Author results

1HZH
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CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN
Descriptor:IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Saphire, E.O., Burton, D.R., Wilson, I.A.
Deposit date:2001-01-24
Release date:2001-08-15
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science, 293, 2001
1N0X
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CRYSTAL STRUCTURE OF A BROADLY NEUTRALIZING ANTI-HIV-1 ANTIBODY IN COMPLEX WITH A PEPTIDE MIMOTOPE
Descriptor:IMMUNOGLOBULIN LIGHT CHAIN, IMMUNOGLOBULIN HEAVY CHAIN, B2.1 peptide, ...
Authors:Saphire, E.O., Montero, M., Menendez, A., Irving, M.B., Zwick, M.B., Parren, P.W.H.I., Burton, D.R., Scott, J.K., Wilson, I.A.
Deposit date:2002-10-15
Release date:2004-04-13
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope
To be Published
3S88
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CRYSTAL STRUCTURE OF SUDAN EBOLAVIRUS GLYCOPROTEIN (STRAIN GULU) BOUND TO 16F6
Descriptor:16F6 - Heavy chain, Envelope glycoprotein, 16F6 - Light chain, ...
Authors:Saphire, E.O., Dias, J.M., Bale, S.
Deposit date:2011-05-27
Release date:2011-12-07
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (3.351 Å)
Cite:A shared structural solution for neutralizing ebolaviruses.
Nat.Struct.Mol.Biol., 18, 2011
3VE0
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CRYSTAL STRUCTURE OF SUDAN EBOLAVIRUS GLYCOPROTEIN (STRAIN BONIFACE) BOUND TO 16F6
Descriptor:Envelope glycoprotein, 16F6 Antibody chain A, 16F6 Antibody chain B, ...
Authors:Saphire, E.O., Bale, S., Dias, J.M.
Deposit date:2012-01-06
Release date:2012-04-18
Last modified:2012-05-30
Method:X-RAY DIFFRACTION (3.353 Å)
Cite:Structural basis for differential neutralization of ebolaviruses.
Viruses, 4, 2012
2QHR
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CRYSTAL STRUCTURE OF THE 13F6-1-2 FAB FRAGMENT BOUND TO ITS EBOLA VIRUS GLYCOPROTEIN PEPTIDE EPITOPE.
Descriptor:13F6-1-2 Fab fragment heavy chain, 13F6-1-2 Fab fragment V lambda x light chain, Envelope glycoprotein peptide
Authors:Lee, J.E., Kuehne, A., Abelson, D.M., Fusco, M.L., Hart, M.K., Saphire, E.O.
Deposit date:2007-07-02
Release date:2008-01-22
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.
J.Mol.Biol., 375, 2008
2Y6S
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STRUCTURE OF AN EBOLAVIRUS-PROTECTIVE ANTIBODY IN COMPLEX WITH ITS MUCIN-DOMAIN LINEAR EPITOPE
Descriptor:LIGHT CHAIN, HEAVY CHAIN, ENVELOPE GLYCOPROTEIN
Authors:Olal, D.O., Kuehne, A., Lee, J.E., Bale, S., Dye, J.M., Saphire, E.O.
Deposit date:2011-01-25
Release date:2012-01-11
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an Ebola Virus-Protective Antibody in Complex with its Mucin-Domain Linear Epitope.
J.Virol., 86, 2012
3CSY
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CRYSTAL STRUCTURE OF THE TRIMERIC PREFUSION EBOLA VIRUS GLYCOPROTEIN IN COMPLEX WITH A NEUTRALIZING ANTIBODY FROM A HUMAN SURVIVOR
Descriptor:Fab KZ52 heavy chain, Fab KZ52 light chain, Envelope glycoprotein GP1, ...
Authors:Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O.
Deposit date:2008-04-10
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Nature, 454, 2008
3INU
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CRYSTAL STRUCTURE OF AN UNBOUND KZ52 NEUTRALIZING ANTI-EBOLAVIRUS ANTIBODY.
Descriptor:KZ52 antibody fragment heavy chain, KZ52 antibody fragment light chain, SULFATE ION, ...
Authors:Lee, J.E., Fusco, M.L., Abelson, D.M., Hessell, A.J., Burton, D.R., Saphire, E.O.
Deposit date:2009-08-12
Release date:2009-10-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Acta Crystallogr.,Sect.D, 65, 2009
3KS4
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CRYSTAL STRUCTURE OF RESTON EBOLAVIRUS VP35 RNA BINDING DOMAIN
Descriptor:Polymerase cofactor VP35
Authors:Kimberlin, C.R., Bornholdt, Z.A., Li, S., Woods, V.L., Macrae, I.J., Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
3KS8
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CRYSTAL STRUCTURE OF RESTON EBOLAVIRUS VP35 RNA BINDING DOMAIN IN COMPLEX WITH 18BP DSRNA
Descriptor:5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3', 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3', Polymerase cofactor VP35
Authors:Kimberlin, C.R., Bornholdt, Z.A., Li, S., Woods, V.L., Macrae, I.J., Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
3Q7B
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EXONUCLEASE DOMAIN OF LASSA VIRUS NUCLEOPROTEIN
Descriptor:Nucleoprotein, ZINC ION, PHOSPHATE ION
Authors:Hastie, K.M., Kimberlin, C.R., Zandonatti, M.A., MacRae, I.J., Saphire, E.O.
Deposit date:2011-01-04
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q7C
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EXONUCLEASE DOMAIN OF LASSA VIRUS NUCLEOPROTEIN BOUND TO MANGANESE
Descriptor:Nucleoprotein, ZINC ION, MANGANESE (II) ION, ...
Authors:Hastie, K.M., Kimberlin, C.R., Zandonatti, M.A., MacRae, I.J., Saphire, E.O.
Deposit date:2011-01-04
Release date:2011-02-09
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T5N
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1.8A CRYSTAL STRUCTURE OF LASSA VIRUS NUCLEOPROTEIN IN COMPLEX WITH SSRNA
Descriptor:Nucleoprotein, RNA (5'-R(P*UP*AP*UP*CP*UP*C)-3'), NICKEL (II) ION
Authors:Hastie, K.M., Liu, T., King, L.B., Ngo, N., Zandonatti, M.A., Woods, V.L., de la Torre, J.C., Saphire, E.O.
Deposit date:2011-07-27
Release date:2012-01-11
Method:X-RAY DIFFRACTION (1.787 Å)
Cite:Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T5Q
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3A STRUCTURE OF LASSA VIRUS NUCLEOPROTEIN IN COMPLEX WITH SSRNA
Descriptor:Nucleoprotein, RNA (5'-R(P*UP*UP*AP*UP*CP*UP*CP*A)-3'), RNA (5'-R(P*UP*AP*UP*CP*UP*CP*A)-3'), ...
Authors:Hastie, K.M., Liu, T., King, L.B., Ngo, N., Zandonatti, M.A., Woods, V.L., de la Torre, J.C., Saphire, E.O.
Deposit date:2011-07-27
Release date:2012-01-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.
Proc.Natl.Acad.Sci.USA, 108, 2011
3TCQ
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CRYSTAL STRUCTURE OF MATRIX PROTEIN VP40 FROM EBOLA VIRUS SUDAN
Descriptor:Matrix protein VP40
Authors:Clifton, M.C., Edwards, T.E., Anderson, V., Atkins, K., Raymond, A., Saphire, E.O., Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-08-09
Release date:2012-10-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.
J Infect Dis, 212 Suppl 2, 2015
4FVU
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STRUCTURAL BASIS FOR THE DSRNA SPECIFICITY OF THE LASSA VIRUS NP EXONUCLEASE
Descriptor:Nucleoprotein, RNA (5'-R(*GP*GP*AP*GP*GP*GP*AP*G)-3'), RNA (5'-R(*CP*UP*CP*CP*CP*UP*CP*C)-3'), ...
Authors:Hastie, K.M., King, L.B., Zandonatti, M.A., Saphire, E.O.
Deposit date:2012-06-29
Release date:2012-09-19
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease.
Plos One, 7, 2012
4GH9
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CRYSTAL STRUCTURE OF MARBURG VIRUS VP35 RNA BINDING DOMAIN
Descriptor:Polymerase cofactor VP35, ACETATE ION
Authors:Bale, S., Jean-Philippe, J., Bornholdt, Z.A., Kimberlin, C.K., Halfmann, P., Zandonatti, M.A., Kunert, J., Kroon, G.J.A., Kawaoka, Y., MacRae, I.J., Wilson, I.A., Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-15
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012
4GHA
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CRYSTAL STRUCTURE OF MARBURG VIRUS VP35 RNA BINDING DOMAIN BOUND TO 12-BP DSRNA
Descriptor:Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3')
Authors:Bale, S., Jean-Philippe, J., Bornholdt, Z.A., Kimberlin, C.K., Halfmann, P., Zandonatti, M.A., Kunert, J., Kroon, G.J.A., Kawaoka, Y., MacRae, I.J., Wilson, I.A., Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-22
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012
4LD8
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CRYSTAL STRUCTURE OF DIMERIC SUDAN VIRUS VP40
Descriptor:Matrix protein VP40
Authors:Bornholdt, Z.A., Ableson, D.M., Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LDB
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CRYSTAL STRUCTURE OF EBOLA VIRUS VP40 DIMER
Descriptor:Matrix protein VP40
Authors:Bornholdt, Z.A., Ableson, D.M., Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LDD
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CRYSTAL STRUCTURE OF EBOLA VIRUS VP40 HEXAMER
Descriptor:Matrix protein VP40
Authors:Bornholdt, Z.A., Ableson, D.M., Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (3.498 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LDI
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LOW RESOLUTION STRUCTURE OF EBOLA VIRUS M241R MUTANT
Descriptor:Matrix protein VP40
Authors:Bornholdt, Z.A., Ableson, D.M., Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (4.15 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LDM
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CRYSTAL STRUCTURE OF AN RNA-FREE VP40 OCTAMERIC RING
Descriptor:Matrix protein VP40
Authors:Bornholdt, Z.A., Ableson, D.M., Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LG2
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CRYSTAL STRUCTURE OF RESTON EBOLA VIRUS VP35 RNA BINDING DOMAIN BOUND TO 12-BP DSRNA
Descriptor:Polymerase cofactor, dsRNA
Authors:Bale, S., Julien, J.-P., Bornholdt, Z.A., Krois, A.S., Wilson, I.A., Saphire, E.O.
Deposit date:2013-06-27
Release date:2013-07-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism.
J.Virol., 87, 2013
4N5B
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CRYSTAL STRUCTURE OF THE NIPAH VIRUS PHOSPHOPROTEIN TETRAMERIZATION DOMAIN
Descriptor:Phosphoprotein, IMIDAZOLE
Authors:Bruhn, J.F., Barnett, K., Bibby, J., Thomas, J., Keegan, R., Rigden, D., Bornholdt, Z.A., Saphire, E.O.
Deposit date:2013-10-09
Release date:2013-11-27
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the nipah virus phosphoprotein tetramerization domain.
J.Virol., 88, 2014
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