4F92
| Brr2 Helicase Region S1087L | Descriptor: | SULFANILAMIDE, U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | Deposit date: | 2012-05-18 | Release date: | 2012-10-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.662 Å) | Cite: | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F91
| Brr2 Helicase Region | Descriptor: | U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | Deposit date: | 2012-05-18 | Release date: | 2012-10-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.697 Å) | Cite: | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F93
| Brr2 Helicase Region S1087L, Mg-ATP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | Deposit date: | 2012-05-18 | Release date: | 2012-10-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc.Natl.Acad.Sci.USA, 109, 2012
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6S8Q
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 | Descriptor: | Pre-mRNA-processing-splicing factor 8, SULFATE ION, U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Santos, K.F, Vester, K, Wahl, M.C. | Deposit date: | 2019-07-10 | Release date: | 2020-01-22 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.391 Å) | Cite: | The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
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7BDK
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ... | Authors: | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | Deposit date: | 2020-12-21 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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7BDJ
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS | Descriptor: | MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | Authors: | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | Deposit date: | 2020-12-21 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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7BDL
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ADP | Descriptor: | MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | Authors: | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | Deposit date: | 2020-12-21 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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7BDI
| Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ATPgammaS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pre-mRNA-processing-splicing factor 8, ... | Authors: | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | Deposit date: | 2020-12-21 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
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5DCA
| Crystal structure of yeast full length Brr2 in complex with Prp8 Jab1 domain | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | Authors: | Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | Deposit date: | 2015-08-23 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes Dev., 29, 2015
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4RVQ
| PWI-like domain of Chaetomium thermophilum Brr2 | Descriptor: | 1,2-ETHANEDIOL, Pre-mRNA splicing helicase-like protein, SULFATE ION | Authors: | Absmeier, E, Rosenberger, L, Santos, K.F, Becke, C, Wahl, M.C. | Deposit date: | 2014-11-27 | Release date: | 2015-04-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.135 Å) | Cite: | A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein. Acta Crystallogr.,Sect.D, 71, 2015
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5M59
| Crystal structure of Chaetomium thermophilum Brr2 helicase core in complex with Prp8 Jab1 domain | Descriptor: | ACETATE ION, Pre-mRNA splicing helicase-like protein, Putative pre-mRNA splicing factor | Authors: | Absmeier, E, Becke, C, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | Deposit date: | 2016-10-20 | Release date: | 2016-12-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle, 16, 2017
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5M52
| Crystal structure of yeast Brr2 full-lenght in complex with Prp8 Jab1 domain | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | Authors: | Wollenhaupt, J, Absmeier, E, Becke, C, Santos, K.F, Wahl, M.C. | Deposit date: | 2016-10-20 | Release date: | 2016-12-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle, 16, 2017
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5M5P
| S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of S. cerevisiae Prp8 | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | Authors: | Becke, C, Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | Deposit date: | 2016-10-22 | Release date: | 2016-12-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2. Cell Cycle, 16, 2017
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6QWS
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6QV3
| Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum bound to ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | Authors: | Absmeier, E, Santos, K.F, Wahl, M.C. | Deposit date: | 2019-03-01 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase. Structure, 28, 2020
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6QV4
| Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum bound to ATP-gamma-S | Descriptor: | ACETATE ION, MANGANESE (II) ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Absmeier, E, Santos, K.F, Wahl, M.C. | Deposit date: | 2019-03-01 | Release date: | 2020-01-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase. Structure, 28, 2020
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3SBT
| Crystal structure of a Aar2-Prp8 complex | Descriptor: | A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8, S-1,2-PROPANEDIOL, ... | Authors: | Weber, G, Santos, K.F, Holton, N, Wahl, M.C. | Deposit date: | 2011-06-06 | Release date: | 2011-07-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev., 25, 2011
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3SBS
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4ILI
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4ILJ
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4ILH
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4ILG
| Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | Authors: | Weber, G, Heroven, A.C, Santos, K.F, Wahl, M.C. | Deposit date: | 2012-12-31 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes Dev., 27, 2013
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4KIT
| Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ... | Authors: | Wahl, M.C, Wandersleben, T, Santos, K.F. | Deposit date: | 2013-05-02 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.598 Å) | Cite: | Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science, 341, 2013
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6S9I
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6S8O
| Human Brr2 Helicase Region M641C/A1582C | Descriptor: | U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Vester, K, Santos, K.F, Wahl, M.C. | Deposit date: | 2019-07-10 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.172 Å) | Cite: | The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
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