Author results

1FQV
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INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX
Descriptor:SKP2, SKP1
Authors:Schulman, B.A., Carrano, A.C., Jeffrey, P.D., Bowen, Z., Kinnucan, E.R., Finnin, M.S., Elledge, S.J., Harper, J.W., Pagano, M., Pavletich, N.P.
Deposit date:2000-09-06
Release date:2000-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
1FS1
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INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX
Descriptor:CYCLIN A/CDK2-ASSOCIATED P19, CYCLIN A/CDK2-ASSOCIATED P45
Authors:Schulman, B.A., Carrano, A.C., Jeffrey, P.D., Bowen, Z., Kinnucan, E.R.E., Finnin, M.S., Elledge, S.J., Harper, J.W., Pagano, M., Pavletich, N.P.
Deposit date:2000-09-08
Release date:2000-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
1FS2
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INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX
Descriptor:SKP2, SKP1
Authors:Schulman, B.A., Carrano, A.C., Jeffrey, P.D., Bowen, Z., Kinnucan, E.R.E., Finnin, M.S., Elledge, S.J., Harper, J.W., Pagano, M., Pavletich, N.P.
Deposit date:2000-09-08
Release date:2000-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
3IVB
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-MACROH2ASBCPEP1
Descriptor:Speckle-type POZ protein, Core histone macro-H2A.1, ZINC ION, ...
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-08-31
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure 9
To be Published
3IVQ
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-CISBC2
Descriptor:Speckle-type POZ protein, CiSBC2
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3IVV
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-PUCSBC1_PEP1
Descriptor:Speckle-type POZ protein, PucSBC1
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
1LDD
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STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCF UBIQUITIN LIGASE COMPLEX
Descriptor:Anaphase Promoting Complex
Authors:Zheng, N., Schulman, B.A., Song, L., Miller, J.J., Jeffrey, P.D., Wang, P., Chu, C., Koepp, D.M., Elledge, S.J., Pagano, M., Conaway, R.C., Conaway, J.W., Harper, J.W., Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1LDJ
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STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCF UBIQUITIN LIGASE COMPLEX
Descriptor:Cullin homolog 1, ring-box protein 1, ZINC ION
Authors:Zheng, N., Schulman, B.A., Song, L., Miller, J.J., Jeffrey, P.D., Wang, P., Chu, C., Koepp, D.M., Elledge, S.J., Pagano, M., Conaway, R.C., Conaway, J.W., Harper, J.W., Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1LDK
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STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCF UBIQUITIN LIGASE COMPLEX
Descriptor:CULLIN HOMOLOG, ring-box protein 1, CYCLIN A/CDK2-ASSOCIATED PROTEIN P19, ...
Authors:Zheng, N., Schulman, B.A., Song, L., Miller, J.J., Jeffrey, P.D., Wang, P., Chu, C., Koepp, D.M., Elledge, S.J., Pagano, M., Conaway, R.C., Conaway, J.W., Harper, J.W., Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1P22
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STRUCTURE OF A BETA-TRCP1-SKP1-BETA-CATENIN COMPLEX: DESTRUCTION MOTIF BINDING AND LYSINE SPECIFICITY ON THE SCFBETA-TRCP1 UBIQUITIN LIGASE
Descriptor:F-box/WD-repeat protein 1A, Skp1, Beta-catenin
Authors:Wu, G., Xu, G., Schulman, B.A., Jeffrey, P.D., Harper, J.W., Pavletich, N.P.
Deposit date:2003-04-14
Release date:2003-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of a beta-TrCP1-Skp1-beta-Catenin complex: destruction motif binding and lysine specificity of the SCFbeta-TrCP1 ubiquitin ligase
Mol.Cell, 11, 2003
1R4M
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APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX
Descriptor:amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ...
Authors:Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
1R4N
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APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX WITH ATP
Descriptor:amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ...
Authors:Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A.
Deposit date:2003-10-07
Release date:2003-12-23
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
1TT5
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STRUCTURE OF APPBP1-UBA3-UBC12N26: A UNIQUE E1-E2 INTERACTION REQUIRED FOR OPTIMAL CONJUGATION OF THE UBIQUITIN-LIKE PROTEIN NEDD8
Descriptor:amyloid protein-binding protein 1, ubiquitin-activating enzyme E1C isoform 1, Ubiquitin-conjugating enzyme E2 M, ...
Authors:Huang, D.T., Miller, D.W., Mathew, R., Cassell, R., Holton, J.M., Roussel, M.F., Schulman, B.A.
Deposit date:2004-06-21
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11, 2004
1Y8X
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STRUCTURAL BASIS FOR RECRUITMENT OF UBC12 BY AN E2-BINDING DOMAIN IN NEDD8'S E1
Descriptor:Ubiquitin-conjugating enzyme E2 M, Ubiquitin-activating enzyme E1C
Authors:Huang, D.T., Paydar, A., Zhuang, M., Waddell, M.B., Holton, J.M., Schulman, B.A.
Deposit date:2004-12-13
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
1YOV
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INSIGHTS INTO THE UBIQUITIN TRANSFER CASCADE FROM THE REFINED STRUCTURE OF THE ACTIVATING ENZYME FOR NEDD8
Descriptor:Amyloid protein-binding protein 1, Ubiquitin-activating enzyme E1C, ZINC ION
Authors:Walden, H., Podgorski, M.S., Schulman, B.A.
Deposit date:2005-01-28
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8
Nature, 422, 2003
1ZFN
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STRUCTURAL ANALYSIS OF ESCHERICHIA COLI THIF
Descriptor:Adenylyltransferase thiF, ZINC ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Duda, D.M., Walden, H., Sfondouris, J., Schulman, B.A.
Deposit date:2005-04-20
Release date:2005-06-14
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Analysis of Escherichia Coli ThiF.
J.Mol.Biol., 349, 2005
1ZKM
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STRUCTURAL ANALYSIS OF ESCHERICHIA COLI THIF
Descriptor:Adenylyltransferase thiF, ZINC ION
Authors:Duda, D.M., Walden, H., Sfondouris, J., Schulman, B.A.
Deposit date:2005-05-03
Release date:2005-06-14
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Analysis of Escherichia Coli ThiF.
J.Mol.Biol., 349, 2005
2ASS
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CRYSTAL STRUCTURE OF THE SKP1-SKP2-CKS1 COMPLEX
Descriptor:S-phase kinase-associated protein 1A, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ...
Authors:Hao, B., Zhang, N., Schulman, B.A., Wu, G., Pagano, M., Pavletich, N.P.
Deposit date:2005-08-24
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20, 2005
2AST
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CRYSTAL STRUCTURE OF SKP1-SKP2-CKS1 IN COMPLEX WITH A P27 PEPTIDE
Descriptor:S-phase kinase-associated protein 1A, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ...
Authors:Hao, B., Zhang, N., Schulman, B.A., Wu, G., Pagano, M., Pavletich, N.P.
Deposit date:2005-08-24
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20, 2005
2EKE
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STRUCTURE OF A SUMO-BINDING-MOTIF MIMIC BOUND TO SMT3P-UBC9P: CONSERVATION OF A NONCOVALENT UBIQUITIN-LIKE PROTEIN-E2 COMPLEX AS A PLATFORM FOR SELECTIVE INTERACTIONS WITHIN A SUMO PATHWAY
Descriptor:SUMO-conjugating enzyme UBC9, Ubiquitin-like protein SMT3
Authors:Duda, D.M., Schulman, B.A.
Deposit date:2007-03-23
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a SUMO-binding-motif Mimic Bound to Smt3p-Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein-E2 Complex as a Platform for Selective Interactions within a SUMO Pathway
J.Mol.Biol., 369, 2007
2GJD
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DISTINCT FUNCTIONAL DOMAINS OF UBC9 DICTATE CELL SURVIVAL AND RESISTANCE TO GENOTOXIC STRESS
Descriptor:Ubiquitin-conjugating enzyme E2-18 kDa
Authors:van Waardenburg, R.C., Duda, D.M., Lancaster, C.S., Schulman, B.A., Bjornsti, M.A.
Deposit date:2006-03-30
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Distinct functional domains of ubc9 dictate cell survival and resistance to genotoxic stress.
Mol.Cell.Biol., 26, 2006
2M6N
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3D SOLUTION STRUCTURE OF EMI1 (EARLY MITOTIC INHIBITOR 1)
Descriptor:F-box only protein 5, ZINC ION
Authors:Frye, J.J., Brown, N.G., Petzold, G., Watson, E.R., Royappa, G.R., Nourse, A., Jarvis, M., Kriwacki, R.W., Peters, J., Stark, H., Schulman, B.A.
Deposit date:2013-04-06
Release date:2013-05-29
Last modified:2013-07-17
Method:SOLUTION NMR
Cite:Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.
Nat.Struct.Mol.Biol., 20, 2013
2NVU
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STRUCTURE OF APPBP1-UBA3~NEDD8-NEDD8-MGATP-UBC12(C111A), A TRAPPED UBIQUITIN-LIKE PROTEIN ACTIVATION COMPLEX
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, NEDD8-conjugating enzyme Ubc12, ...
Authors:Huang, D.T., Hunt, H.W., Zhuang, M., Ohi, M.D., Holton, J.M., Schulman, B.A.
Deposit date:2006-11-13
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445, 2007
3DBH
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STRUCTURAL DISSECTION OF A GATING MECHANISM PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8'S E1 (APPBP1-UBA3ARG190ALA-NEDD8ALA72ARG)
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ...
Authors:Souphron, J., Schulman, B.A.
Deposit date:2008-05-31
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008
3DBL
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STRUCTURAL DISSECTION OF A GATING MECHANISM PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8'S E1 (APPBP1-UBA3ARG190WT-NEDD8ALA72GLN)
Descriptor:NEDD8-activating enzyme E1 regulatory subunit, NEDD8-activating enzyme E1 catalytic subunit, NEDD8, ...
Authors:Souphron, J., Schulman, B.A.
Deposit date:2008-06-01
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Biochemistry, 47, 2008