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4F92
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BU of 4f92 by Molmil
Brr2 Helicase Region S1087L
Descriptor: SULFANILAMIDE, U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C.
Deposit date:2012-05-18
Release date:2012-10-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.662 Å)
Cite:Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F91
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BU of 4f91 by Molmil
Brr2 Helicase Region
Descriptor: U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C.
Deposit date:2012-05-18
Release date:2012-10-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F93
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BU of 4f93 by Molmil
Brr2 Helicase Region S1087L, Mg-ATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C.
Deposit date:2012-05-18
Release date:2012-10-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Proc.Natl.Acad.Sci.USA, 109, 2012
6S8Q
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BU of 6s8q by Molmil
Human Brr2 Helicase Region in complex with C-tail deleted Jab1
Descriptor: Pre-mRNA-processing-splicing factor 8, SULFATE ION, U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Santos, K.F, Vester, K, Wahl, M.C.
Deposit date:2019-07-10
Release date:2020-01-22
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.391 Å)
Cite:The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit.
J.Biol.Chem., 295, 2020
7BDK
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BU of 7bdk by Molmil
Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ...
Authors:Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C.
Deposit date:2020-12-21
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
7BDJ
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BU of 7bdj by Molmil
Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS
Descriptor: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ...
Authors:Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C.
Deposit date:2020-12-21
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
7BDL
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BU of 7bdl by Molmil
Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ADP
Descriptor: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ...
Authors:Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C.
Deposit date:2020-12-21
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
7BDI
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BU of 7bdi by Molmil
Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ATPgammaS
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pre-mRNA-processing-splicing factor 8, ...
Authors:Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C.
Deposit date:2020-12-21
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
5DCA
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BU of 5dca by Molmil
Crystal structure of yeast full length Brr2 in complex with Prp8 Jab1 domain
Descriptor: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2
Authors:Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C.
Deposit date:2015-08-23
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.
Genes Dev., 29, 2015
4RVQ
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BU of 4rvq by Molmil
PWI-like domain of Chaetomium thermophilum Brr2
Descriptor: 1,2-ETHANEDIOL, Pre-mRNA splicing helicase-like protein, SULFATE ION
Authors:Absmeier, E, Rosenberger, L, Santos, K.F, Becke, C, Wahl, M.C.
Deposit date:2014-11-27
Release date:2015-04-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.135 Å)
Cite:A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.
Acta Crystallogr.,Sect.D, 71, 2015
5M59
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BU of 5m59 by Molmil
Crystal structure of Chaetomium thermophilum Brr2 helicase core in complex with Prp8 Jab1 domain
Descriptor: ACETATE ION, Pre-mRNA splicing helicase-like protein, Putative pre-mRNA splicing factor
Authors:Absmeier, E, Becke, C, Wollenhaupt, J, Santos, K.F, Wahl, M.C.
Deposit date:2016-10-20
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Cell Cycle, 16, 2017
5M52
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BU of 5m52 by Molmil
Crystal structure of yeast Brr2 full-lenght in complex with Prp8 Jab1 domain
Descriptor: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2
Authors:Wollenhaupt, J, Absmeier, E, Becke, C, Santos, K.F, Wahl, M.C.
Deposit date:2016-10-20
Release date:2016-12-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Cell Cycle, 16, 2017
5M5P
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BU of 5m5p by Molmil
S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of S. cerevisiae Prp8
Descriptor: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2
Authors:Becke, C, Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C.
Deposit date:2016-10-22
Release date:2016-12-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Cell Cycle, 16, 2017
6QWS
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BU of 6qws by Molmil
Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum in the apo state
Descriptor: Pre-mRNA splicing helicase-like protein, SULFATE ION
Authors:Absmeier, E, Santos, K.F, Wahl, M.C.
Deposit date:2019-03-06
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase.
Structure, 28, 2020
6QV3
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BU of 6qv3 by Molmil
Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ...
Authors:Absmeier, E, Santos, K.F, Wahl, M.C.
Deposit date:2019-03-01
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase.
Structure, 28, 2020
6QV4
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BU of 6qv4 by Molmil
Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum bound to ATP-gamma-S
Descriptor: ACETATE ION, MANGANESE (II) ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Absmeier, E, Santos, K.F, Wahl, M.C.
Deposit date:2019-03-01
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase.
Structure, 28, 2020
3SBT
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BU of 3sbt by Molmil
Crystal structure of a Aar2-Prp8 complex
Descriptor: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8, S-1,2-PROPANEDIOL, ...
Authors:Weber, G, Santos, K.F, Holton, N, Wahl, M.C.
Deposit date:2011-06-06
Release date:2011-07-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Mechanism for Aar2p function as a U5 snRNP assembly factor.
Genes Dev., 25, 2011
3SBS
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BU of 3sbs by Molmil
Crystal structure of Aar2 protein
Descriptor: A1 cistron-splicing factor AAR2
Authors:Weber, G, Santos, K.F, Holton, N, Wahl, M.C.
Deposit date:2011-06-06
Release date:2012-04-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism for Aar2p function as a U5 snRNP assembly factor.
Genes Dev., 25, 2011
4ILI
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BU of 4ili by Molmil
Crystal structure of an Aar2p S253E phosphomimetic mutant protein
Descriptor: A1 cistron-splicing factor AAR2
Authors:Weber, G, Heroven, C, Santos, K.F, Wahl, M.C.
Deposit date:2012-12-31
Release date:2013-03-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2046 Å)
Cite:Structural basis for dual roles of Aar2p in U5 snRNP assembly.
Genes Dev., 27, 2013
4ILJ
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BU of 4ilj by Molmil
Crystal structure of an Prp8p RNaseH W1911A mutant protein
Descriptor: Pre-mRNA-splicing factor 8
Authors:Weber, G, Heroven, C, Santos, K.F, Wahl, M.C.
Deposit date:2012-12-31
Release date:2013-03-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.0001 Å)
Cite:Structural basis for dual roles of Aar2p in U5 snRNP assembly.
Genes Dev., 27, 2013
4ILH
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BU of 4ilh by Molmil
Crystal structure of an Aar2p C-terminal deletion mutant in conplex with Prp8p RNaseH
Descriptor: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8
Authors:Weber, G, Heroven, A.C, Santos, K.F, Wahl, M.C.
Deposit date:2012-12-31
Release date:2013-03-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the Aar2p-mediated regulation of Prp8p interactions with Brr2p and U4/U6 di-snRNA
To be Published
4ILG
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BU of 4ilg by Molmil
Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8
Authors:Weber, G, Heroven, A.C, Santos, K.F, Wahl, M.C.
Deposit date:2012-12-31
Release date:2013-03-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for dual roles of Aar2p in U5 snRNP assembly.
Genes Dev., 27, 2013
4KIT
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BU of 4kit by Molmil
Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ...
Authors:Wahl, M.C, Wandersleben, T, Santos, K.F.
Deposit date:2013-05-02
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.
Science, 341, 2013
6S9I
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BU of 6s9i by Molmil
Human Brr2 Helicase Region D534C/N1866C in complex with C-tail deleted Jab1
Descriptor: Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Vester, K, Santos, K.F, Wahl, M.C.
Deposit date:2019-07-13
Release date:2020-01-22
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit.
J.Biol.Chem., 295, 2020
6S8O
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BU of 6s8o by Molmil
Human Brr2 Helicase Region M641C/A1582C
Descriptor: U5 small nuclear ribonucleoprotein 200 kDa helicase
Authors:Vester, K, Santos, K.F, Wahl, M.C.
Deposit date:2019-07-10
Release date:2020-01-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.172 Å)
Cite:The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit.
J.Biol.Chem., 295, 2020

 

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