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5L3A
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FRAGMENT-BASED DISCOVERY OF 6-ARYLINDAZOLE JAK INHIBITORS
Descriptor:Tyrosine-protein kinase JAK2, ~{N}-(1~{H}-indazol-4-yl)methanesulfonamide
Authors:Soerensen, M.D., Dack, K.N., Greve, D.R., Ritzen, A.
Deposit date:2016-04-06
Release date:2016-04-27
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors.
Acs Med.Chem.Lett., 7, 2016
2Y0J
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TRIAZOLOQUINAZOLINES AS A NOVEL CLASS OF PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS, PART 2, LEAD-OPTIMISATION.
Descriptor:CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, 5-(1H-BENZIMIDAZOL-2-YLMETHYLSULFANYL)-2-METHYL-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE, ...
Authors:Kehler, J., Ritzen, A., Langgard, M., Petersen, S.L., Christoffersen, C.T., Nielsen, J., Kilburn, J.P.
Deposit date:2010-12-03
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Triazoloquinazolines as a Novel Class of Phosphodiesterase 10A (Pde10A) Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011