Author results

1EYN
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STRUCTURE OF MURA LIGANDED WITH THE EXTRINSIC FLUORESCENCE PROBE ANS
Descriptor:UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE, 8-ANILINO-1-NAPHTHALENE SULFONATE, GLYCEROL
Authors:Schonbrunn, E., Eschenburg, S., Luger, K., Kabsch, W., Amrhein, N.
Deposit date:2000-05-07
Release date:2000-06-09
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA.
Proc.Natl.Acad.Sci.USA, 97, 2000
1DLG
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CRYSTAL STRUCTURE OF THE C115S ENTEROBACTER CLOACAE MURA IN THE UN-LIGANDED STATE
Descriptor:UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE MURA, PHOSPHATE ION, CYCLOHEXYLAMMONIUM ION
Authors:Schonbrunn, E., Eschenburg, S., Krekel, F., Luger, K., Amrhein, N.
Deposit date:1999-12-09
Release date:2000-04-12
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA.
Biochemistry, 39, 2000
1G6S
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STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE AND GLYPHOSATE
Descriptor:EPSP SYNTHASE, SHIKIMATE-3-PHOSPHATE, GLYPHOSATE, ...
Authors:Schonbrunn, E., Eschenburg, S., Shuttleworth, W., Schloss, J.V., Amrhein, N., Evans, J.N.S., Kabsch, W.
Deposit date:2000-11-07
Release date:2001-02-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.
Proc.Natl.Acad.Sci.USA, 98, 2001
1G6T
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STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE
Descriptor:EPSP SYNTHASE, PHOSPHATE ION, SHIKIMATE-3-PHOSPHATE, ...
Authors:Schonbrunn, E., Eschenburg, S., Shuttleworth, W., Schloss, J.V., Amrhein, N., Evans, J.N.S., Kabsch, W.
Deposit date:2000-11-07
Release date:2001-02-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.
Proc.Natl.Acad.Sci.USA, 98, 2001
3FJX
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E. COLI EPSP SYNTHASE (T97I) LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, FORMIC ACID
Authors:Schonbrunn, E.
Deposit date:2008-12-15
Release date:2009-02-17
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 -> Ile and Pro101 -> Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli.
J.Biol.Chem., 284, 2009
3FJZ
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E. COLI EPSP SYNTHASE (T97I) LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SERINE, N-(phosphonomethyl)glycine, ...
Authors:Schonbrunn, E.
Deposit date:2008-12-15
Release date:2009-02-17
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 -> Ile and Pro101 -> Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli.
J.Biol.Chem., 284, 2009
3FK1
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E. COLI EPSP SYNTHASE (TIPS MUTATION) LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, N-(phosphonomethyl)glycine, ...
Authors:Schonbrunn, E.
Deposit date:2008-12-15
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 -> Ile and Pro101 -> Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli.
J.Biol.Chem., 284, 2009
2QFQ
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E. COLI EPSP SYNTHASE PRO101LEU LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, FORMIC ACID
Authors:Schonbrunn, E., Healy-Fried, M.L.
Deposit date:2007-06-27
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J.Biol.Chem., 282, 2007
3FK0
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E. COLI EPSP SYNTHASE (TIPS MUTATION) LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, FORMIC ACID
Authors:Schonbrunn, E.
Deposit date:2008-12-15
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 -> Ile and Pro101 -> Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli.
J.Biol.Chem., 284, 2009
3LTH
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E. CLOACAE MURA DEAD-END COMPLEX WITH UNAG AND FOSFOMYCIN
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, [(1R)-1-hydroxypropyl]phosphonic acid, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Schonbrunn, E.
Deposit date:2010-02-15
Release date:2010-05-05
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .
Biochemistry, 49, 2010
2GG4
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CP4 EPSP SYNTHASE (UNLIGANDED)
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GG6
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CP4 EPSP SYNTHASE LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SULFATE ION, SHIKIMATE-3-PHOSPHATE
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GGA
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CP4 EPSP SYNTHASE LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, GLYPHOSATE
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GGD
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CP4 EPSP SYNTHASE ALA100GLY LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, GLYPHOSATE
Authors:Schonbrunn, E., Funke, T.
Deposit date:2006-03-23
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis for the herbicide resistance of Roundup Ready crops.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2QFS
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E.COLI EPSP SYNTHASE PRO101SER LIGANDED WITH S3P
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, SHIKIMATE-3-PHOSPHATE, FORMIC ACID
Authors:Schonbrunn, E., Healy-Fried, M.L.
Deposit date:2007-06-28
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J.Biol.Chem., 282, 2007
2QFT
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E.COLI EPSP SYNTHASE PRO101SER LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, GLYPHOSATE, SHIKIMATE-3-PHOSPHATE, ...
Authors:Schonbrunn, E., Healy-Fried, M.L.
Deposit date:2007-06-28
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J.Biol.Chem., 282, 2007
2QFU
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E.COLI EPSP SYNTHASE PRO101LEU LIGANDED WITH S3P AND GLYPHOSATE
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, GLYPHOSATE, SHIKIMATE-3-PHOSPHATE, ...
Authors:Schonbrunn, E., Healy-Fried, M.L.
Deposit date:2007-06-28
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of glyphosate tolerance resulting from mutations of Pro101 in Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase.
J.Biol.Chem., 282, 2007
3ELL
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STRUCTURE OF THE HEMOPHORE FROM PSEUDOMONAS AERUGINOSA (HASAP)
Descriptor:HasAp (Heme acquisition protein HasAp), PROTOPORPHYRIN IX CONTAINING FE
Authors:Schonbrunn, E., Rivera, M.
Deposit date:2008-09-22
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural characterization of the hemophore HasAp from Pseudomonas aeruginosa: NMR spectroscopy reveals protein-protein interactions between Holo-HasAp and hemoglobin.
Biochemistry, 48, 2009
3JZO
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HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE (PDI)
Descriptor:Protein Mdm4, pDI peptide (12mer), POTASSIUM ION
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-23
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZP
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HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDI6W)
Descriptor:Protein Mdm4, pDI6W peptide (12mer), POTASSIUM ION
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZQ
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HUMAN MDMX LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDIQ)
Descriptor:Protein Mdm4, pDIQ peptide (12mer), SULFATE ION
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZR
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HUMAN MDM2 LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDI6W)
Descriptor:E3 ubiquitin-protein ligase Mdm2, pDI6W peptide (12mer)
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3JZS
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HUMAN MDM2 LIGANDED WITH A 12MER PEPTIDE INHIBITOR (PDIQ)
Descriptor:E3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer), 1,2-ETHANEDIOL
Authors:Schonbrunn, E., Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010
3KQA
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MURA DEAD-END COMPLEX WITH TERREIC ACID
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, (5S)-2,5-dihydroxy-3-methylcyclohex-2-ene-1,4-dione, CALCIUM ION
Authors:Schonbrunn, E.
Deposit date:2009-11-17
Release date:2010-04-28
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .
Biochemistry, 49, 2010
3KQJ
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MURA BINARY COMPLEX WITH UDP-N-ACETYLGLUCOSAMINE
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, GLYCEROL, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ...
Authors:Schonbrunn, E.
Deposit date:2009-11-17
Release date:2010-04-28
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Natural Product Antibiotic Terreic Acid is a Mechanism-Based Inhibitor of the Bacterial Enzyme MurA in vitro but not in vivo.
To be Published