1FCC
 
 | | CRYSTAL STRUCTURE OF THE C2 FRAGMENT OF STREPTOCOCCAL PROTEIN G IN COMPLEX WITH THE FC DOMAIN OF HUMAN IGG | | Descriptor: | IGG1 MO61 FC, STREPTOCOCCAL PROTEIN G (C2 FRAGMENT) | | Authors: | Sauer-Eriksson, A.E, Kleywegt, G.J, Uhlen, M, Jones, T.A. | | Deposit date: | 1995-01-17 | | Release date: | 1995-04-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG.
Structure, 3, 1995
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4M8O
 | | TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-AMINOETHANESULFONIC ACID, CHLORIDE ION, ... | | Authors: | Sauer-Eriksson, A.E, Hogg, M, Osterman, P, Johansson, E. | | Deposit date: | 2013-08-13 | | Release date: | 2013-11-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon.
Nat.Struct.Mol.Biol., 21, 2014
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2QEL
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7OB4
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3M8J
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4QXV
 | | CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION | | Descriptor: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, GLYCEROL, SODIUM ION, ... | | Authors: | Begum, A, Olofsson, A, Sauer-Eriksson, A.E. | | Deposit date: | 2014-07-22 | | Release date: | 2015-06-03 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
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4QYA
 | | Crystal structure of human transthyretin variant V30M in complex with luteolin | | Descriptor: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, Transthyretin | | Authors: | Begum, A, Olofsson, A, Sauer-Eriksson, A.E. | | Deposit date: | 2014-07-24 | | Release date: | 2015-06-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
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2V3C
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5JID
 | | Crystal Structure of Human Transthyretin in Complex with Perfluorooctanoic acid (PFOA) | | Descriptor: | SODIUM ION, Transthyretin, pentadecafluorooctanoic acid | | Authors: | Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. | | Deposit date: | 2016-04-22 | | Release date: | 2016-10-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
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5JIQ
 | | Crystal Structure of Human Transthyretin in Complex with 2,2',4,4'-tetrahydroxybenzophenone (BP2) | | Descriptor: | GLYCEROL, SODIUM ION, Transthyretin, ... | | Authors: | Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. | | Deposit date: | 2016-04-22 | | Release date: | 2016-10-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
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5JIM
 | | Crystal Structure of Human Transthyretin in Complex with Perfluoroktansulfonsyra (PFOS) | | Descriptor: | SODIUM ION, Transthyretin, heptadecafluoro-1-octanesulfonic acid | | Authors: | Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. | | Deposit date: | 2016-04-22 | | Release date: | 2016-10-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
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5BOJ
 | | Crystal Structure of Human Transthyretin in Complex with Gemfibrozil | | Descriptor: | 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid, SODIUM ION, Transthyretin | | Authors: | Begum, A, Olofsson, A, Sauer-Eriksson, A.E. | | Deposit date: | 2015-05-27 | | Release date: | 2015-08-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma.
J.Med.Chem., 58, 2015
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5EJE
 | | Crystal structure of E. coli Adenylate kinase G56C/T163C double mutant in complex with Ap5a | | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, COBALT (II) ION | | Authors: | Sauer, U.H, Kovermann, M, Grundstrom, C, Wolf-Watz, M, Sauer-Eriksson, A.E. | | Deposit date: | 2015-11-01 | | Release date: | 2016-11-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for ligand binding to an enzyme by a conformational selection pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5EN3
 | | Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution | | Descriptor: | 2-[3,4-bis(oxidanyl)phenyl]-7-chloranyl-5-oxidanyl-chromen-4-one, GLYCEROL, SODIUM ION, ... | | Authors: | Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E. | | Deposit date: | 2015-11-09 | | Release date: | 2016-04-20 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.
Plos One, 11, 2016
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5F1R
 | | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (C10) | | Descriptor: | (3~{R})-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, Listeriolysin regulatory protein | | Authors: | Begum, A, Grundstrom, C, Good, J.A.D, Andersson, C, ALmqvist, F, Johansson, J, Sauer, U.H, Sauer-Eriksson, A.E. | | Deposit date: | 2015-11-30 | | Release date: | 2016-03-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.
Cell Chem Biol, 23, 2016
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6ZJD
 | | Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, GTP:AMP phosphotransferase AK3, ... | | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | | Deposit date: | 2020-06-28 | | Release date: | 2020-09-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3.
Biochemistry, 59, 2020
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6ZJB
 | | Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor Gp5A | | Descriptor: | GTP:AMP phosphotransferase AK3, mitochondrial, MAGNESIUM ION, ... | | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | | Deposit date: | 2020-06-28 | | Release date: | 2020-09-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.822 Å) | | Cite: | Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3.
Biochemistry, 59, 2020
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6ZJE
 | | Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor Ap5A | | Descriptor: | BIS(ADENOSINE)-5'-PENTAPHOSPHATE, CHLORIDE ION, GTP:AMP phosphotransferase AK3, ... | | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | | Deposit date: | 2020-06-28 | | Release date: | 2020-09-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3.
Biochemistry, 59, 2020
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4XCO
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4L9D
 | | Crystal structure of the PKD1 domain from Vibrio cholerae metalloprotease PrtV | | Descriptor: | CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Edwin, A, Stier, G, Sauer-Eriksson, A.E. | | Deposit date: | 2013-06-18 | | Release date: | 2013-07-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Calcium binding by the PKD1 domain regulates interdomain flexibility in Vibrio cholerae metalloprotease PrtV.
FEBS Open Bio, 3, 2013
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1LNG
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8C7O
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8C7U
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8C7T
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8C7S
 | | Transcriptional pleiotropic repressor CodY from Staphylococcus aureus in complex with Ile, GTP, and a 30-bp DNA fragment encompassing two overlapping binding sites | | Descriptor: | DNA (30-MER), GUANOSINE-5'-TRIPHOSPHATE, Global transcriptional regulator CodY (Fragment), ... | | Authors: | Hainzl, T, Sauer-Eriksson, A.E. | | Deposit date: | 2023-01-17 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
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