Author results

1J5O
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CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER
分子名称:5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3', Reverse transcriptase, ...
著者Sarafianos, S.G., Das, K., Arnold, E.
登録日2002-05-24
公開日2002-06-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QE1
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CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
分子名称:REVERSE TRANSCRIPTASE, SUBUNIT P66, SUBUNIT P51
著者Sarafianos, S.G., Das, K., Ding, J., Hughes, S.H., Arnold, E.
登録日1999-07-12
公開日1999-08-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96, 1999
1HYS
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
分子名称:5'-R(*UP*CP*AP*GP*CP*CP*AP*CP*UP*UP*UP*UP*UP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3', 5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*GP*TP*GP*GP*CP*TP*G)-3', HIV-1 REVERSE TRANSCRIPTASE, ...
著者Sarafianos, S.G., Das, K., Tantillo, C., Clark Jr., A.D., Ding, J., Whitcomb, J., Boyer, P.L., Hughes, S.H., Arnold, E.
登録日2001-01-22
公開日2001-03-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
EMBO J., 20, 2001
1N5Y
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX P)
分子名称:5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3', REVERSE TRANSCRIPTASE, ...
著者Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, P., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E.
登録日2002-11-07
公開日2003-01-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of HIV-1 Reverse Transcriptase with Pre-Translocation and Post-Translocation AZTMP-Terminated DNA
Embo J., 21, 2002
1N6Q
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO PRE-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX N)
分子名称:5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*AP*(ATM))-3', Reverse Transcriptase, ...
著者Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, I., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E.
登録日2002-11-11
公開日2003-01-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of HIV-1 Reverse Transcriptase with Pre- and Post-translocation AZTMP-terminated DNA
Embo J., 21, 2002
3NTC
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CRYSTAL STRUCTURE OF KD-247 FAB, AN ANTI-V3 ANTIBODY THAT INHIBITS HIV-1 ENTRY
分子名称:Fab light chain, Fab heavy chain, SULFATE ION, ...
著者Sarafianos, S.G., Kirby, K.A.
登録日2010-07-03
公開日2010-08-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structure of KD-247 Fab, an anti-V3 antibody that inhibits HIV-1 Entry
To be Published
2I5J
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH DHBNH, AN RNASE H INHIBITOR
分子名称:Reverse transcriptase/ribonuclease H P66 subunit, Reverse transcriptase/ribonuclease H P51 subunit, ALPHA-D-GLUCOSE, ...
著者Himmel, D.M., Sarafianos, S.G., Knight, J.L., Levy, R.M., Arnold, E.
登録日2006-08-24
公開日2006-12-05
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
Acs Chem.Biol., 1, 2006
1T03
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TENOFOVIR TERMINATED TEMPLATE-PRIMER (COMPLEX P)
分子名称:Synthetic oligonucleotide template, Synthetic oligonucleotide primer, POL polyprotein, ...
著者Tuske, S., Sarafianos, S.G., Ding, J., Arnold, E.
登録日2004-04-07
公開日2004-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol., 11, 2004
1T05
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TEMPLATE-PRIMER WITH TENOFOVIR-DIPHOSPHATE BOUND AS THE INCOMING NUCLEOTIDE SUBSTRATE
分子名称:oligonucleotide template, oligonucleotide primer, POL polyprotein, ...
著者Tuske, S., Sarafianos, S.G., Ding, J., Arnold, E.
登録日2004-04-07
公開日2004-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol., 11, 2004
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
分子名称:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase subunit beta' chain, ...
著者Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
登録日2005-06-10
公開日2005-09-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
分子名称:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
著者Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
登録日2005-06-15
公開日2005-09-20
最終更新日2012-09-05
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3KLE
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CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, DNA (25-MER), ...
著者Tu, X., Das, K., Sarafianos, S.G., Arnold, E.
登録日2009-11-07
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLF
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CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, DNA (5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ...
著者Tu, X., Das, K., Sarafianos, S.G., Arnold, E.
登録日2009-11-07
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLG
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CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO PRE-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX N)
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, DNA (5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ...
著者Tu, X., Sarafianos, S.G., Arnold, E.
登録日2009-11-07
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLH
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CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX P)
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, monoclonal antibody, ...
著者Tu, X., Sarafianos, S.G., Arnold, E.
登録日2009-11-07
公開日2010-09-22
最終更新日2013-09-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLI
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CRYSTAL STRUCTURE OF UNLIGANDED AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE
分子名称:Reverse transcriptase/ribonuclease H, p51 RT
著者Tu, X., Sarafianos, S.G., Arnold, E.
登録日2009-11-08
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3P1G
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CRYSTAL STRUCTURE OF THE XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS (XMRV) RNASE H DOMAIN
分子名称:Xenotropic Murine Leukemia Virus-Related Virus (XMRV) RNase H Domain, MAGNESIUM ION
著者Kirby, K.A., Sarafianos, S.G.
登録日2010-09-30
公開日2010-10-13
最終更新日2012-04-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase.
Antimicrob.Agents Chemother., 56, 2012
4DG1
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) WITH POLYMORPHISM MUTATION K172A AND K173A
分子名称:Reverse Transcriptase P66 subunit, Reverse Transcriptase P51 subunit, MAGNESIUM ION, ...
著者Tu, X., Kirby, K.A., Marchand, B., Sarafianos, S.G.
登録日2012-01-24
公開日2012-06-20
最終更新日2012-09-12
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors.
J.Biol.Chem., 287, 2012
4XFX
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN
分子名称:HIV-1 capsid protein, IODIDE ION, CHLORIDE ION
著者Gres, A.T., Kirby, K.A., Sarafianos, S.G.
登録日2014-12-29
公開日2015-06-10
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science, 349, 2015
4XFY
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STRUCTURE OF THE NATIVE FULL-LENGTH DEHYDRATED HIV-1 CAPSID PROTEIN
分子名称:HIV-1 capsid protein, CHLORIDE ION, PENTAETHYLENE GLYCOL
著者Gres, A.T., Kirby, K.A., Sarafianos, S.G.
登録日2014-12-29
公開日2015-06-10
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science, 349, 2015
4XFZ
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH PF-3450074 (PF74)
分子名称:HIV-1 capsid protein, IODIDE ION, CHLORIDE ION, ...
著者Gres, A.T., Kirby, K.A., Sarafianos, S.G.
登録日2014-12-29
公開日2015-06-10
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science, 349, 2015
5HBM
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CRYSTAL STRUCTURE OF A DIHYDROXYCOUMARIN RNASE H ACTIVE-SITE INHIBITOR IN COMPLEX WITH HIV-1 REVERSE TRANSCRIPTASE
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ...
著者Kirby, K.A., Sarafianos, S.G.
登録日2015-12-31
公開日2016-02-24
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (3.043 Å)
主引用文献Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase
To Be Published
5J1E
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CRYSTAL STRUCTURE OF A HYDROXYPYRIDONE CARBOXYLIC ACID ACTIVE-SITE RNASE H INHIBITOR IN COMPLEX WITH HIV REVERSE TRANSCRIPTASE
分子名称:HIV-1 REVERSE TRANSCRIPTASE P66 DOMAIN, HIV-1 REVERSE TRANSCRIPTASE P51 DOMAIN, MAGNESIUM ION, ...
著者Kirby, K.A., Sarafianos, S.G.
登録日2016-03-29
公開日2016-06-15
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.
J.Med.Chem., 59, 2016
5J2M
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HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA AND EFDA-TRIPHOSPHATE, A TRANSLOCATION-DEFECTIVE RT INHIBITOR
分子名称:HIV-1 reverse transcriptase p51 subunit, DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), DNA (27-MER), ...
著者Salie, Z.L., Kirby, K.A., Sarafianos, S.G.
登録日2016-03-29
公開日2016-08-03
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.432 Å)
主引用文献Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc.Natl.Acad.Sci.USA, 113, 2016
5J2N
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HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA THAT HAS INCORPORATED EFDA-MP AT THE P-(POST-TRANSLOCATION) SITE AND DTMP AT THE N-(PRE-TRANSLOCATION) SITE
分子名称:reverse transcriptase, p66 domain, p51 domain, ...
著者Salie, Z.L., Kirby, K.A., Sarafianos, S.G.
登録日2016-03-29
公開日2016-08-03
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.896 Å)
主引用文献Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc.Natl.Acad.Sci.USA, 113, 2016