Author results

1YVF
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH INHIBITOR PHA-00729145
Descriptor:HCV NS5B POLYMERASE, PHOSPHATE ION, CHLORIDE ION, ...
Authors:Pfefferkorn, J.A., Greene, M.L., Nugent, R.A., Gross, R.J., Mitchell, M.A., Finzel, B.C., Harris, M.S., Wells, P.A., Shelly, J.A., Anstadt, R.A., Kilkuskie, R.E., Kopta, L.A., Schwende, F.J.
Deposit date:2005-02-15
Release date:2005-04-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid.
Bioorg.Med.Chem.Lett., 15, 2005
1HPO
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HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX
Descriptor:HIV-1 PROTEASE, 4-CYANO-N-(3-CYCLOPROPYL(5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-2-OXO-CYCLOOCTA[B]PYRAN-3-YL)METHYL)PHENYL BENZENSULFONAMIDE
Authors:Watenpaugh, K.D., Janakiraman, M.N.
Deposit date:1996-12-10
Release date:1997-04-21
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.
J.Med.Chem., 40, 1997
5UPJ
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HIV-2 PROTEASE/U99283 COMPLEX
Descriptor:HIV-2 PROTEASE, 5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOOCTA[B]PYRAN-2-ONE
Authors:Watenpaugh, K.D., Mulichak, A.M., Finzel, B.C.
Deposit date:1996-12-10
Release date:1997-04-21
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors.
J.Med.Chem., 38, 1995
6UPJ
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HIV-2 PROTEASE/U99294 COMPLEX
Descriptor:HIV-2 PROTEASE, 6,7,8,9-TETRAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOHEPTA[B]PYRAN-2-ONE
Authors:Watenpaugh, K.D., Mulichak, A.M., Finzel, B.C.
Deposit date:1996-12-10
Release date:1997-04-21
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors.
J.Med.Chem., 38, 1995
7UPJ
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HIV-1 PROTEASE/U101935 COMPLEX
Descriptor:HIV-1 PROTEASE, N-(3-CYCLOPROPYL(5,6,7,8,9,10-HEXAHYDRO-2-OXO-2H-CYCLOOCTA[B]PYRAN-3-YL)METHYL)PHENYLBENZENSULFONAMIDE
Authors:Watenpaugh, K.D., Janakiraman, M.N.
Deposit date:1996-12-05
Release date:1997-04-21
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.
J.Med.Chem., 40, 1997
1Z4U
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HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH INHIBITOR PHA-00799585
Descriptor:HCV NS5B POLYMERASE, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Pfefferkorn, J.A., Greene, M., Nugent, R., Gross, R.J., Mitchell, M.A., Finzel, B.C., Harris, M.S., Wells, P.A., Shelly, J.A., Anstadt, R.
Deposit date:2005-03-16
Release date:2005-06-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid
Bioorg.Med.Chem.Lett., 15, 2005