Author results

1FQ9
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CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, ...
Authors:Schlessinger, J., Plotnikov, A.N., Ibrahimi, O.A., Eliseenkova, A.V., Yeh, B.K., Yayon, A., Linhardt, R.J., Mohammadi, M.
Deposit date:2000-09-04
Release date:2000-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Mol.Cell, 6, 2000
6NFJ
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STRUCTURE OF BETA-KLOTHO IN COMPLEX WITH FGF19 C-TERMINAL PEPTIDE
Descriptor:Beta-klotho, Nanobody 30, Fibroblast growth factor 19
Authors:Kuzina, E., Schlessinger, J., Lee, S.
Deposit date:2018-12-20
Release date:2019-04-03
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1DCQ
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CRYSTAL STRUCTURE OF THE ARF-GAP DOMAIN AND ANKYRIN REPEATS OF PAPBETA.
Descriptor:PYK2-ASSOCIATED PROTEIN BETA, ZINC ION
Authors:Mandiyan, V., Andreev, J., Schlessinger, J., Hubbard, S.R.
Deposit date:1999-11-05
Release date:1999-12-22
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta.
EMBO J., 18, 1999
1AGW
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-25
Release date:1998-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1FGI
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-22
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1T9R
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, PHOSPHATE ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-18
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1T9S
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH GMP
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-18
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TAZ
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 1B
Descriptor:Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TB5
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TB7
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TBB
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROLIPRAM
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-19
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
1TBF
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 5A IN COMPLEX WITH SILDENAFIL
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Zhang, K.Y.J., Card, G.L., Suzuki, Y., Artis, D.R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B.L., Zhang, C., Milburn, M.V., Kim, S.-H., Schlessinger, J., Bollag, G.
Deposit date:2004-05-20
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15, 2004
5VAK
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CRYSTAL STRUCTURE OF BETA-KLOTHO, DOMAIN 1
Descriptor:Beta-klotho, Nb914, N-ACETYL-D-GLUCOSAMINE
Authors:Lee, S., Schlessinger, J.
Deposit date:2017-03-27
Release date:2018-01-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
5VAN
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CRYSTAL STRUCTURE OF BETA-KLOTHO
Descriptor:Beta-klotho, Nb914, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lee, S., Schlessinger, J.
Deposit date:2017-03-27
Release date:2018-01-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
5VAQ
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CRYSTAL STRUCTURE OF BETA-KLOTHO IN COMPLEX WITH FGF21CT
Descriptor:Beta-klotho, Nb914, Fibroblast growth factor 21, ...
Authors:Lee, S., Schlessinger, J.
Deposit date:2017-03-27
Release date:2018-01-31
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.606 Å)
Cite:Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
1AXM
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HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
Descriptor:ACIDIC FIBROBLAST GROWTH FACTOR, N,O6-DISULFO-GLUCOSAMINE, 2-O-sulfo-alpha-L-idopyranuronic acid
Authors:DiGabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Hendrickson, W.A.
Deposit date:1997-10-16
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
2AXM
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HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
Descriptor:ACIDIC FIBROBLAST GROWTH FACTOR, N,O6-DISULFO-GLUCOSAMINE, 2-O-sulfo-alpha-L-idopyranuronic acid
Authors:Digabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Hendrickson, W.A.
Deposit date:1997-10-20
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
2FGI
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1), 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA
Authors:Mohammadi, M., Froum, S., Hamby, J.M., Schroeder, M., Panek, R.L., Lu, G.H., Eliseenkova, A.V., Green, D., Schlessinger, J., Hubbard, S.R.
Deposit date:1998-09-15
Release date:1999-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
EMBO J., 17, 1998
3GM1
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CRYSTAL STRUCTURE OF THE FOCAL ADHESION TARGETING (FAT) DOMAIN OF PYK2 IN COMPLEX WITH PAXILLIN LD4 MOTIF-DERIVED PEPTIDES
Descriptor:Protein tyrosine kinase 2 beta, Paxillin
Authors:Lulo, J.E., Yuzawa, S., Schlessinger, J.
Deposit date:2009-03-12
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Biochem.Biophys.Res.Commun., 383, 2009
3GM2
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CRYSTAL STRUCTURE OF THE FOCAL ADHESION TARGETING (FAT) DOMAIN OF PYK2
Descriptor:Protein tyrosine kinase 2 beta
Authors:Lulo, J.E., Yuzawa, S., Schlessinger, J.
Deposit date:2009-03-12
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Biochem.Biophys.Res.Commun., 383, 2009
3GM3
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CRYSTAL STRUCTURE OF THE FOCAL ADHESION TARGETING (FAT) DOMAIN OF PYK2
Descriptor:Protein tyrosine kinase 2 beta
Authors:Lulo, J.E., Yuzawa, S., Schlessinger, J.
Deposit date:2009-03-12
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Biochem.Biophys.Res.Commun., 383, 2009
1CVS
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CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION
Authors:Plotnikov, A.N., Schlessinger, J., Hubbard, S.R., Mohammadi, M.
Deposit date:1999-08-24
Release date:2000-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98, 1999
1DYN
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CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM HUMAN DYNAMIN
Descriptor:DYNAMIN
Authors:Ferguson, K.M., Lemmon, M.A., Schlessinger, J., Sigler, P.B.
Deposit date:1994-12-21
Release date:1995-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin.
Cell(Cambridge,Mass.), 79, 1994
1EV2
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CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-19
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1EVT
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CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-20
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000