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6ULG
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BU of 6ulg by Molmil
Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex
Descriptor: Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M.
Deposit date:2019-10-08
Release date:2019-11-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Cell, 179, 2019
6CET
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BU of 6cet by Molmil
Cryo-EM structure of GATOR1
Descriptor: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3
Authors:Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M.
Deposit date:2018-02-12
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Nature, 556, 2018
6CES
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BU of 6ces by Molmil
Cryo-EM structure of GATOR1-RAG
Descriptor: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ...
Authors:Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M.
Deposit date:2018-02-12
Release date:2018-03-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Nature, 556, 2018
6XS6
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BU of 6xs6 by Molmil
SARS-CoV-2 Spike D614G variant, minus RBD
Descriptor: Spike glycoprotein
Authors:Wang, X, Egri, S.B, Dudkina, N, Luban, J, Shen, K.
Deposit date:2020-07-15
Release date:2020-07-22
Last modified:2020-11-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Cell, 183, 2020
8FW5
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BU of 8fw5 by Molmil
Chimeric HsGATOR1-SpGtr-SpLam complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Tettoni, S.D, Egri, S.B, Doxsey, D.D, Ouch, C, Chang, J, Song, K, Xu, C, Shen, K.
Deposit date:2023-01-20
Release date:2023-07-26
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing.
Structure, 31, 2023
7T3B
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BU of 7t3b by Molmil
GATOR1-RAG-RAGULATOR - GAP Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3C
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BU of 7t3c by Molmil
GATOR1-RAG-RAGULATOR - Dual Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3A
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BU of 7t3a by Molmil
GATOR1-RAG-RAGULATOR - Inhibitory Complex
Descriptor: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
5VOK
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BU of 5vok by Molmil
Crystal structure of the C7orf59-HBXIP dimer
Descriptor: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5
Authors:Rasheed, N, Nascimento, A.F.Z, Bar-Peled, L, Shen, K, Sabatini, D.M, Aparicio, R, Smetana, J.H.C.
Deposit date:2017-05-03
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly.
Febs Open Bio, 2019
8GB0
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BU of 8gb0 by Molmil
SARS-CoV-2 Spike H655Y variant, One RBD Open
Descriptor: Spike glycoprotein
Authors:Egri, S.B, Shen, K, Luban, J.
Deposit date:2023-02-24
Release date:2023-04-26
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness.
Biorxiv, 2023
2XXA
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BU of 2xxa by Molmil
The Crystal Structure of the Signal Recognition Particle (SRP) in Complex with its Receptor(SR)
Descriptor: 4.5S RNA, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Ataide, S.F, Schmitz, N, Shen, K, Ke, A, Shan, S, Doudna, J.A, Ban, N.
Deposit date:2010-11-09
Release date:2011-03-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:The Crystal Structure of the Signal Recognition Particle in Complex with its Receptor.
Science, 331, 2011
4C7O
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BU of 4c7o by Molmil
The structural basis of FtsY recruitment and GTPase activation by SRP RNA
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SIGNAL RECOGNITION PARTICLE PROTEIN, ...
Authors:Voigts-Hoffmann, F, Schmitz, N, Shen, K, Shan, S.O, Ataide, S.F, Ban, N.
Deposit date:2013-09-23
Release date:2013-11-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis of Ftsy Recruitment and Gtpase Activation by Srp RNA
Mol.Cell, 52, 2013
1PXH
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BU of 1pxh by Molmil
Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2
Descriptor: ACETIC ACID, MAGNESIUM ION, N-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC ACID, ...
Authors:Sun, J.P, Fedorov, A, Lee, S.Y, Guo, X.L, Shen, K, Lawrence, D.S, Almo, S.C, Zhang, Z.Y.
Deposit date:2003-07-04
Release date:2003-08-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.
J.Biol.Chem., 278, 2003
2CCH
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BU of 2cch by Molmil
The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ...
Authors:Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
2CCI
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BU of 2cci by Molmil
Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6 homolog, Cyclin-A2, ...
Authors:Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
J. Biol. Chem., 281, 2006
2GS6
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BU of 2gs6 by Molmil
Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate
Descriptor: CHLORIDE ION, Epidermal growth factor receptor, Peptide, ...
Authors:Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Cell(Cambridge,Mass.), 125, 2006
2GS7
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BU of 2gs7 by Molmil
Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP
Descriptor: Epidermal growth factor receptor, IODIDE ION, MAGNESIUM ION, ...
Authors:Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Cell(Cambridge,Mass.), 125, 2006
2GS2
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BU of 2gs2 by Molmil
Crystal Structure of the active EGFR kinase domain
Descriptor: Epidermal growth factor receptor
Authors:Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell(Cambridge,Mass.), 125, 2006
6CSM
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BU of 6csm by Molmil
Crystal structure of the natural light-gated anion channel GtACR1
Descriptor: GtACR1, OLEIC ACID, RETINAL
Authors:Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSN
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BU of 6csn by Molmil
Crystal structure of the designed light-gated anion channel iC++ at pH8.5
Descriptor: CHLORIDE ION, OLEIC ACID, RETINAL, ...
Authors:Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSO
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BU of 6cso by Molmil
Crystal structure of the designed light-gated anion channel iC++ at pH6.5
Descriptor: OLEIC ACID, RETINAL, iC++
Authors:Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
4FQ7
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BU of 4fq7 by Molmil
Crystal structure of the maleate isomerase Iso from Pseudomonas putida S16
Descriptor: Maleate cis-trans isomerase
Authors:Lu, Y, Chen, D, Zhang, Z, Li, Q, Wu, G, Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
4FQ5
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BU of 4fq5 by Molmil
Crystal structure of the maleate isomerase Iso(C200A) from Pseudomonas putida S16 with maleate
Descriptor: MALEIC ACID, Maleate cis-trans isomerase
Authors:Lu, Y, Chen, D, Zhang, Z, Li, Q, Wu, G, Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
6D39
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BU of 6d39 by Molmil
Photodissociable dimeric Dronpa green fluorescent protein variant V (pdDronpaV)
Descriptor: Fluorescent protein Dronpa, SULFATE ION
Authors:Zhou, X, Fan, L, Lin, M.
Deposit date:2018-04-15
Release date:2018-05-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Optical control of cell signaling by single-chain photoswitchable kinases.
Science, 355, 2017
6D38
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BU of 6d38 by Molmil
Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM)
Descriptor: Fluorescent protein Dronpa, SULFATE ION
Authors:Zhou, X, Fan, L, Lin, M.
Deposit date:2018-04-14
Release date:2018-05-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Optical control of cell signaling by single-chain photoswitchable kinases.
Science, 355, 2017

 

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