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1L8L
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MOLECULAR BASIS FOR THE LOCAL CONFOMATIONAL REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE
Descriptor:L-3-phosphoserine phosphatase, D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID
Authors:Kim, H.Y., Heo, Y.S., Kim, J.H., Park, M.H., Moon, J., Park, S.Y., Lee, T.G., Jeon, Y.H., Ro, S., Hwang, K.Y.
Deposit date:2002-03-21
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.
J.Biol.Chem., 277, 2002
1L8O
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MOLECULAR BASIS FOR THE LOCAL CONFORMATIONAL REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE
Descriptor:L-3-phosphoserine phosphatase, PHOSPHATE ION, SERINE
Authors:Kim, H.Y., Heo, Y.S., Kim, J.H., Park, M.H., Moon, J., Park, S.Y., Lee, T.G., Jeon, Y.H., Ro, S., Hwang, K.Y.
Deposit date:2002-03-21
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase
J.Biol.Chem., 277, 2002
1UDT
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH SILDENAFIL(VIAGRA)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-05-06
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UDU
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH TADALAFIL(CIALIS)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-05-06
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UHO
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH VARDENAFIL(LEVITRA)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-07-09
Release date:2004-07-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UKH
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STRUCTURAL BASIS FOR THE SELECTIVE INHIBITION OF JNK1 BY THE SCAFFOLDING PROTEIN JIP1 AND SP600125
Descriptor:Mitogen-activated protein kinase 8 isoform 4, 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1
Authors:Heo, Y.-S., Kim, Y.K., Sung, B.-J., Lee, H.S., Lee, J.I., Seo, C.I., Park, S.-Y., Kim, J.H., Hyun, Y.-L., Jeon, Y.H., Ro, S., Lee, T.G., Cho, J.M., Hwang, K.Y., Yang, C.-H.
Deposit date:2003-08-23
Release date:2004-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Embo J., 23, 2004
1UKI
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STRUCTURAL BASIS FOR THE SELECTIVE INHIBITION OF JNK1 BY THE SCAFFOLDING PROTEIN JIP1 AND SP600125
Descriptor:mitogen-activated protein kinase 8 isoform 4, 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1, 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE
Authors:Heo, Y.-S., Kim, Y.K., Sung, B.-J., Lee, H.S., Lee, J.I., Seo, C.I., Park, S.-Y., Kim, J.H., Hyun, Y.-L., Jeon, Y.H., Ro, S., Lee, T.G., Cho, J.M., Hwang, K.Y., Yang, C.-H.
Deposit date:2003-08-23
Release date:2004-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Embo J., 23, 2004
2O5K
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CRYSTAL STRUCTURE OF GSK3BETA IN COMPLEX WITH A BENZOIMIDAZOL INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, 2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID [2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-AMIDE
Authors:Shin, D., Lee, S.C., Heo, Y.S., Cho, Y.S., Kim, Y.E., Hyun, Y.L., Cho, J.M., Lee, Y.S., Ro, S.
Deposit date:2006-12-06
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta
Bioorg.Med.Chem.Lett., 17, 2007
5W5J
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IDENTIFICATION OF POTENT AND SELECTIVE RIPK2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
Descriptor:Receptor-interacting serine/threonine-protein kinase 2, N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide, SULFATE ION
Authors:Kreusch, A., Spraggon, G.
Deposit date:2017-06-15
Release date:2017-10-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
ACS Med Chem Lett, 8, 2017
5W5O
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IDENTIFICATION OF POTENT AND SELECTIVE RIPK2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES.
Descriptor:Receptor-interacting serine/threonine-protein kinase 2, 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine
Authors:Kreusch, A., Spraggon, G.
Deposit date:2017-06-15
Release date:2017-10-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
ACS Med Chem Lett, 8, 2017
1V3A
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STRUCTURE OF HUMAN PRL-3, THE PHOSPHATASE ASSOCIATED WITH CANCER METASTASIS
Descriptor:protein tyrosine phosphatase type IVA
Authors:Jeon, Y.H., Cheong, C.
Deposit date:2003-10-30
Release date:2004-10-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of human PRL-3, the phosphatase associated with cancer metastasis
Febs Lett., 565, 2004
2F0Y
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CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND HYDANTOIN DERIVATIVE
Descriptor:Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Kim, K.H., Lee, J., Kim, J.
Deposit date:2005-11-14
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:hydantoin derivatives as Non-pepridic inhibitors of Ras Farnesyl transferase
To be published
2HJW
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CRYSTAL STRUCTURE OF THE BC DOMAIN OF ACC2
Descriptor:Acetyl-CoA carboxylase 2
Authors:Cho, Y.S., Lee, J.I., Shin, D., Kim, H.T., Lee, T.G., Heo, Y.S.
Deposit date:2006-07-02
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.
Proteins, 70, 2008
3PJD
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STRUCTURE OF ENR G93A MUTANT-NAD+-TRICLOSAN COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Kim, H.T., Shin, D.G., Chang, H.J.
Deposit date:2010-11-10
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of triclosan resistance
J.Struct.Biol., 174, 2011
3PJE
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STRUCTURE OF ENR G93S MUTANT-NAD+-TRICLOSAN COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Kim, H.T., Shin, D.G., Chang, H.J.
Deposit date:2010-11-10
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of triclosan resistance
J.Struct.Biol., 174, 2011
3PJF
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STRUCTURE OF ENR G93V MUTANT-NAD+-TRICLOSAN COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Kim, H.T., Shin, D.G., Chang, H.J.
Deposit date:2010-11-10
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of triclosan resistance
J.Struct.Biol., 174, 2011