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5MMN
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E. COLI DNA GYRASE B 24 KDA ATPASE DOMAIN IN COMPLEX WITH 1-ETHYL-3-[8-METHYL-5-(2-METHYL-PYRIDIN-4-YL)-ISOQUINOLIN-3-YL]-UREA
Descriptor:DNA gyrase subunit B, 1-ethyl-3-[8-methyl-5-(2-methylpyridin-4-yl)isoquinolin-3-yl]urea
Authors:Panchaud, P., Bruyere, T., Blumstein, A.-C., Bur, D., Chambovey, A., Ertel, E.A., Gude, M., Hubschwerlen, C., Jacob, L., Kimmerlin, T., Pfeifer, T., Prade, L., Seiler, P., Ritz, D., Rueedi, G.
Deposit date:2016-12-12
Release date:2017-04-26
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
J. Med. Chem., 60, 2017
5MMO
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E. COLI DNA GYRASE B 24 KDA ATPASE DOMAIN IN COMPLEX WITH [3-(3-ETHYL-UREIDO)-5-(PYRIDIN-4-YL)-ISOQUINOLIN-8-YL-METHYL]-CARBAMIC ACID PROP-2-YNYL ESTER
Descriptor:DNA gyrase subunit B, prop-2-ynyl ~{N}-[[3-(ethylcarbamoylamino)-5-pyridin-4-yl-isoquinolin-8-yl]methyl]carbamate, PHOSPHATE ION
Authors:Panchaud, P., Bruyere, T., Blumstein, A.-C., Bur, D., Chambovey, A., Ertel, E.A., Gude, M., Hubschwerlen, C., Jacob, L., Kimmerlin, T., Pfeifer, T., Prade, L., Seiler, P., Ritz, D., Rueedi, G.
Deposit date:2016-12-12
Release date:2017-04-26
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
J. Med. Chem., 60, 2017
5MMP
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E. COLI DNA GYRASE B 24 KDA ATPASE DOMAIN IN COMPLEX WITH 1-ETHYL-3-[5-PYRIDIN-4-YL-8-(PYRIDIN-3-YLAMINO)-ISOQUINOLIN-3-YL]-UREA
Descriptor:DNA gyrase subunit B, 1-ethyl-3-[5-pyridin-4-yl-8-(pyridin-3-ylamino)isoquinolin-3-yl]urea
Authors:Panchaud, P., Bruyere, T., Blumstein, A.-C., Bur, D., Chambovey, A., Ertel, E.A., Gude, M., Hubschwerlen, C., Jacob, L., Kimmerlin, T., Pfeifer, T., Prade, L., Seiler, P., Ritz, D., Rueedi, G.
Deposit date:2016-12-12
Release date:2017-04-26
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
J. Med. Chem., 60, 2017
6QUL
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STRUCTURE OF A BACTERIAL 50S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE NOVEL QUINOXOLIDINONE ANTIBIOTIC CADAZOLID
Descriptor:P-site fMet-tRNA(fMet), 23S rRNA, 5S rRNA, ...
Authors:Scaiola, A., Leibundgut, M., Boehringer, D., Ritz, D.
Deposit date:2019-02-27
Release date:2019-04-10
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic.
Sci Rep, 9, 2019