1E4E
| D-alanyl-D-lacate ligase | Descriptor: | 1(S)-AMINOETHYL-(2-CARBOXYPROPYL)PHOSPHORYL-PHOSPHINIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Roper, D.I. | Deposit date: | 2000-07-03 | Release date: | 2001-06-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA). Proc. Natl. Acad. Sci. U.S.A., 97, 2000
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1GQZ
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7ZG8
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6FTB
| Staphylococcus aureus monofunctional glycosyltransferase in complex with moenomycin | Descriptor: | (2R)-2,3-dihydroxypropyl dodecanoate, 1,2-ETHANEDIOL, MOENOMYCIN, ... | Authors: | Punekar, A.S, Dowson, C.J, Roper, D.I. | Deposit date: | 2018-02-20 | Release date: | 2018-06-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization. Cell Surf, 2, 2018
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3FVE
| Crystal structure of diaminopimelate epimerase Mycobacterium tuberculosis DapF | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Diaminopimelate epimerase, GLYCEROL | Authors: | Usha, V, Dover, L.G, Roper, D.I, Futterer, K, Besra, G.S. | Deposit date: | 2009-01-15 | Release date: | 2009-01-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis Acta Crystallogr.,Sect.D, 65, 2009
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5UG1
| Structure of Streptococcus pneumoniae peptidoglycan O-acetyltransferase A (OatA) C-terminal catalytic domain with methylsulfonyl adduct | Descriptor: | Acyltransferase, SODIUM ION, methanesulfonic acid | Authors: | Sychantha, D, Jones, C, Little, D.J, Moynihan, P.J, Robinson, H, Galley, N.F, Roper, D.I, Dowson, C.G, Howell, P.L, Clarke, A.J. | Deposit date: | 2017-01-06 | Release date: | 2017-10-25 | Last modified: | 2017-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). PLoS Pathog., 13, 2017
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5UFY
| Structure of Streptococcus pneumoniae peptidoglycan O-acetyltransferase A (OatA) C-terminal catalytic domain | Descriptor: | Acyltransferase, SODIUM ION | Authors: | Sychantha, D, Jones, C, Little, D.J, Moynihan, P.J, Robinson, H, Galley, N.F, Roper, D.I, Dowson, C.G, Howell, P.L, Clarke, A.J. | Deposit date: | 2017-01-06 | Release date: | 2017-10-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). PLoS Pathog., 13, 2017
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7A2D
| Structure-function analyses of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation to the cell division site | Descriptor: | Uncharacterized protein YraP | Authors: | Bryant, J.A, Morris, F.C, Knowles, T.J, Maderbocus, R, Heinz, E, Boelter, G, Alodaini, D, Colyer, A, Wotherspoon, P.J, Staunton, K.A, Jeeves, M, Browning, D.F, Sevastsyanovich, Y.R, Wells, T.J, Rossiter, A.E, Bavro, V.N, Sridhar, P, Ward, D.G, Chong, Z.S, Goodall, E.C.A, Icke, C, Teo, A, Chng, S.S, Roper, D.I, Lithgow, T, Cunningham, A.F, Banzhaf, M, Overduin, M, Henderson, I.R. | Deposit date: | 2020-08-17 | Release date: | 2020-12-30 | Last modified: | 2021-02-10 | Method: | SOLUTION NMR | Cite: | Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation. Elife, 9, 2020
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6R1N
| Crystal structure of S. aureus seryl-tRNA synthetase complexed to seryl sulfamoyl adenosine | Descriptor: | 1,2-ETHANEDIOL, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Salimraj, R, Cain, R, Roper, D.I. | Deposit date: | 2019-03-14 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J.Med.Chem., 62, 2019
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6R1O
| Crystal structure of E. coli seryl-tRNA synthetase complexed to a seryl sulfamoyl adenosine derivative | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Salimraj, R, Cain, R, Roper, D.I. | Deposit date: | 2019-03-14 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J.Med.Chem., 62, 2019
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6R1M
| Crystal structure of E. coli seryl-tRNA synthetase complexed to seryl sulfamoyl adenosine | Descriptor: | 1,2-ETHANEDIOL, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, PHOSPHATE ION, ... | Authors: | Salimraj, R, Cain, R, Roper, D.I. | Deposit date: | 2019-03-14 | Release date: | 2020-01-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J.Med.Chem., 62, 2019
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1OTF
| 4-OXALOCROTONATE TAUTOMERASE-TRICLINIC CRYSTAL FORM | Descriptor: | 4-OXALOCROTONATE TAUTOMERASE | Authors: | Subramanya, H.S, Roper, D.I, Dauter, Z, Dodson, E.J, Davies, G.J, Wilson, K.S, Wigley, D.B. | Deposit date: | 1995-11-09 | Release date: | 1996-04-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases. Biochemistry, 35, 1996
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1OTG
| 5-CARBOXYMETHYL-2-HYDROXYMUCONATE ISOMERASE | Descriptor: | 5-CARBOXYMETHYL-2-HYDROXYMUCONATE ISOMERASE, SULFATE ION | Authors: | Subramanya, H.S, Roper, D.I, Dauter, Z, Dodson, E.J, Davies, G.J, Wilson, K.S, Wigley, D.B. | Deposit date: | 1995-11-09 | Release date: | 1996-04-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases. Biochemistry, 35, 1996
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1GTT
| CRYSTAL STRUCTURE OF HPCE | Descriptor: | 4-HYDROXYPHENYLACETATE DEGRADATION BIFUNCTIONAL ISOMERASE/DECARBOXYLASE, CALCIUM ION | Authors: | Tame, J.R.H, Namba, K, Dodson, E.J, Roper, D.I. | Deposit date: | 2002-01-18 | Release date: | 2002-03-08 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Crystal Structure of Hpce, a Bifunctional Decarboxylase/Isomerase with a Multifunctional Fold. Biochemistry, 41, 2002
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2EB4
| Crystal structure of apo-HpcG | Descriptor: | 2-oxo-hept-3-ene-1,7-dioate hydratase, SODIUM ION, THIOCYANATE ION | Authors: | Izumi, A, Rea, D, Adachi, T, Unzai, S, Park, S.Y, Roper, D.I, Tame, J.R.H. | Deposit date: | 2007-02-07 | Release date: | 2007-07-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli J.Mol.Biol., 370, 2007
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2EB5
| Crystal structure of HpcG complexed with oxalate | Descriptor: | 2-oxo-hept-3-ene-1,7-dioate hydratase, MAGNESIUM ION, OXALATE ION, ... | Authors: | Izumi, A, Rea, D, Adachi, T, Unzai, S, Park, S.Y, Roper, D.I, Tame, J.R.H. | Deposit date: | 2007-02-07 | Release date: | 2007-07-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli J.Mol.Biol., 370, 2007
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2EB6
| Crystal structure of HpcG complexed with Mg ion | Descriptor: | 2-oxo-hept-3-ene-1,7-dioate hydratase, MAGNESIUM ION | Authors: | Izumi, A, Rea, D, Adachi, T, Unzai, S, Park, S.Y, Roper, D.I, Tame, J.R.H. | Deposit date: | 2007-02-07 | Release date: | 2007-07-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli J.Mol.Biol., 370, 2007
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2EX2
| Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli | Descriptor: | GLYCEROL, Penicillin-binding protein 4 | Authors: | Kishida, H, Unzai, S, Roper, D.I, Lloyd, A, Park, S.-Y, Tame, J.R.H. | Deposit date: | 2005-11-07 | Release date: | 2006-06-13 | Last modified: | 2016-10-19 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics Biochemistry, 45, 2006
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3A3J
| Crystal structures of penicillin binding protein 5 from Haemophilus influenzae | Descriptor: | PBP5, SULFATE ION | Authors: | Kawai, F, Roper, D.I, Park, S.-Y, Tame, J.R.H. | Deposit date: | 2009-06-12 | Release date: | 2009-12-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae J.Mol.Biol., 396, 2010
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3A3D
| Crystal structure of penicillin binding protein 4 (dacB) from Haemophilus influenzae | Descriptor: | GLYCEROL, Penicillin-binding protein 4 | Authors: | Kawai, F, Roper, D.I, Park, S.-Y, Tame, J.R.H. | Deposit date: | 2009-06-12 | Release date: | 2009-12-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae J.Mol.Biol., 396, 2010
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3A3E
| Crystal structure of penicillin binding protein 4 (dacB) from Haemophilus influenzae, complexed with novel beta-lactam (CMV) | Descriptor: | (2R,4S)-2-[(1R)-1-({(2R)-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)amino]-2-phenylacetyl}amino)-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Penicillin-binding protein 4 | Authors: | Kawai, F, Roper, D.I, Park, S.-Y, Tame, J.R.H. | Deposit date: | 2009-06-12 | Release date: | 2009-12-22 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae J.Mol.Biol., 396, 2010
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1S4D
| Crystal Structure Analysis of the S-adenosyl-L-methionine dependent uroporphyrinogen-III C-methyltransferase SUMT | Descriptor: | GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, Uroporphyrin-III C-methyltransferase | Authors: | Vevodova, J, Graham, R.M, Raux, E, Schubert, H.L, Roper, D.I, Brindley, A.A, Scott, A.I, Roessner, C.A, Stamford, N.P.J, Stroupe, M.E, Getzoff, E.D, Warren, M.J, Wilson, K.S. | Deposit date: | 2004-01-16 | Release date: | 2004-11-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure/Function Studies on a S-Adenosyl-l-methionine-dependent Uroporphyrinogen III C Methyltransferase (SUMT), a Key Regulatory Enzyme of Tetrapyrrole Biosynthesis J.Mol.Biol., 344, 2004
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1GZI
| CRYSTAL STRUCTURE OF TYPE III ANTIFREEZE PROTEIN FROM OCEAN POUT, AT 1.8 ANGSTROM RESOLUTION | Descriptor: | HPLC-12 TYPE III ANTIFREEZE PROTEIN | Authors: | Antson, A.A, Lewis, S, Roper, D.I, Smith, D.J, Hubbard, R.E. | Deposit date: | 1996-10-25 | Release date: | 1997-09-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Structure of Type III Antifreeze Protein from Ocean Pout To be Published
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1HG7
| High resolution structure of HPLC-12 type III antifreeze protein from Ocean Pout Macrozoarces americanus | Descriptor: | HPLC-12 TYPE III ANTIFREEZE PROTEIN, SULFATE ION | Authors: | Antson, A.A, Smith, D.J, Roper, D.I, Lewis, S, Caves, L.S.D, Verma, C.S, Buckley, S.L, Lillford, P.J, Hubbard, R.E. | Deposit date: | 2000-12-13 | Release date: | 2001-01-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Understanding the Mechanism of Ice Binding by Type III Antifreeze Protein J.Mol.Biol., 305, 2001
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1I7O
| CRYSTAL STRUCTURE OF HPCE | Descriptor: | 4-HYDROXYPHENYLACETATE DEGRADATION BIFUNCTIONAL ISOMERASE/DECARBOXYLASE, CALCIUM ION | Authors: | Tame, J.R.H, Namba, K, Dodson, E.J, Roper, D.I. | Deposit date: | 2001-03-10 | Release date: | 2001-03-28 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The crystal structure of HpcE, a multi-functional enzyme fold To be Published
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