Author results

1AM4
  • Download 1am4
  • View 1am4
Molmil generated image of 1am4
COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS)
Descriptor:P50-RHOGAP, CDC42HS, MAGNESIUM ION, ...
Authors:Rittinger, K., Walker, P., Gamblin, S.J., Smerdon, S.J.
Deposit date:1997-06-22
Release date:1998-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Nature, 388, 1997
1QJA
  • Download 1qja
  • View 1qja
Molmil generated image of 1qja
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
Descriptor:14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
Authors:Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1QJB
  • Download 1qjb
  • View 1qjb
Molmil generated image of 1qjb
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
Descriptor:14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
Authors:Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1TX4
  • Download 1tx4
  • View 1tx4
Molmil generated image of 1tx4
RHO/RHOGAP/GDP(DOT)ALF4 COMPLEX
Descriptor:P50-RHOGAP, TRANSFORMING PROTEIN RHOA, MAGNESIUM ION, ...
Authors:Rittinger, K., Walker, P.A., Smerdon, S.J., Gamblin, S.J.
Deposit date:1997-07-29
Release date:1998-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue.
Nature, 389, 1997
5FER
  • Download 5fer
  • View 5fer
Molmil generated image of 5fer
COMPLEX OF TRIM25 RING WITH UBCH5-UB
Descriptor:E3 ubiquitin/ISG15 ligase TRIM25, Ubiquitin-conjugating enzyme E2 D1, Ubiquitin-40S ribosomal protein S27a, ...
Authors:Rittinger, K., Koliopoulos, M.G., Esposito, D.
Deposit date:2015-12-17
Release date:2016-05-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
Embo J., 35, 2016
5FEY
  • Download 5fey
  • View 5fey
Molmil generated image of 5fey
TRIM32 RING
Descriptor:E3 ubiquitin-protein ligase TRIM32, ZINC ION
Authors:Rittinger, K., Esposito, D., Koliopoulos, M.G.
Deposit date:2015-12-17
Release date:2016-05-18
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
Embo J., 35, 2016
1E96
  • Download 1e96
  • View 1e96
Molmil generated image of 1e96
STRUCTURE OF THE RAC/P67PHOX COMPLEX
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, NEUTROPHIL CYTOSOL FACTOR 2 (NCF-2) TPR DOMAIN, RESIDUES 1-203, ...
Authors:Lapouge, K., Smith, S.J.M., Walker, P.A., Gamblin, S.J., Smerdon, S.J., Rittinger, K.
Deposit date:2000-10-10
Release date:2000-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Tpr Domain of P67Phox in Complex with Rac.GTP
Mol.Cell, 6, 2000
1NG2
  • Download 1ng2
  • View 1ng2
Molmil generated image of 1ng2
STRUCTURE OF AUTOINHIBITED P47PHOX
Descriptor:Neutrophil cytosolic factor 1
Authors:Groemping, Y., Lapouge, K., Smerdon, S.J., Rittinger, K.
Deposit date:2002-12-16
Release date:2003-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of phosphorylation-induced activation of the NADPH oxidase
Cell(Cambridge,Mass.), 113, 2003
1OV3
  • Download 1ov3
  • View 1ov3
Molmil generated image of 1ov3
STRUCTURE OF THE P22PHOX-P47PHOX COMPLEX
Descriptor:Neutrophil cytosol factor 1, Flavocytochrome b558 alpha polypeptide
Authors:Groemping, Y., Lapouge, K., Smerdon, S.J., Rittinger, K.
Deposit date:2003-03-25
Release date:2003-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis of phosphorylation-induced activation of the NADPH oxidase
Cell(Cambridge,Mass.), 113, 2003
6GZY
  • Download 6gzy
  • View 6gzy
Molmil generated image of 6gzy
HOIP-FRAGMENT5 COMPLEX
Descriptor:E3 ubiquitin-protein ligase RNF31, methyl 4-[(2-oxidanylidene-1,5,6,7-tetrahydrocyclopenta[b]pyridin-3-yl)carbonylamino]butanoate, ZINC ION, ...
Authors:Johansson, H., Tsai, Y.C.I., Fantom, K., Chung, C.W., Martino, L., House, D., Rittinger, K.
Deposit date:2018-07-05
Release date:2019-01-30
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
J. Am. Chem. Soc., 141, 2019
5NT1
  • Download 5nt1
  • View 5nt1
Molmil generated image of 5nt1
COMPLEX OF INFLUENZA A NS1 EFFECTOR DOMAIN WITH TRIM25 COILED COIL
Descriptor:E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1
Authors:Koliopoulos, M.G., Rittinger, K.
Deposit date:2017-04-27
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
5NT2
  • Download 5nt2
  • View 5nt2
Molmil generated image of 5nt2
COMPLEX OF INFLUENZA A NS1 WITH TRIM25 COILED COIL DOMAIN
Descriptor:Non-structural protein 1, E3 ubiquitin/ISG15 ligase TRIM25
Authors:Koliopoulos, M.G., Rittinger, K.
Deposit date:2017-04-27
Release date:2018-05-23
Method:X-RAY DIFFRACTION (4.259 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
6EYR
  • Download 6eyr
  • View 6eyr
Molmil generated image of 6eyr
CRYSTAL STRUCTURE OF THE SALMONELLA EFFECTOR SSEK3
Descriptor:Type III secretion system effector protein
Authors:Esposito, D., Rittinger, K.
Deposit date:2017-11-13
Release date:2018-02-28
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the glycosyltransferase activity of theSalmonellaeffector SseK3.
J. Biol. Chem., 293, 2018
6EYT
  • Download 6eyt
  • View 6eyt
Molmil generated image of 6eyt
CRYSTAL STRUCTURE OF THE SALMONELLA EFFECTOR SSEK3 IN COMPLEX WITH UDP-GLCNAC AND MANGANESE
Descriptor:Type III secretion system effector protein, IODIDE ION, MANGANESE (II) ION, ...
Authors:Esposito, D., Rittinger, K.
Deposit date:2017-11-13
Release date:2018-02-28
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural basis for the glycosyltransferase activity of theSalmonellaeffector SseK3.
J. Biol. Chem., 293, 2018
1OW3
  • Download 1ow3
  • View 1ow3
Molmil generated image of 1ow3
CRYSTAL STRUCTURE OF RHOA.GDP.MGF3-IN COMPLEX WITH RHOGAP
Descriptor:Rho-GTPase-activating protein 1, Transforming protein RhoA, MAGNESIUM ION, ...
Authors:Graham, D.L., Lowe, P.N., Grime, G.W., Marsh, M., Rittinger, K., Smerdon, S.J., Gamblin, S.J., Eccleston, J.F.
Deposit date:2003-03-28
Release date:2003-05-06
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:MgF(3)(-) as a Transition State Analog of Phosphoryl Transfer
Chem.Biol., 9, 2002
2AK5
  • Download 2ak5
  • View 2ak5
Molmil generated image of 2ak5
BETA PIX-SH3 COMPLEXED WITH A CBL-B PEPTIDE
Descriptor:Rho guanine nucleotide exchange factor 7, 8-residue peptide from a signal transduction protein CBL-B
Authors:Jozic, D., Cardenes, N., Deribe, Y.L., Moncalian, G., Hoeller, D., Groemping, Y., Dikic, I., Rittinger, K., Bravo, J.
Deposit date:2005-08-03
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cbl promotes clustering of endocytic adaptor proteins.
Nat.Struct.Mol.Biol., 12, 2005
2VRW
  • Download 2vrw
  • View 2vrw
Molmil generated image of 2vrw
CRITICAL STRUCTURAL ROLE FOR THE PH AND C1 DOMAINS OF THE VAV1 EXCHANGE FACTOR
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, PROTO-ONCOGENE VAV, ZINC ION
Authors:Rapley, J., Tybulewicz, V., Rittinger, K.
Deposit date:2008-04-16
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.
Embo Rep., 9, 2008
2W6A
  • Download 2w6a
  • View 2w6a
Molmil generated image of 2w6a
X-RAY STRUCTURE OF THE DIMERIC GIT1 COILED-COIL DOMAIN
Descriptor:ARF GTPASE-ACTIVATING PROTEIN GIT1
Authors:Schlenker, O., Rittinger, K.
Deposit date:2008-12-17
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structures of Dimeric Git1 and Trimeric Beta-Pix and Implications for Git-Pix Complex Assembly.
J.Mol.Biol., 386, 2009
2W6B
  • Download 2w6b
  • View 2w6b
Molmil generated image of 2w6b
CRYSTAL STRUCTURE OF THE TRIMERIC BETA-PIX COILED-COIL DOMAIN
Descriptor:RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7
Authors:Schlenker, O., Rittinger, K.
Deposit date:2008-12-17
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Dimeric Git1 and Trimeric Beta-Pix and Implications for Git-Pix Complex Assembly.
J.Mol.Biol., 386, 2009
4EMO
  • Download 4emo
  • View 4emo
Molmil generated image of 4emo
CRYSTAL STRUCTURE OF THE PH DOMAIN OF SHARPIN
Descriptor:Sharpin
Authors:Stieglitz, B., Haire, L.F., Dikic, I., Rittinger, K.
Deposit date:2012-04-12
Release date:2012-05-02
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold.
J.Biol.Chem., 287, 2012
4LJO
  • Download 4ljo
  • View 4ljo
Molmil generated image of 4ljo
STRUCTURE OF AN ACTIVE LIGASE (HOIP)/UBIQUITIN TRANSFER COMPLEX
Descriptor:E3 ubiquitin-protein ligase RNF31, Polyubiquitin-C, ZINC ION, ...
Authors:Rana, R.R., Stieglitz, B., Koliopoulos, M.G., Morris-Davies, A.C., Christodoulou, E., Howell, S., Brown, N.R., Rittinger, K.
Deposit date:2013-07-05
Release date:2013-10-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.564 Å)
Cite:Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature, 503, 2013
4LJP
  • Download 4ljp
  • View 4ljp
Molmil generated image of 4ljp
STRUCTURE OF AN ACTIVE LIGASE (HOIP-H889A)/UBIQUITIN TRANSFER COMPLEX
Descriptor:E3 ubiquitin-protein ligase RNF31, Polyubiquitin-C, ZINC ION
Authors:Rana, R.R., Stieglitz, B., Koliopoulos, M.G., Morris-Davies, A.C., Christodoulou, E., Howell, S., Brown, N.R., Rittinger, K.
Deposit date:2013-07-05
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature, 503, 2013
4LJQ
  • Download 4ljq
  • View 4ljq
Molmil generated image of 4ljq
CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF E3 LIGASE HOIP
Descriptor:E3 ubiquitin-protein ligase RNF31, ZINC ION
Authors:Stieglitz, B., Rana, R.R., Koliopoulos, M.G., Morris-Davies, A.C., Christodoulou, E., Howell, S., Brown, N.R., Rittinger, K.
Deposit date:2013-07-05
Release date:2013-10-16
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature, 503, 2013
6GGO
  • Download 6ggo
  • View 6ggo
Molmil generated image of 6ggo
CRYSTAL STRUCTURE OF SALMONELLA ZINC METALLOPROTEASE EFFECTOR GTGA
Descriptor:Bacteriophage virulence determinant, ZINC ION, CHLORIDE ION
Authors:Jennings, E., Esposito, D., Rittinger, K., Thurston, T.
Deposit date:2018-05-03
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-kappa B.
J. Biol. Chem., 293, 2018
6GGR
  • Download 6ggr
  • View 6ggr
Molmil generated image of 6ggr
CRYSTAL STRUCTURE OF SALMONELLA ZINC METALLOPROTEASE EFFECTOR GTGA IN COMPLEX WITH P65
Descriptor:Transcription factor p65, Bacteriophage virulence determinant, CHLORIDE ION
Authors:Jennings, E., Esposito, D., Rittinger, K., Thurston, T.
Deposit date:2018-05-03
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-kappa B.
J. Biol. Chem., 293, 2018
<12>