskaran, R., Yee, A., Arrowsmith, C., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-01-23
Release date:2003-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:SOLUTION STRUCTURE OF THE PROTEIN MTH0916: THE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TT212
To be Published
1T17
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SOLUTION STRUCTURE OF THE 18 KDA PROTEIN CC1736 FROM CAULOBACTER CRESCENTUS: THE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET CCR19
Descriptor:conserved hypothetical protein
Authors:Shen, Y., Atreya, H.S., Acton, T., Xiao, R., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-04-15
Release date:2005-01-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of the 18 kDa protein CC1736 from Caulobacter crescentus identifies a member of the START domain superfamily and suggests residues mediating substrate specificity.
Proteins, 58, 2005
1W93
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CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE DOMAIN OF ACETYL-COENZYME A CARBOXYLASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:ACETYL-COENZYME A CARBOXYLASE
Authors:Shen, Y., Volrath, S.L., Weatherly, S.C., Elich, T.D., Tong, L.
Deposit date:2004-10-05
Release date:2005-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
1W96
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CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE DOMAIN OF ACETYL-COENZYME A CARBOXYLASE FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH SORAPHEN A
Descriptor:ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A
Authors:Shen, Y., Volrath, S.L., Weatherly, S.C., Elich, T.D., Tong, L.
Deposit date:2004-10-06
Release date:2005-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
1XFU
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) TRUNCATION MUTANT, EF-DELTA 64 IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFW
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 3'5' CYCLIC AMP (CAMP)
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFX
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN IN THE PRESENCE OF 10 MILLIMOLAR EXOGENOUSLY ADDED CALCIUM CHLORIDE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFY
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFZ
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN IN THE PRESENCE OF 1 MILLIMOLAR EXOGENOUSLY ADDED CALCIUM CHLORIDE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XN7
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SOLUTION STRUCTURE OF E.COLI PROTEIN YHGG: THE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ET95
Descriptor:Hypothetical protein yhgG
Authors:Shen, Y., Acton, T., Atreya, H.S., Ma, L., Liu, G., Xiao, R., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-10-04
Release date:2004-12-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of E.Coli Protein yhgG: The Northeast Structural Genomics Consortium Target ET95
To be Published
1Y0V
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND PYROPHOSPHATE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.-J.
Deposit date:2004-11-16
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
Embo J., 24, 2005
2G47
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH AMYLOID-BETA (1-40)
Descriptor:Insulin-degrading enzyme, amyloid protein beta A4, 1,4-DIETHYLENE DIOXIDE
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-21
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G48
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH AMYLIN
Descriptor:Insulin-degrading enzyme, Islet amyloid polypeptide, 1,4-DIETHYLENE DIOXIDE
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-21
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006