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1FCC
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BU of 1fcc by Molmil
CRYSTAL STRUCTURE OF THE C2 FRAGMENT OF STREPTOCOCCAL PROTEIN G IN COMPLEX WITH THE FC DOMAIN OF HUMAN IGG
Descriptor: IGG1 MO61 FC, STREPTOCOCCAL PROTEIN G (C2 FRAGMENT)
Authors:Sauer-Eriksson, A.E, Kleywegt, G.J, Uhlen, M, Jones, T.A.
Deposit date:1995-01-17
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG.
Structure, 3, 1995
4M8O
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BU of 4m8o by Molmil
TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-AMINOETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Sauer-Eriksson, A.E, Hogg, M, Osterman, P, Johansson, E.
Deposit date:2013-08-13
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon.
Nat.Struct.Mol.Biol., 21, 2014
2QEL
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BU of 2qel by Molmil
Crystal structure of the highly amyloidogenic transthyretin mutant TTR G53S/E54D/L55S- heated protein
Descriptor: Transthyretin
Authors:Karlsson, A, Sauer-Eriksson, A.E.
Deposit date:2007-06-26
Release date:2007-09-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Heating of proteins as a means of improving crystallization: a successful case study on a highly amyloidogenic triple mutant of human transthyretin
Acta Crystallogr.,Sect.F, 63, 2007
1SN0
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BU of 1sn0 by Molmil
Crystal Structure Of Sea Bream Transthyretin in complex with thyroxine At 1.9A Resolution
Descriptor: 3,5,3',5'-TETRAIODO-L-THYRONINE, SULFATE ION, transthyretin
Authors:Eneqvist, T, Lundberg, E, Karlsson, A, Huang, S, Santos, C.R, Power, D.M, Sauer-Eriksson, A.E.
Deposit date:2004-03-10
Release date:2004-08-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.
J.Biol.Chem., 279, 2004
4QXV
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BU of 4qxv by Molmil
CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, GLYCEROL, SODIUM ION, ...
Authors:Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2014-07-22
Release date:2015-06-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
4QYA
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BU of 4qya by Molmil
Crystal structure of human transthyretin variant V30M in complex with luteolin
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, Transthyretin
Authors:Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2014-07-24
Release date:2015-06-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
3M8J
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BU of 3m8j by Molmil
Crystal structure of E.coli FocB at 1.4 A resolution
Descriptor: FocB protein
Authors:Hultdin, U.W, Huang, S, Sauer-Eriksson, A.E.
Deposit date:2010-03-18
Release date:2010-08-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of FocB - a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli
Febs J., 277, 2010
2V3C
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BU of 2v3c by Molmil
Crystal structure of the SRP54-SRP19-7S.S SRP RNA complex of M. jannaschii
Descriptor: 7S RNA, SIGNAL RECOGNITION 54 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN
Authors:Hainzl, T, Huang, S, Sauer-Eriksson, A.E.
Deposit date:2007-06-15
Release date:2007-09-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interaction of Signal-Recognition Particle 54 Gtpase Domain and Signal-Recognition Particle RNA in the Free Signal-Recognition Particle.
Proc.Natl.Acad.Sci.USA, 104, 2007
5JID
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BU of 5jid by Molmil
Crystal Structure of Human Transthyretin in Complex with Perfluorooctanoic acid (PFOA)
Descriptor: SODIUM ION, Transthyretin, pentadecafluorooctanoic acid
Authors:Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E.
Deposit date:2016-04-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
5JIQ
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BU of 5jiq by Molmil
Crystal Structure of Human Transthyretin in Complex with 2,2',4,4'-tetrahydroxybenzophenone (BP2)
Descriptor: GLYCEROL, SODIUM ION, Transthyretin, ...
Authors:Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E.
Deposit date:2016-04-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
5JIM
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BU of 5jim by Molmil
Crystal Structure of Human Transthyretin in Complex with Perfluoroktansulfonsyra (PFOS)
Descriptor: SODIUM ION, Transthyretin, heptadecafluoro-1-octanesulfonic acid
Authors:Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E.
Deposit date:2016-04-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
6T5I
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BU of 6t5i by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with inhibitor of WNT production (IWP)-2
Descriptor: DIMETHYL SULFOXIDE, Listeriolysin positive regulatory factor A, SODIUM ION, ...
Authors:Oelker, M, Grundstrom, C, Blumenthal, A, Sauer-Eriksson, A.E.
Deposit date:2019-10-16
Release date:2021-10-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
Plos Pathog., 18, 2022
7OB4
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BU of 7ob4 by Molmil
Cryo-EM structure of a twisted-dimer transthyretin amyloid fibril from vitreous body of the eye
Descriptor: Transthyretin
Authors:Iakovleva, I, Sauer-Eriksson, A.E.
Deposit date:2021-04-21
Release date:2021-12-15
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural basis for transthyretin amyloid formation in vitreous body of the eye.
Nat Commun, 12, 2021
4L9D
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BU of 4l9d by Molmil
Crystal structure of the PKD1 domain from Vibrio cholerae metalloprotease PrtV
Descriptor: CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Edwin, A, Stier, G, Sauer-Eriksson, A.E.
Deposit date:2013-06-18
Release date:2013-07-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Calcium binding by the PKD1 domain regulates interdomain flexibility in Vibrio cholerae metalloprotease PrtV.
FEBS Open Bio, 3, 2013
8C7O
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BU of 8c7o by Molmil
Unliganded transcriptional pleiotropic repressor CodY from Staphylococcus aureus
Descriptor: ACETATE ION, Global transcriptional regulator CodY, SULFATE ION
Authors:Hainzl, T, Sauer-Eriksson, A.E.
Deposit date:2023-01-16
Release date:2023-06-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
8C7U
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BU of 8c7u by Molmil
Transcriptional pleiotropic repressor CodY from Enterococcus faecalis in complex with Leu and a 30-bp DNA fragment encompassing two overlapping binding sites
Descriptor: DNA (29-MER), DNA (30-MER), GTP-sensing transcriptional pleiotropic repressor CodY, ...
Authors:Hainzl, T, Sauer-Eriksson, A.E.
Deposit date:2023-01-17
Release date:2023-06-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
8C7T
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BU of 8c7t by Molmil
Unliganded transcriptional pleiotropic repressor CodY from Enterococcus faecalis
Descriptor: GTP-sensing transcriptional pleiotropic repressor CodY
Authors:Hainzl, T, Sauer-Eriksson, A.E.
Deposit date:2023-01-17
Release date:2023-06-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
8C7S
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BU of 8c7s by Molmil
Transcriptional pleiotropic repressor CodY from Staphylococcus aureus in complex with Ile, GTP, and a 30-bp DNA fragment encompassing two overlapping binding sites
Descriptor: DNA (30-MER), GUANOSINE-5'-TRIPHOSPHATE, Global transcriptional regulator CodY (Fragment), ...
Authors:Hainzl, T, Sauer-Eriksson, A.E.
Deposit date:2023-01-17
Release date:2023-07-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural insights into CodY activation and DNA recognition.
Nucleic Acids Res., 51, 2023
8CRG
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BU of 8crg by Molmil
E. coli adenylate kinase in complex with two ADP molecules as a result of enzymatic AP4A hydrolysis
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, Adenylate kinase
Authors:Oelker, M, Tischlik, S, Wolf-Watz, M, Sauer-Eriksson, A.E.
Deposit date:2023-03-08
Release date:2023-06-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Insights into Enzymatic Catalysis from Binding and Hydrolysis of Diadenosine Tetraphosphate by E. coli Adenylate Kinase.
Biochemistry, 62, 2023
5BOJ
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BU of 5boj by Molmil
Crystal Structure of Human Transthyretin in Complex with Gemfibrozil
Descriptor: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid, SODIUM ION, Transthyretin
Authors:Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2015-05-27
Release date:2015-08-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma.
J.Med.Chem., 58, 2015
5EJE
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BU of 5eje by Molmil
Crystal structure of E. coli Adenylate kinase G56C/T163C double mutant in complex with Ap5a
Descriptor: Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, COBALT (II) ION
Authors:Sauer, U.H, Kovermann, M, Grundstrom, C, Wolf-Watz, M, Sauer-Eriksson, A.E.
Deposit date:2015-11-01
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for ligand binding to an enzyme by a conformational selection pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5EN3
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BU of 5en3 by Molmil
Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution
Descriptor: 2-[3,4-bis(oxidanyl)phenyl]-7-chloranyl-5-oxidanyl-chromen-4-one, GLYCEROL, SODIUM ION, ...
Authors:Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2015-11-09
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.
Plos One, 11, 2016
5F1R
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BU of 5f1r by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (C10)
Descriptor: (3~{R})-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, Listeriolysin regulatory protein
Authors:Begum, A, Grundstrom, C, Good, J.A.D, Andersson, C, ALmqvist, F, Johansson, J, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2015-11-30
Release date:2016-03-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.
Cell Chem Biol, 23, 2016
4XCO
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BU of 4xco by Molmil
Signal-sequence induced conformational changes in the signal recognition particle
Descriptor: MAGNESIUM ION, RNA, SODIUM ION, ...
Authors:Hainzl, T, Sauer-Eriksson, A.E.
Deposit date:2014-12-18
Release date:2015-06-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Signal-sequence induced conformational changes in the signal recognition particle.
Nat Commun, 6, 2015
6EXM
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BU of 6exm by Molmil
The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (MK202)
Descriptor: ISOPROPYL ALCOHOL, Listeriolysin positive regulatory factor A, SODIUM ION, ...
Authors:Grundstrom, C, Begum, A, Hall, M, Kulen, M, Lindgren, M, Johansson, J, Almqvist, F, Sauer, U.H, Sauer-Eriksson, A.E.
Deposit date:2017-11-08
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018

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